{"orpha":99919,"name":"Staphylococcal toxic-shock syndrome","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Staphylococcal TSS"],"definition":"Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a <i>Staphylococcus aureus</i> bacterial infection.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99919/","orphanet_url":"https://www.orpha.net/en/disease/detail/99919","names":{"fr":{"name":"Syndrome du choc toxique staphylococcique","synonyms":["SCT staphylococcique"],"definition":"Une maladie aigue, médiée par la production de toxines superantigéniques en réponse à une infection bactérienne par <i>Staphylococcus aureus</i>. Il se caractérise par une fièvre élevée, une éruption cutanée suivie par une desquamation cutanée, une hypotension, des vomissements, une diarrhée et conduit potentiellement à une insuffisance organique multisystémique."},"de":{"name":"Toxisches Schock-Syndrom, Staphylokokken-induziertes","synonyms":["Staphylokokken-TSS"],"definition":"Das durch Staphylokokken verursachte toxische Schocksyndrom (Staphylokokken-TSS) ist eine akute Erkrankung, die durch die Produktion von Superantigen-Toxinen ausgelöst wird und durch hohes Fieber, Hautausschlag gefolgt von Haut-Peeling, Hypotonie, Erbrechen, Durchfall gekennzeichnet ist. Diese Infektion kann potenziell zu einem Multiorganversagen führen."},"es":{"name":"Síndrome del shock tóxico estafilocócico","synonyms":["Síndrome de shock tóxico por estafilococos","TSS por estafilococos"],"definition":"El síndrome del shock tóxico estafilocócico (SST estafilocócico) es una enfermedad aguda mediada por la producción de toxinas superantigénicas, que se caracteriza por fiebre alta, erupciones cutáneas seguidas por descamación, hipotensión, vómitos y diarrea y posiblemente conducente a un fallo orgánico multisistémico causado por una infección bacteriana por <i>Staphylococcus aureus</i>."},"it":{"name":"Sindrome dello shock tossico da stafilococco","synonyms":["TSS da stafilococco"],"definition":"La sindrome da shock tossico da stafilococco (TSS stafilococcica) è una malattia acuta mediata dalla produzione di tossine superantigeniche, caratterizzata da febbre alta, eruzione cutanea seguita da desquamazione, ipotensione, vomito e diarrea, che può esitare nell'insufficienza multiorgano. È causata da un'infezione batterica da Staphylococcus aureus."},"nl":{"name":"Stafylokokkale toxische shock-syndroom","synonyms":["Stafylokokkale TSS"],"definition":"Staphylococcale toxischeshocksyndroom (staphylococcale TSS) is een acute ziekte die gemedieerd wordt door de productie van superantigene toxines, die gekenmerkt wordt door hoge koorts, huiduitslag gevolgd door afpellen van de huid, hypotensie, braken en diarree, die potentieel leidt tot multi-orgaanfalen, en die veroorzaakt wordt door een bacteriële infectie met <i>Staphylococcus aureus</i>."},"pt":{"name":"Síndrome de choque tóxico estafilocócico"},"pl":{"name":"Gronkowcowy zespół wstrząsu toksycznego","synonyms":["Gronkowcowy TSS"]},"cs":{"name":"Stafylokokový syndrom toxického šoku","synonyms":["Stafylokokový TSS"]},"uk":{"name":"Стафілококовий синдром токсичного шоку","synonyms":["Стафілококовий TSS"],"definition":"Staphylococcal toxic shock syndrome (staphylococcal TSS) is an acute disease mediated by the production of superantigenic toxins, characterized by high fever, skin rash followed by skin peeling, hypotension, vomiting, diarrhea and potentially leading to multisystem organ failure and caused by a <i>Staphylococcus aureus</i> bacterial infection."},"zh":{"name":"葡萄球菌中毒性休克综合征","synonyms":["葡萄球菌性TSS"],"definition":"葡萄球菌中毒性休克综合征是一种由超抗原毒素介导的急性疾病，以高热、皮疹、脱皮、低血压、呕吐、腹泻为特征，可能导致多系统器官衰竭，由金黄色葡萄球菌 细菌感染引起。"},"tr":{"name":"Stafilokokal toksik şok sendromu","synonyms":["Staphylococcal TSS"]}},"xrefs":[{"source":"ICD-10","code":"A48.3","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1C45.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"788554020"},{"source":"MONDO","code":"0020545","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C3714602","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044250","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":36234,"name":"Bacterial toxic-shock syndrome","classifications":[203]},{"orpha":300579,"name":"Staphylococcal toxemia","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.58,"area":"United States","status":"Validated","source":"21860665[PMID]_24188357[PMID]"}],"phenotypes":null}