ORPHA:99826
Marburg hemorrhagic fever
Synonyms: Green monkey disease · MHF · Marburg virus disease
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Marburg hemorrhagic fever | Green monkey disease · MHF · Marburg virus disease |
| fr | Fièvre hémorragique de Marburg | Maladie du singe vert · Maladie à virus de Marbourg · Maladie à virus de Marburg · Fièvre hémorragique de Marbourg · MHF · Maladie de Marbourg · Maladie de Marburg |
| de | Marburg hämorrhagisches Fieber | Grüne Meerkatzen-Krankheit · MHF · Marburg-Viruskrankheit |
| es | Fiebre hemorrágica de Marburg | Enfermedad del mono verde · Enfermedad por el virus de Marburg · MHF |
| it | Febbre emorragica di Marburg | MHF · Malattia della scimmia verde · Malattia virale di Marburg |
| nl | Marburg hemorragische koorts | Groene aap-ziekte · MHF · Marburg-virusziekte |
| pt | Doença de Marburg | |
| pl | Gorączka krwotoczna Marburg | Choroba wirusowa Marburg · Choroba zielonych małp · MHF |
| cs | Marburská nemoc | = en |
| uk | Марбурзька геморагічна лихоманка | Хвороба зеленої мавпи · Марбурзька вірусна хвороба · MHF |
| zh | 马尔堡出血热 | 马尔堡病毒病 |
| tr | Marburg kanamalı ateşi | MHF · Yeşil maymun hastalığı · Marburg virüsü hastalığı |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A98.3 | E | specific | validated |
| ICD-11 | 1D60.1 | E | specific | validated |
| MONDO | 0020500 | E | validated | |
| MeSH | D008379 | E | validated | |
| UMLS | C0024788 | E | validated | |
| GARD | 9444 | E | validated | |
| MedDRA | 10026822 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:341Viral hemorrhagic fever
rare infectious diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 500 cases | Worldwide | Case(s) | Validated | [EXPERT] | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
74 annotations · validated 2021-08-30| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0030005 | Capillary leak | |
| HP:0010702 | Increased circulating immunoglobulin concentration | |
| HP:0001882 | Leukopenia | |
| HP:0001888 | Lymphopenia | |
| HP:0020071 | Viremia | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0001892 | Abnormal bleeding | |
| HP:0004332 | Abnormal lymphocyte morphology | |
| HP:0012137 | Abnormal number of granulocyte precursors | |
| HP:0002039 | Anorexia | |
| HP:0025143 | Chills | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0002014 | Diarrhea | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0003326 | Myalgia | |
| HP:0410257 | Neutrophilia in presence of infection | |
| HP:0032043 | Odynophagia | |
| HP:0001923 | Reticulocytosis | |
| HP:0032169 | Severe infection | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0003256 | Abnormality of the coagulation cascade | |
| HP:0000718 | Aggressive behavior | |
| HP:0002829 | Arthralgia | |
| HP:0003418 | Back pain | |
| HP:0025085 | Bloody diarrhea | |
| HP:0001662 | Bradycardia | |
| HP:0000978 | Bruising susceptibility | |
| HP:0001259 | Coma | |
| HP:0001289 | Confusion | |
| HP:0001944 | Dehydration | |
| HP:0002329 | Drowsiness | |
| HP:0012534 | Dysesthesia | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0003259 | Elevated circulating creatinine concentration | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0030139 | Excessive bleeding after a venipuncture | |
| HP:0410288 | Hyperamylasemia | |
| HP:0003073 | Hypoalbuminemia | |
| HP:0001943 | Hypoglycemia | |
| HP:0002900 | Hypokalemia | |
| HP:0002615 | Hypotension | |
| HP:0002045 | Hypothermia | |
| HP:0011029 | Internal hemorrhage | |
| HP:0003128 | Lactic acidosis | |
| HP:0001254 | Lethargy | |
| HP:0002716 | Lymphadenopathy | |
| HP:0040186 | Maculopapular exanthema | |
| HP:0002018 | Nausea | |
| HP:0031246 | Nonproductive cough | |
| HP:0011151 | Obtundation status | |
| HP:0000967 | Petechiae | |
| HP:0003645 | Prolonged partial thromboplastin time | |
| HP:0008151 | Prolonged prothrombin time | |
| HP:0000083 | Renal insufficiency | |
| HP:0001250 | Seizure | |
| HP:0031273 | Shock | |
| HP:0000988 | Skin rash | |
| HP:0011896 | Subconjunctival hemorrhage | |
| HP:0001649 | Tachycardia | |
| HP:0001873 | Thrombocytopenia | |
| Very rare (<4-1%) | ||
| HP:0004360 | Abnormality of acid-base homeostasis | |
| HP:0011024 | Abnormality of the gastrointestinal tract | |
| HP:0001369 | Arthritis | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0002480 | Hepatic encephalopathy | |
| HP:0001987 | Hyperammonemia | |
| HP:0011106 | Hypovolemia | |
| HP:0000952 | Jaundice | |
| HP:0100796 | Orchitis | |
| HP:0001733 | Pancreatitis | |
| HP:0001701 | Pericarditis | |
| HP:0000709 | Psychosis | |
| HP:0000554 | Uveitis | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 24816494[PMID]_31888676[PMID]_32758690[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/99826
- This record as JSON: /data/d/99826.json