{"orpha":36234,"name":"Bacterial toxic-shock syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Bacterial TSS"],"definition":"Bacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins, usually caused by an infection with <i>Staphylococcus aureus</i> in staphylococcal TSS or <i>Streptococcus pyogenes</i> in streptococcal TSS.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-36234/","orphanet_url":"https://www.orpha.net/en/disease/detail/36234","names":{"fr":{"name":"Syndrome du choc toxique bactérien","synonyms":["SCT bactérien"],"definition":"Maladie aiguë mettant en jeu le pronostic vital, caractérisée par l'apparition soudaine d'une forte fièvre accompagnée de nausées, de myalgies, de vomissements et d'une défaillance multiviscérale, pouvant conduire à un état de choc et au décès. Le SCT est médiée par la production de toxines superantigéniques en réponse à une infection bactérienne à <i>Staphylococcus aureus</i> dans le cas du SCT staphylococcique ou à <i>Streptococcus pyogenes</i> dans le cas du SCT streptococcique."},"de":{"name":"Toxisches Schock-Syndrom, bakterielles","synonyms":["Bakterielles TSS"],"definition":"Das bakterielle toxische Schocksyndrom (TSS) ist eine potentiell letal verlaufende akute Erkrankung, die durch einen plötzlichen Beginn mit hohem Fieber mit Übelkeit, Muskelschmerzen, Erbrechen und Multiorganbeteiligung charakterisiert ist und zum Schock und auch zum Tod führen kann. TSS wird durch Superantigen-Toxine vermittelt, die üblicherweise durch eine Infektion mit <i>Staphylococcus aureus</i> bei der Staphloxkokken-TSS oder durch <i>Streptococcus pyogenes</i> bei der Streptokokken-TSS verursacht wird."},"es":{"name":"Síndrome de shock tóxico bacteriano","synonyms":["SST bacteriano","Síndrome de choque tóxico bacteriano","TSS bacteriano"],"definition":"El síndrome de shock tóxico bacteriano (SST) es una enfermedad aguda potencialmente mortal, que se caracteriza por la aparición repentina de fiebre alta acompañada de náuseas, mialgia, vómitos y afectación orgánica multisistémica, que pueden conducir a un shock y fallecimiento. El SST está mediado por toxinas superantigénicas, generalmente causado por una infección producida por <i>Staphylococcus aureus</i> en el caso del SST estafilocócico, o por <i>Streptococcus pyogenes</i> en el caso del SST estreptocócico."},"it":{"name":"Sindrome dello shock tossico batterico","synonyms":["TSS batterica"],"definition":"La sindrome dello shock tossico batterico (TSS) è una malattia acuta. potenzialmente letale, caratterizzata dall'improvvisa insorgenza di febbre elevata, associata a nausea, mialgia, vomito e interessamento multiorgano, che può potenzialmente causare lo shock e il decesso. La TSS è mediata da tossine superantigeniche e di solito è dovuta a un'infezione da Staphylococcus aureus (in caso di TSS staficoloccica) oppure da Streptococcus pyogenes (in caso di TSS streptococcica)."},"nl":{"name":"Bacteriële toxischeshocksyndroom","synonyms":["Bacteriële TSS"],"definition":"Bacteriële toxischeshocksyndroom (TSS) is een potentieel fatale, acute aandoening die gekenmerkt wordt door een plotse aanvang van hoge koorts samen met misselijkheid, myalgie, braken en multisystemische orgaanbetrokkenheid, wat potentieel leidt tot shock en overlijden. TSS wordt gemedieerd door superantigene toxines, meestal veroorzaakt door een infectie met <i>Staphylococcus aureus</i> bij staphylococcale TSS of <i>Streptococcus pyogenes</i> bij streptococcale TSS."},"pt":{"name":"Síndrome do choque tóxico bacteriano"},"pl":{"name":"Zespół bakteryjnego wstrząsu toksycznego","synonyms":["Bakteryjny TSS"]},"cs":{"name":"Syndrom toxického šoku","synonyms":["TSS"]},"uk":{"name":"Синдром бактеріального токсичного шоку","synonyms":["Бактеріальний TSS"],"definition":"Bacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins, usually caused by an infection with <i>Staphylococcus aureus</i> in staphylococcal TSS (see this term) or <i>Streptococcus pyogenes</i> in streptococcal TSS (see this term)."},"zh":{"name":"细菌中毒性休克综合征","synonyms":["细菌中毒性休克综合征"]},"tr":{"name":"Bakteriyel toksik şok sendromu","synonyms":["Bakteriyel TSS"]}},"xrefs":[{"source":"ICD-10","code":"A48.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C45","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"114886962"},{"source":"MONDO","code":"0001881","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0600327","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9560","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044248","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[{"orpha":99919,"name":"Staphylococcal toxic-shock syndrome","type":"Etiological subtype"},{"orpha":99918,"name":"Streptococcal toxic-shock syndrome","type":"Etiological subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":3.0,"area":"Worldwide","status":"Not yet validated","source":"15264985[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-16","source":"23830657[PMID]_26866227[PMID]_25444488[PMID]","terms":[{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032169","label":"Severe infection","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011799","label":"Abnormality of facial soft tissue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100537","label":"Fasciitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002151","label":"Increased circulating lactate concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001942","label":"Metabolic acidosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012531","label":"Pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001581","label":"Recurrent skin infections","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008066","label":"Abnormal blistering of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002814","label":"Abnormality of the lower limb","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002817","label":"Abnormality of the upper limb","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025615","label":"Abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032675","label":"Acute cutaneous wound","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031864","label":"Bacteremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100658","label":"Cellulitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031364","label":"Ecchymosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000099","label":"Glomerulonephritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003073","label":"Hypoalbuminemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002901","label":"Hypocalcemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032238","label":"Increased circulating metamyelocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032237","label":"Increased circulating myelocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011355","label":"Localized skin lesion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100614","label":"Myositis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011947","label":"Respiratory tract infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040189","label":"Scaling skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003095","label":"Septic arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032170","label":"Severe varicella zoster infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031691","label":"Severe viral infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000246","label":"Sinusitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000010","label":"Recurrent urinary tract infections","frequency":"Very rare (<4-1%)","criteria":null}]}}