{"orpha":99829,"name":"Yellow fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Bronze John","YF","Yellow Jack"],"definition":"Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99829/","orphanet_url":"https://www.orpha.net/en/disease/detail/99829","names":{"fr":{"name":"Fièvre jaune","definition":"La fièvre jaune (FJ) est une maladie zoonotique causée par le virus FJ et caractérisée par une fièvre et des symptômes constitutionnels, pouvant évoluer en fièvre hémorragique virale sévère et fatale, avec un choc et une défaillance multiviscérale."},"de":{"name":"Gelbfieber","synonyms":["YF"],"definition":"Das Gelbfieber (YF), das vom YF-Virus verursacht wird, ist eine Zoonose mit Fieber und Allgemeinsymptomen, die potentiell in ein schweres und tödliches virales hämorrhagisches Fieber mit Schock und Multiorganversagen übergehen kann."},"es":{"name":"Fiebre amarilla","synonyms":["Fiebre de Barbados","Mal de Siam","YF"],"definition":"La fiebre amarilla (YF), causada por el virus YF, es una enfermedad zoonótica que se caracteriza por fiebre y síntomas constitucionales, con la posibilidad de progresar a una grave fiebre hemorrágica vírica y fatal con shock y fallo multiorgánico."},"it":{"name":"Febbre gialla","synonyms":["Bronze John","YF","Yellow Jack"],"definition":"La febbre gialla (YF), causata dal virus YF, è una malattia zoonotica caratterizzata da febbre, che può eventualmente evolvere in una febbre emorragica fatale con shock e insufficienza sistemica multi-organo."},"nl":{"name":"Gele koorts","synonyms":["Bronze John","YF","Yellow Jack"],"definition":"Gele koorts (YF), veroorzaakt door YF-virus, is een zoönotische ziekte die gekenmerkt wordt door koorts en constitutionele symptomen, met het potentieel om te evolueren tot ernstige en fatale virale hemorragische koorts met shock en multi-orgaanfalen."},"pt":{"name":"Febre amarela"},"pl":{"name":"Żółta febra","synonyms":["Bronze John","Yellow Jack","YF"]},"cs":{"name":"Žlutá zimnice","synonyms":["Bronze John","YF","Yellow Jack"]},"uk":{"name":"Жовта лихоманка","synonyms":["Бронзовий Джон","Жовтий Джек","YF"],"definition":"Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure."},"zh":{"name":"黄热病","synonyms":["Bronze John","YF","Yellow Jack"],"definition":"黄热病(YF)是由YF病毒引起的一种以发热和躯体症状为特征的人畜共患病，有可能发展为严重而致命的病毒性出血热，并伴有休克和多器官系统衰竭。"},"tr":{"name":"Sarıhumma","synonyms":["YF","Bronz John","Sarı humma"]}},"xrefs":[{"source":"ICD-10","code":"A95.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A95.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A95.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D47","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"383352795"},{"source":"MONDO","code":"0020502","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D015004","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0043395","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7914","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10048240","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-09-03","source":"31340247[PMID]_31150098[PMID]_31104909[PMID]","terms":[{"hpo":"HP:0031964","label":"Elevated circulating alanine aminotransferase concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031956","label":"Elevated circulating aspartate aminotransferase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030139","label":"Excessive bleeding after a venipuncture","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002248","label":"Hematemesis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030783","label":"Increased circulating interleukin 6 concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001942","label":"Metabolic acidosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006277","label":"Pancreatic hyperplasia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001735","label":"Acute pancreatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032066","label":"Decreased serum bicarbonate concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002904","label":"Hyperbilirubinemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011900","label":"Hypofibrinogenemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003419","label":"Low back pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011897","label":"Neutrophilia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008151","label":"Prolonged prothrombin time","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003225","label":"Reduced coagulation factor V activity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005115","label":"Supraventricular arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100519","label":"Anuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002516","label":"Increased intracranial pressure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011029","label":"Internal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031690","label":"Opportunistic infection","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012664","label":"Reduced left ventricular ejection fraction","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002133","label":"Status epilepticus","frequency":"Very rare (<4-1%)","criteria":null}]}}