Infant botulism
Synonyms: Infant intestinal botulism · Infant intestinal toxemia botulism · Infant intestinal toxin-mediated botulism · Infantile botulism
- Type
- Clinical subtype
- Group
- Subtype of disorder
- Age of onset
- Infancy, Neonatal
- Status
- active
A rare form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis caused by botulinum neurotoxins (BoNTs). It is due to intestinal colonization by <i>Clostridium botulinum</i> leading to toxin-mediated infection with toxemia.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Infant botulism | Infant intestinal botulism · Infant intestinal toxemia botulism · Infant intestinal toxin-mediated botulism · Infantile botulism |
| fr | Botulisme infantile | Botulisme du nourrisson · Botulisme intestinal de l'enfant · Botulisme néonatal · Botulisme par colonisation intestinale de l'enfant · Botulisme par toxi-infection intestinale de l'enfant |
| de | Säuglingsbotulismus | |
| es | Botulismo infantil | Botulismo con toxemia intestinal infantil · Botulismo intestinal infantil · Botulismo intestinal por toxinas infantil |
| it | Botulismo infantile | Botulismo infantile da tossiemia intestinale · Botulismo intestinale neonatale · Botulismo intestinale tossino-mediato infantile · Botulismo neonatale |
| nl | Botulisme bij zuigeling | Infantiel botulisme · Intestinaal botulisme bij zuigeling · Intestinaal toxemisch botulisme bij zuigeling · Intestinaal toxine-gemedieerd botulisme bij zuigeling |
| pt | Botulismo infantil | |
| pl | Botulizm niemowlęcy | Dziecięcy botulizm jelitowy |
| cs | Kojenecký botulismus | Kojenecký střevní botulismus · Kojenecký střevní toxemický botulismus · Kojenecký střevní botulismus způsobený toxinem |
| uk | Дитячий ботулізм | Дитячий кишковий ботулізм · Дитяча кишкова токсикоінфекція ботулізм · Ботулізм немовлят, спричинений кишковим токсином · Дитячий ботулізм |
| zh | 婴儿型肉毒中毒 | 婴儿型肠毒素介导肉毒中毒 |
| tr | Bebek botulizmi | İnfantil botulizm · Bebek bağırsak botulizmi · Bebek bağırsak toksemisi botulizmi · Bebek bağırsak toksin-aracılı botulizm |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A05.1 | NTBT | attributed | validated |
| ICD-11 | 1A11.1 | NTBT | index | validated |
| MONDO | 0015804 | E | validated | |
| UMLS | C0238027 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:178481Intestinal botulism
rare neurological diseases; rare ophthalmic disorders; rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
5 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Prevalence at birth | 1-9 / 1 000 000 | 0.2 / 100 000 | Europe | Value and class | Validated | [EXPERT] |
| Annual incidence | 1-9 / 1 000 000 | 0.3 / 100 000 | Europe | Value and class | Validated | [EXPERT]_Center for Diseases Control and Prevention[OTHER]_ ORPHANET |
| Prevalence at birth | 1-9 / 100 000 | 2.1 / 100 000 | United States | Value and class | Validated | [EXPERT] |
| Prevalence at birth | 1-9 / 100 000 | 2.2 / 100 000 | Argentina | Value and class | Validated | [EXPERT] |
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
28 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0100022 | Abnormality of movement | |
| HP:0001620 | Abnormally high-pitched voice | |
| HP:0002039 | Anorexia | |
| HP:0100021 | Cerebral palsy | |
| HP:0002019 | Constipation | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0000651 | Diplopia | |
| HP:0002307 | Drooling | |
| HP:0001260 | Dysarthria | |
| HP:0002015 | Dysphagia | |
| HP:0001252 | Hypotonia | |
| HP:0001097 | Keratoconjunctivitis sicca | |
| HP:0000298 | Mask-like facies | |
| HP:0011499 | Mydriasis | |
| HP:0000508 | Ptosis | |
| HP:0002360 | Sleep abnormality | |
| HP:0000217 | Xerostomia | |
| Frequent (79-30%) | ||
| HP:0000600 | Abnormality of the pharynx | |
| HP:0001284 | Areflexia | |
| HP:0002607 | Bowel incontinence | |
| HP:0002094 | Dyspnea | |
| HP:0000822 | Hypertension | |
| HP:0002615 | Hypotension | |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0001695 | Cardiac arrest | |
| HP:0000389 | Chronic otitis media | |
| HP:0002902 | Hyponatremia | |
Run the differential on the 12 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/178478
- This record as JSON: /data/d/178478.json