ORPHA:1267
Botulism
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Botulism is a rare acquired neuromuscular junction disease, characterized by descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), including four clinical forms with different modes of acquisition.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Botulism | |
| fr | Botulisme | |
| de | Botulismus | |
| es | Botulismo | |
| it | Botulismo | |
| nl | Botulisme | |
| pt | Botulismo | |
| pl | Botulizm | |
| cs | Botulismus | Otrava botulotoxinem |
| uk | Ботулізм | |
| zh | 肉毒梭菌毒素中毒 | |
| tr | Botulizm |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A05.1 | E | specific | validated |
| ICD-11 | 1A11 | E | specific | validated |
| MONDO | 0005498 | E | validated | |
| MeSH | D001906 | E | validated | |
| UMLS | C0006057 | E | validated | |
| GARD | 943 | E | validated | |
| MedDRA | 10006041 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (4):
- ORPHA:98494Acquired neuromuscular junction disease
rare neurological diseases - ORPHA:163582Rare bacterial infectious disease
rare infectious diseases - ORPHA:519286Rare disorder of the pupil
rare ophthalmic disorders - ORPHA:519347Rare neuromuscular disorder with ocular motility/alignment anomaly
rare ophthalmic disorders
4
Genes
0 directOrphanet records no gene directly on this code.
5
Prevalence and incidence
25 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.022 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.255 / 100 000 | France | Value and class | Validated | OTHERitut de Veille Sanitaire 2016[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.35 / 100 000 | United States | Value and class | Validated | Center for Diseases Control and Prevention 2006[OTHER]_ORPHANET |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | [EXPERT] |
| Annual incidence | <1 / 1 000 000 | 0.026 / 100 000 | Austria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.006 / 100 000 | Belgium | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.028 / 100 000 | Bulgaria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.04 / 100 000 | Croatia | Value and class | Validated | European Centre for Disease prevention and Control 2013-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Czech Republic | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.024 / 100 000 | Denmark | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.012 / 100 000 | Finland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.006 / 100 000 | Germany | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.052 / 100 000 | Hungary | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.012 / 100 000 | Ireland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.052 / 100 000 | Italy | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.086 / 100 000 | Lithuania | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.002 / 100 000 | Netherlands | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.038 / 100 000 | Poland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.018 / 100 000 | Portugal | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.104 / 100 000 | Romania | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.004 / 100 000 | Spain | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.008 / 100 000 | United Kingdom | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.098 / 100 000 | Norway | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
18 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0100021 | Cerebral palsy | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0006597 | Diaphragmatic paralysis | |
| HP:0000651 | Diplopia | |
| HP:0001260 | Dysarthria | |
| HP:0002015 | Dysphagia | |
| HP:0012378 | Fatigue | |
| HP:0010547 | Muscle flaccidity | |
| HP:0011499 | Mydriasis | |
| HP:0000217 | Xerostomia | |
| Frequent (79-30%) | ||
| HP:0011675 | Arrhythmia | |
| HP:0002019 | Constipation | |
| HP:0002017 | Nausea and vomiting | |
| HP:0002093 | Respiratory insufficiency | |
| HP:0000016 | Urinary retention | |
| Occasional (29-5%) | ||
| HP:0009113 | Diaphragmatic weakness | |
| HP:0002014 | Diarrhea | |
Run the differential on the 11 obligate / very frequent terms
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1267
- This record as JSON: /data/d/1267.json