ORPHA:99827
Crimean-Congo hemorrhagic fever
Synonyms: CCHF · Congo fever · Congo hemorrhagic fever · Crimean hemorrhagic fever
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Crimean-Congo hemorrhagic fever | CCHF · Congo fever · Congo hemorrhagic fever · Crimean hemorrhagic fever |
| fr | Fièvre hémorragique de Crimée-Congo | CCHF · Fièvre du Congo · Fièvre hémorragique de Crimée · Fièvre hémorragique du Congo |
| de | Krim-Kongo hämorrhagisches Fieber | CCHF · Kongo-Fieber · Krim-Kongo-Fieber |
| es | Fiebre hemorrágica de Crimea-Congo | CCHF · Fiebre del Congo · Fiebre hemorrágica de Crimea · Fiebre hemorrágica del Congo |
| it | Febbre emorragica di Crimea-Congo | CCHF · Febbre del Congo · Febbre emorragica del Congo · Febbre emorragica di Crimea |
| nl | Krim-Congo hemorragische koorts | CCHF · Congo hemorragische koorts · Congo-koorts · Krim hemorragische koorts |
| pt | Febre hemorrágica Crimea-Congo (CCHF) | |
| pl | Krymsko-Kongijska gorączka krwotoczna | CCHF · Gorączka Kongo · Gorączka krwotoczna Kongo · Krymska gorączka krwotoczna |
| cs | Krymsko-konžská hemoragická horečka | CCHF · Konžská horečka · Konžská hemoragická horečka · Krymská hemoragická horečka |
| uk | Кримсько-конголезька геморагічна лихоманка | CCHF · Лихоманка Конго · Геморагічна лихоманка Конго · Кримська геморагічна лихоманка |
| zh | 克里米亚-刚果出血热 | 克里米亚出血热 |
| tr | Kırım-Kongo kanamalı ateşi | KKKA · Kongo ateşi · Kongo kanamalı ateşi · Kırım kanamalı ateşi |
Definition in:
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Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A98.0 | E | specific | validated |
| ICD-11 | 1D49 | E | specific | validated |
| MONDO | 0020501 | E | validated | |
| MeSH | D006479 | E | validated | |
| UMLS | C0019099 | E | validated | |
| MedDRA | 10010685 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:341Viral hemorrhagic fever
rare infectious diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
| Point prevalence | <1 / 1 000 000 | — | Europe | Class only | Validated | European Medicines Agency 2018[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
78 annotations · validated 2021-09-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0030005 | Capillary leak | |
| HP:0001945 | Fever | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0001873 | Thrombocytopenia | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002039 | Anorexia | |
| HP:0032198 | Decreased prothrombin time | |
| HP:0002014 | Diarrhea | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0000421 | Epistaxis | |
| HP:0002315 | Headache | |
| HP:0002240 | Hepatomegaly | |
| HP:0003237 | Increased circulating IgG level | |
| HP:0025435 | Increased circulating lactate dehydrogenase concentration | |
| HP:0003326 | Myalgia | |
| HP:0002017 | Nausea and vomiting | |
| HP:0030833 | Neck pain | |
| HP:0200026 | Ocular pain | |
| HP:0003645 | Prolonged partial thromboplastin time | |
| HP:0025258 | Stiff neck | |
| HP:0020071 | Viremia | |
| Occasional (29-5%) | ||
| HP:0000707 | Abnormality of the nervous system | |
| HP:0000713 | Agitation | |
| HP:0001662 | Bradycardia | |
| HP:0025143 | Chills | |
| HP:0001259 | Coma | |
| HP:0001289 | Confusion | |
| HP:0000509 | Conjunctivitis | |
| HP:0031364 | Ecchymosis | |
| HP:0000712 | Emotional lability | |
| HP:0001262 | Excessive daytime somnolence | |
| HP:0002380 | Fasciculations | |
| HP:0000225 | Gingival bleeding | |
| HP:0002248 | Hematemesis | |
| HP:0000790 | Hematuria | |
| HP:0002105 | Hemoptysis | |
| HP:0001399 | Hepatic failure | |
| HP:0000975 | Hyperhidrosis | |
| HP:0000822 | Hypertension | |
| HP:0002615 | Hypotension | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0000952 | Jaundice | |
| HP:0001882 | Leukopenia | |
| HP:0002716 | Lymphadenopathy | |
| HP:0002249 | Melena | |
| HP:0000613 | Photophobia | |
| HP:0000979 | Purpura | |
| HP:0100247 | Recurrent singultus | |
| HP:0001744 | Splenomegaly | |
| HP:0001649 | Tachycardia | |
| HP:0002321 | Vertigo | |
| Very rare (<4-1%) | ||
| HP:0005162 | Abnormal left ventricular function | |
| HP:0001735 | Acute pancreatitis | |
| HP:0000846 | Adrenal insufficiency | |
| HP:0002829 | Arthralgia | |
| HP:0001541 | Ascites | |
| HP:0011710 | Bundle branch block | |
| HP:0001082 | Cholecystitis | |
| HP:0025420 | Diffuse alveolar hemorrhage | |
| HP:0000031 | Epididymitis | |
| HP:0012219 | Erythema nodosum | |
| HP:0011854 | Hemoperitoneum | |
| HP:0012151 | Hemothorax | |
| HP:0031218 | Inappropriate antidiuretic hormone secretion | |
| HP:0011029 | Internal hemorrhage | |
| HP:0012282 | Morbilliform rash | |
| HP:0012819 | Myocarditis | |
| HP:0011897 | Neutrophilia | |
| HP:0100796 | Orchitis | |
| HP:0001876 | Pancytopenia | |
| HP:0011850 | Parotitis | |
| HP:0001698 | Pericardial effusion | |
| HP:0000093 | Proteinuria | |
| HP:0002092 | Pulmonary arterial hypertension | |
| HP:0000573 | Retinal hemorrhage | |
| HP:0007420 | Spontaneous hematomas | |
| HP:0011896 | Subconjunctival hemorrhage | |
| HP:0100309 | Subdural hemorrhage | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 31607406[PMID]_32024724[PMID]_30666932[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/99827
- This record as JSON: /data/d/99827.json