Bacterial toxic-shock syndrome
Synonyms: Bacterial TSS
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Bacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins, usually caused by an infection with <i>Staphylococcus aureus</i> in staphylococcal TSS or <i>Streptococcus pyogenes</i> in streptococcal TSS.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Bacterial toxic-shock syndrome | Bacterial TSS |
| fr | Syndrome du choc toxique bactérien | SCT bactérien |
| de | Toxisches Schock-Syndrom, bakterielles | Bakterielles TSS |
| es | Síndrome de shock tóxico bacteriano | SST bacteriano · Síndrome de choque tóxico bacteriano · TSS bacteriano |
| it | Sindrome dello shock tossico batterico | TSS batterica |
| nl | Bacteriële toxischeshocksyndroom | Bacteriële TSS |
| pt | Síndrome do choque tóxico bacteriano | |
| pl | Zespół bakteryjnego wstrząsu toksycznego | Bakteryjny TSS |
| cs | Syndrom toxického šoku | TSS |
| uk | Синдром бактеріального токсичного шоку | Бактеріальний TSS |
| zh | 细菌中毒性休克综合征 | 细菌中毒性休克综合征 |
| tr | Bakteriyel toksik şok sendromu | Bakteriyel TSS |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A48.3 | E | specific | validated |
| ICD-11 | 1C45 | E | specific | validated |
| MONDO | 0001881 | E | validated | |
| UMLS | C0600327 | E | validated | |
| GARD | 9560 | E | validated | |
| MedDRA | 10044248 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163582Rare bacterial infectious disease
rare infectious diseases
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 3 / 100 000 | Worldwide | Value and class | Not yet validated | 15264985[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
60 annotations · validated 2020-04-16| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002615 | Hypotension | |
| HP:0032169 | Severe infection | |
| HP:0031273 | Shock | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0011799 | Abnormality of facial soft tissue | |
| HP:0001289 | Confusion | |
| HP:0100537 | Fasciitis | |
| HP:0001945 | Fever | |
| HP:0002151 | Increased circulating lactate concentration | |
| HP:0001942 | Metabolic acidosis | |
| HP:0003326 | Myalgia | |
| HP:0012531 | Pain | |
| HP:0001581 | Recurrent skin infections | |
| HP:0002098 | Respiratory distress | |
| HP:0001649 | Tachycardia | |
| Occasional (29-5%) | ||
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0002814 | Abnormality of the lower limb | |
| HP:0002817 | Abnormality of the upper limb | |
| HP:0025615 | Abscess | |
| HP:0032675 | Acute cutaneous wound | |
| HP:0001369 | Arthritis | |
| HP:0031864 | Bacteremia | |
| HP:0030005 | Capillary leak | |
| HP:0100658 | Cellulitis | |
| HP:0025143 | Chills | |
| HP:0002014 | Diarrhea | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0031364 | Ecchymosis | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0003259 | Elevated circulating creatinine concentration | |
| HP:0000099 | Glomerulonephritis | |
| HP:0012115 | Hepatitis | |
| HP:0003073 | Hypoalbuminemia | |
| HP:0002901 | Hypocalcemia | |
| HP:0032238 | Increased circulating metamyelocyte count | |
| HP:0032237 | Increased circulating myelocyte count | |
| HP:0002383 | Infectious encephalitis | |
| HP:0011355 | Localized skin lesion | |
| HP:0001287 | Meningitis | |
| HP:0012819 | Myocarditis | |
| HP:0100614 | Myositis | |
| HP:0002018 | Nausea | |
| HP:0002754 | Osteomyelitis | |
| HP:0002586 | Peritonitis | |
| HP:0025439 | Pharyngitis | |
| HP:0002090 | Pneumonia | |
| HP:0000083 | Renal insufficiency | |
| HP:0011947 | Respiratory tract infection | |
| HP:0040189 | Scaling skin | |
| HP:0100806 | Sepsis | |
| HP:0003095 | Septic arthritis | |
| HP:0032170 | Severe varicella zoster infection | |
| HP:0031691 | Severe viral infection | |
| HP:0000246 | Sinusitis | |
| HP:0000988 | Skin rash | |
| HP:0002789 | Tachypnea | |
| HP:0001873 | Thrombocytopenia | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0000969 | Edema | |
| HP:0000010 | Recurrent urinary tract infections | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 23830657[PMID]_26866227[PMID]_25444488[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/36234
- This record as JSON: /data/d/36234.json