raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:99828

Dengue fever

Synonyms: DF · Dengue virus infection

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enDengue feverDF · Dengue virus infection
frDengue
deDengue-FieberDF · DHF · Dengue hämorrhagisches Fieber · Dengue-Viruskrankheit
esFiebre del dengueDF · Infección por el virus del dengue
itFebbre dengueDF · Infezione da virus dengue
nlDenguekoortsDF · Dengue-virusinfectie
ptDengue
plGorączka DengaDF · Zakażnie wirusem Denga
csHorečka dengueDF · Infekce virem dengue
ukЛихоманка ДенгеВірусна інфекція денге · DF
zh登革热登革病毒感染
trDang hummasıDF · Dang virüsü enfeksiyonu

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
OMIM614371NTBTvalidated
ICD-10A97.0BTNTspecificvalidated
ICD-10A97.1BTNTspecificvalidated
ICD-10A97.2BTNTspecificvalidated
ICD-10A97.9BTNTspecificvalidated
ICD-111D20BTNTspecificvalidated
ICD-111D21BTNTspecificvalidated
ICD-111D22BTNTspecificvalidated
MONDO0005502Evalidated
MeSHD003715Evalidated
UMLSC0011311Evalidated
GARD6254Evalidated
MedDRA10012310Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

26 records
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyNot yet validatedORPHANET
Annual incidence>1 / 1000714 / 100 000WorldwideValue and classValidated22494122[PMID]
Annual incidence1-9 / 1 000 0000.5 / 100 000EuropeValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Point prevalence1-9 / 100 000—EuropeClass onlyValidatedEuropean Medicines Agency 2015[OTHER]
Annual incidence<1 / 1 000 000—GreeceClass onlyValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 0000.07 / 100 000SlovakiaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.22 / 100 000SloveniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.26 / 100 000SpainValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.7 / 100 000SwedenValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.72 / 100 000United KingdomValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.26 / 100 000NorwayValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 100 0001.14 / 100 000AustriaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.98 / 100 000BelgiumValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 0000.033 / 100 000CroatiaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.58 / 100 000EstoniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.98 / 100 000FinlandValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.36 / 100 000FranceValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.96 / 100 000GermanyValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.14 / 100 000HungaryValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.32 / 100 000IrelandValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.14 / 100 000ItalyValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.34 / 100 000LatviaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.15 / 100 000LithuaniaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence<1 / 1 000 0000.04 / 100 000LuxembourgValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.22 / 100 000MaltaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.1 / 100 000PortugalValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

22 annotations · validated 2016-06-01
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0001945Fever
HP:0002315Headache
Frequent (79-30%)
HP:0002027Abdominal pain
HP:0002829Arthralgia
HP:0000989Pruritus
HP:0000988Skin rash
Occasional (29-5%)
HP:0001541Ascites
HP:0000978Bruising susceptibility
HP:0006543Cardiorespiratory arrest
HP:0001342Cerebral hemorrhage
HP:0002014Diarrhea
HP:0000421Epistaxis
HP:0002239Gastrointestinal hemorrhage
HP:0000225Gingival bleeding
HP:0002240Hepatomegaly
HP:0003075Hypoproteinemia
HP:0002615Hypotension
HP:0001254Lethargy
HP:0001882Leukopenia
HP:0002017Nausea and vomiting
HP:0000967Petechiae
HP:0001873Thrombocytopenia

Run the differential on the 2 obligate / very frequent terms

7

Sources for this card