{"orpha":99827,"name":"Crimean-Congo hemorrhagic fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["CCHF","Congo fever","Congo hemorrhagic fever","Crimean hemorrhagic fever"],"definition":"Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99827/","orphanet_url":"https://www.orpha.net/en/disease/detail/99827","names":{"fr":{"name":"Fièvre hémorragique de Crimée-Congo","synonyms":["CCHF","Fièvre du Congo","Fièvre hémorragique de Crimée","Fièvre hémorragique du Congo"],"definition":"La fièvre hémorragique de Crimée-Congo (CCHF) est une maladie zoonotique transmise par les tiques, causée par le virus CCHF et caractérisée initialement par une fièvre, des maux de tête et un malaise, suivis par des symptômes gastro-intestinaux et dans les cas sévères, par une hémorragie, un choc et une défaillance multiviscérale."},"de":{"name":"Krim-Kongo hämorrhagisches Fieber","synonyms":["CCHF","Kongo-Fieber","Krim-Kongo-Fieber"],"definition":"Das hämorrhagische Krim-Kongo-Fieber (CCHF) ist eine von Zecken übertragene Zoonose und wird durch das CCHF-Virus verursacht. Erste Symptome sind Fieber, Kopfschmerzen und Unwohlsein, gefolgt von gastrointestinalen Symptomen und, in schweren Fällen, Blutungen, Schock und Multiorganversagen."},"es":{"name":"Fiebre hemorrágica de Crimea-Congo","synonyms":["CCHF","Fiebre del Congo","Fiebre hemorrágica de Crimea","Fiebre hemorrágica del Congo"],"definition":"La fiebre hemorrágica de Crimea-Congo (CCHF) es una enfermedad zoonótica causada por el virus CCHF y transmitida por garrapatas que se caracteriza por fiebre inicial, dolor de cabeza y malestar, seguido de síntomas gastrointestinales y, en casos graves, sangrado, shock y fallo multiorgánico."},"it":{"name":"Febbre emorragica di Crimea-Congo","synonyms":["CCHF","Febbre del Congo","Febbre emorragica del Congo","Febbre emorragica di Crimea"],"definition":"La febbre emorragica della Crimea-Congo (CCHF) è una malattia zoonotica trasmessa dalle zecche, causata dal virus CCHF, caratterizzata da febbre, cefalea e malessere iniziali, seguiti da sintomi gastrointestinali e, nei casi gravi, da emorragie, shock e insufficienza sistemica multi-organo."},"nl":{"name":"Krim-Congo hemorragische koorts","synonyms":["CCHF","Congo hemorragische koorts","Congo-koorts","Krim hemorragische koorts"],"definition":"Krim-Congo hemorragische koorts (CCHF) is een door teken overgedragen zoönotische ziekte die veroorzaakt wordt door het CCHF-virus en die gekenmerkt wordt door initiële koorts, hoofpijn en malaise, gevolgd door gastro-intestinale symptomen en, in ernstige gevallen, bloeding, shock en multi-orgaanfalen."},"pt":{"name":"Febre hemorrágica Crimea-Congo (CCHF)"},"pl":{"name":"Krymsko-Kongijska gorączka krwotoczna","synonyms":["CCHF","Gorączka Kongo","Gorączka krwotoczna Kongo","Krymska gorączka krwotoczna"]},"cs":{"name":"Krymsko-konžská hemoragická horečka","synonyms":["CCHF","Konžská horečka","Konžská hemoragická horečka","Krymská hemoragická horečka"]},"uk":{"name":"Кримсько-конголезька геморагічна лихоманка","synonyms":["CCHF","Лихоманка Конго","Геморагічна лихоманка Конго","Кримська геморагічна лихоманка"],"definition":"Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by CCHF virus and characterized by initial fever, headache, and malaise followed by gastrointestinal symptoms and, in severe cases, bleeding, shock, and multi-organ system failure."},"zh":{"name":"克里米亚-刚果出血热","synonyms":["克里米亚出血热"],"definition":"克里米亚-刚果出血热(CCHF)是一种由CCHF病毒引起的蜱传播的人畜共患病，其特征是最初发热、头痛和身体不适，随后出现胃肠道症状，严重时会出现出血、休克和多器官系统衰竭。"},"tr":{"name":"Kırım-Kongo kanamalı ateşi","synonyms":["KKKA","Kongo ateşi","Kongo kanamalı ateşi","Kırım kanamalı ateşi"]}},"xrefs":[{"source":"ICD-10","code":"A98.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D49","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1562906700"},{"source":"MONDO","code":"0020501","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D006479","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0019099","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10010685","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-09-03","source":"31607406[PMID]_32024724[PMID]_30666932[PMID]","terms":[{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032198","label":"Decreased prothrombin time","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003237","label":"Increased circulating IgG level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030833","label":"Neck pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003645","label":"Prolonged partial thromboplastin time","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000713","label":"Agitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000509","label":"Conjunctivitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031364","label":"Ecchymosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000712","label":"Emotional lability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001262","label":"Excessive daytime somnolence","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002380","label":"Fasciculations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000225","label":"Gingival bleeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002248","label":"Hematemesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002249","label":"Melena","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000979","label":"Purpura","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100247","label":"Recurrent singultus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002321","label":"Vertigo","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005162","label":"Abnormal left ventricular function","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001735","label":"Acute pancreatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000846","label":"Adrenal insufficiency","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001541","label":"Ascites","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011710","label":"Bundle branch block","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001082","label":"Cholecystitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025420","label":"Diffuse alveolar hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000031","label":"Epididymitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011854","label":"Hemoperitoneum","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012151","label":"Hemothorax","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031218","label":"Inappropriate antidiuretic hormone secretion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011029","label":"Internal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012282","label":"Morbilliform rash","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012819","label":"Myocarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011897","label":"Neutrophilia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100796","label":"Orchitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001876","label":"Pancytopenia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011850","label":"Parotitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001698","label":"Pericardial effusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000093","label":"Proteinuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002092","label":"Pulmonary arterial hypertension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000573","label":"Retinal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007420","label":"Spontaneous hematomas","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011896","label":"Subconjunctival hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100309","label":"Subdural hemorrhage","frequency":"Very rare (<4-1%)","criteria":null}]}}