raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:99919

Staphylococcal toxic-shock syndrome

Synonyms: Staphylococcal TSS

Type
Etiological subtype
Group
Subtype of disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a <i>Staphylococcus aureus</i> bacterial infection.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enStaphylococcal toxic-shock syndromeStaphylococcal TSS
frSyndrome du choc toxique staphylococciqueSCT staphylococcique
deToxisches Schock-Syndrom, Staphylokokken-induziertesStaphylokokken-TSS
esSíndrome del shock tóxico estafilocócicoSíndrome de shock tóxico por estafilococos · TSS por estafilococos
itSindrome dello shock tossico da stafilococcoTSS da stafilococco
nlStafylokokkale toxische shock-syndroomStafylokokkale TSS
ptSíndrome de choque tóxico estafilocócico
plGronkowcowy zespół wstrząsu toksycznegoGronkowcowy TSS
csStafylokokový syndrom toxického šokuStafylokokový TSS
ukСтафілококовий синдром токсичного шокуСтафілококовий TSS
zh葡萄球菌中毒性休克综合征葡萄球菌性TSS
trStafilokokal toksik şok sendromu= en

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A48.3NTBTattributedvalidated
ICD-111C45.1Especificvalidated
MONDO0020545Evalidated
UMLSC3714602Evalidated
MedDRA10044250Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (2):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

2 records
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyNot yet validatedORPHANET
Annual incidence1-9 / 1 000 0000.58 / 100 000United StatesValue and classValidated21860665[PMID]_24188357[PMID]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

7

Sources for this card