raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:99829

Yellow fever

Synonyms: Bronze John · YF · Yellow Jack

Type
Disease
Group
Disorder
Age of onset
All ages
Status
active

Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enYellow feverBronze John · YF · Yellow Jack
frFièvre jaune
deGelbfieberYF
esFiebre amarillaFiebre de Barbados · Mal de Siam · YF
itFebbre gialla= en
nlGele koorts= en
ptFebre amarela
plŻółta febraBronze John · Yellow Jack · YF
csŽlutá zimnice= en
ukЖовта лихоманкаБронзовий Джон · Жовтий Джек · YF
zh黄热病= en
trSarıhummaYF · Bronz John · Sarı humma

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A95.0BTNTspecificvalidated
ICD-10A95.1BTNTspecificvalidated
ICD-10A95.9BTNTspecificvalidated
ICD-111D47Especificvalidated
MONDO0020502Evalidated
MeSHD015004Evalidated
UMLSC0043395Evalidated
GARD7914Evalidated
MedDRA10048240Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

2 records
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyNot yet validatedORPHANET
Annual incidence<1 / 1 000 000—EuropeClass onlyValidatedEuropean Centre for Disease prevention and Control 2017[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

47 annotations · validated 2021-09-03
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0031964Elevated circulating alanine aminotransferase concentration
HP:0001945Fever
HP:0003496Increased circulating IgM level
HP:0002018Nausea
HP:0020071Viremia
Frequent (79-30%)
HP:0002027Abdominal pain
HP:0001892Abnormal bleeding
HP:0001919Acute kidney injury
HP:0002829Arthralgia
HP:0001662Bradycardia
HP:0025143Chills
HP:0031956Elevated circulating aspartate aminotransferase concentration
HP:0003236Elevated circulating creatine kinase concentration
HP:0003259Elevated circulating creatinine concentration
HP:0030139Excessive bleeding after a venipuncture
HP:0002315Headache
HP:0002248Hematemesis
HP:0030783Increased circulating interleukin 6 concentration
HP:0001942Metabolic acidosis
HP:0003326Myalgia
HP:0006277Pancreatic hyperplasia
HP:0000083Renal insufficiency
HP:0002013Vomiting
Occasional (29-5%)
HP:0001735Acute pancreatitis
HP:0030005Capillary leak
HP:0001259Coma
HP:0032066Decreased serum bicarbonate concentration
HP:0002014Diarrhea
HP:0002904Hyperbilirubinemia
HP:0011900Hypofibrinogenemia
HP:0001974Increased total leukocyte count
HP:0000952Jaundice
HP:0003419Low back pain
HP:0011897Neutrophilia
HP:0008151Prolonged prothrombin time
HP:0003225Reduced coagulation factor V activity
HP:0001250Seizure
HP:0031273Shock
HP:0005115Supraventricular arrhythmia
HP:0001873Thrombocytopenia
Very rare (<4-1%)
HP:0100519Anuria
HP:0002516Increased intracranial pressure
HP:0011029Internal hemorrhage
HP:0031690Opportunistic infection
HP:0012664Reduced left ventricular ejection fraction
HP:0000988Skin rash
HP:0002133Status epilepticus

Run the differential on the 5 obligate / very frequent terms

Annotation source: 31340247[PMID]_31150098[PMID]_31104909[PMID]

7

Sources for this card