Intestinal botulism
Synonyms: Intestinal colonization botulism · Intestinal toxemia botulism · Intestinal toxin-mediated botulism
- Type
- Clinical subtype
- Group
- Subtype of disorder
- Age of onset
- All ages
- Status
- active
A rare form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), and is due to intestinal colonization by <i>Clostridium botulinum</i> leading to toxin-mediated infection with toxemia. The disease affects infants (infant botulism) and very rarely adults (adult intestinal botulism).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Intestinal botulism | Intestinal colonization botulism · Intestinal toxemia botulism · Intestinal toxin-mediated botulism |
| fr | Botulisme intestinal | Botulisme par colonisation intestinale · Botulisme par toxi-infection intestinale · Toxi-infection botulique intestinale |
| de | Botulismus, intestinaler | Botulismus, intestinaler, toxämischer |
| es | Botulismo intestinal | Botulismo con toxemia intestinal · Botulismo intestinal por toxinas · Botulismo por colonización intestinal |
| it | Botulismo intestinale | Botulismo da colonizzazione intestinale · Botulismo da tossiemia intestinale · Botulismo intestinale tossino-mediato |
| nl | Intestinaal botulisme | Botulisme geassocieerd met intestinale kolonisatie · Intestinaal toxemisch botulisme · Intestinaal toxine-gemedieerd botulisme |
| pt | Toxemia por botulismo intestinal | |
| pl | Botulizm jelitowy | = en |
| cs | Střevní botulismus | Střevní kolonizující botulismus · Střevní toxemický botulismus · Střevní botulismus způsobený toxinem |
| uk | Кишковий ботулізм | Кишковий колонізаційний ботулізм · Кишкова токсикоінфекція ботулізм · Ботулізм, спричинений кишковим токсином |
| zh | 肠肉毒中毒 | 肠毒素介导肉毒中毒 |
| tr | Bağırsak botulizmi | Bağırsak toksemisi botulizmi · Bağırsak kolonizasyonu botulizmi · Bağırsak toksin aracılı botulizm |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A05.1 | NTBT | attributed | validated |
| ICD-11 | 1A11.1 | BTNT | specific | validated |
| MONDO | 0015805 | E | validated | |
| UMLS | C1443901 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:230800Toxin-mediated infectious botulism
rare neurological diseases; rare ophthalmic disorders; rare infectious diseases
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
13 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0006824 | Cranial nerve paralysis | |
| HP:0000651 | Diplopia | |
| HP:0001260 | Dysarthria | |
| HP:0002015 | Dysphagia | |
| HP:0001252 | Hypotonia | |
| HP:0011499 | Mydriasis | |
| HP:0000508 | Ptosis | |
| Frequent (79-30%) | ||
| HP:0002014 | Diarrhea | |
| HP:0002017 | Nausea and vomiting | |
| HP:0000217 | Xerostomia | |
| Occasional (29-5%) | ||
| HP:0001522 | Death in infancy | |
| HP:0002094 | Dyspnea | |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | |
Run the differential on the 7 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/178481
- This record as JSON: /data/d/178481.json