{"orpha":99828,"name":"Dengue fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["DF","Dengue virus infection"],"definition":"Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99828/","orphanet_url":"https://www.orpha.net/en/disease/detail/99828","names":{"fr":{"name":"Dengue","definition":"La dengue est une infection causée par un arbovirus caractérisé par une fièvre initiale non spécifique qui peut évoluer vers une forme plus sévère avec fuite capillaire et hémorragies (dengue hémorragique) et état de choc (dengue avec syndrome de choc)."},"de":{"name":"Dengue-Fieber","synonyms":["DF","DHF","Dengue hämorrhagisches Fieber","Dengue-Viruskrankheit"],"definition":"Das Dengue-Fieber (DF) ist eine vom Dengue-Virus verursachte arbovirale Erkrankung. Das DF beginnt unspezifisch mit Fieber und entwickelt sich manchmal zu schwereren Formen mit Kapillarlecks und Hämorrhagien (hämorrhagisches Dengue-Fieber, DHF) und Schock (Dengue-Schock-Syndrom, DSS)."},"es":{"name":"Fiebre del dengue","synonyms":["DF","Infección por el virus del dengue"],"definition":"La fiebre del dengue (DF), causada por el virus del dengue, es una enfermedad por arbovirus caracterizada por manifestaciones febriles iniciales inespecíficas que a veces pueden progresar a formas más graves que se presentan con fuga capilar y hemorragia (fiebre hemorrágica del dengue o DHF) y shock (síndrome de shock por dengue o DSS)."},"it":{"name":"Febbre dengue","synonyms":["DF","Infezione da virus dengue"],"definition":"La febbre dengue (DF), causata dal virus dengue, è un'arbovirosi caratterizzata all'inizio da febbre non specifica, che a volte evolve in forme più gravi con elevata permeabilità capillare ed emorragie (febbre emorragica dengue o DHF) e shock (sindrome da shock di dengue o DSS)."},"nl":{"name":"Denguekoorts","synonyms":["DF","Dengue-virusinfectie"],"definition":"Denguekoorts (DF), veroorzaakt door het denguevirus, is een arbovirale ziekte die gekenmerkt wordt door een initiële niet-specifieke febriele ziekte die soms kan evolueren tot ernstigere vormen die zich manifesteren met capillaire lekkage en bloeding (dengue hemorragische koorts, of DHF) en shock (dengue shocksyndroom, of DSS)."},"pt":{"name":"Dengue"},"pl":{"name":"Gorączka Denga","synonyms":["DF","Zakażnie wirusem Denga"]},"cs":{"name":"Horečka dengue","synonyms":["DF","Infekce virem dengue"]},"uk":{"name":"Лихоманка Денге","synonyms":["Вірусна інфекція денге","DF"],"definition":"Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS)."},"zh":{"name":"登革热","synonyms":["登革病毒感染"],"definition":"登革热(DF)由登革热病毒引起，是一种虫媒病毒病，最初是一种非特异性发热性疾病，有时会发展成更严重的形式，表现为毛细血管渗漏和出血(登革出血热，DHF)和休克(登革休克综合征，DSS)。"},"tr":{"name":"Dang humması","synonyms":["DF","Dang virüsü enfeksiyonu"]}},"xrefs":[{"source":"OMIM","code":"614371","qualifier":"NTBT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"A97.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A97.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A97.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A97.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D20","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"685093552"},{"source":"ICD-11","code":"1D21","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1302232870"},{"source":"ICD-11","code":"1D22","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"56575149"},{"source":"MONDO","code":"0005502","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D003715","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0011311","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6254","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10012310","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":714.0,"area":"Worldwide","status":"Validated","source":"22494122[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.5,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2015[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.07,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.7,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.72,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.26,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.14,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.98,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.033,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.58,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.98,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.36,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.96,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.34,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.15,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.04,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.22,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001541","label":"Ascites","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000978","label":"Bruising susceptibility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006543","label":"Cardiorespiratory arrest","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001342","label":"Cerebral hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002239","label":"Gastrointestinal hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000225","label":"Gingival bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003075","label":"Hypoproteinemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000967","label":"Petechiae","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null}]}}