{"orpha":99826,"name":"Marburg hemorrhagic fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Green monkey disease","MHF","Marburg virus disease"],"definition":"Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99826/","orphanet_url":"https://www.orpha.net/en/disease/detail/99826","names":{"fr":{"name":"Fièvre hémorragique de Marburg","synonyms":["Maladie du singe vert","Maladie à virus de Marbourg","Maladie à virus de Marburg","Fièvre hémorragique de Marbourg","MHF","Maladie de Marbourg","Maladie de Marburg"],"definition":"La fièvre hémorragique de Marburg (MHF), causée par le virus Marburg est une maladie hémorragique virale sévère caractérisée initialement par une fièvre et un malaise, suivis par des symptômes gastro-intestinaux, une hémorragie, un choc et une défaillance multiviscérale."},"de":{"name":"Marburg hämorrhagisches Fieber","synonyms":["Grüne Meerkatzen-Krankheit","MHF","Marburg-Viruskrankheit"],"definition":"Das Marburg-Fieber (MHF), verursacht durch das Marburg-Virus, ist eine schwere hämorrhagische Erkrankung. Sie beginnt mit Fieber und Unwohlsein, gefolgt von gastrointestinalen Symptomen, Blutungen, Schock und Multiorganversagen."},"es":{"name":"Fiebre hemorrágica de Marburg","synonyms":["Enfermedad del mono verde","Enfermedad por el virus de Marburg","MHF"],"definition":"La fiebre hemorrágica de Marburgo (MHF), causada por el virus de Marburgo, es una grave enfermedad hemorrágica vírica caracterizada por fiebre inicial y malestar seguidos de síntomas gastrointestinales, sangrado, shock y fallo multiorgánico."},"it":{"name":"Febbre emorragica di Marburg","synonyms":["MHF","Malattia della scimmia verde","Malattia virale di Marburg"],"definition":"La febbre emorragica di Marburg (MHF), causata dal virus di Marburg, è una grave malattia emorragica virale, caratterizzata da febbre e malessere iniziali, seguiti da sintomi intestinali, emorragie, shock e insufficienza sistemica multi-organo."},"nl":{"name":"Marburg hemorragische koorts","synonyms":["Groene aap-ziekte","MHF","Marburg-virusziekte"],"definition":"Marburg hemorragische koorts (MHF), veroorzaakt door het Marburgvirus, is een ernstige virale hemorragische ziekte die gekenmerkt wordt door initiële koorts en malaise, gevolgd door gastro-intestinale symptomen, bloeding, shock en multi-orgaanfalen."},"pt":{"name":"Doença de Marburg"},"pl":{"name":"Gorączka krwotoczna Marburg","synonyms":["Choroba wirusowa Marburg","Choroba zielonych małp","MHF"]},"cs":{"name":"Marburská nemoc","synonyms":["Green monkey disease","MHF","Marburg virus disease"]},"uk":{"name":"Марбурзька геморагічна лихоманка","synonyms":["Хвороба зеленої мавпи","Марбурзька вірусна хвороба","MHF"],"definition":"Marburg hemorrhagic fever (MHF), caused by Marburg virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure."},"zh":{"name":"马尔堡出血热","synonyms":["马尔堡病毒病"],"definition":"马尔堡出血热(MHF)是由马尔堡病毒(Marburg Virus)引起的一种以发热和不适为特征的严重病毒性出血热，随后出现胃肠道症状、出血、休克和多器官系统衰竭。"},"tr":{"name":"Marburg kanamalı ateşi","synonyms":["MHF","Yeşil maymun hastalığı","Marburg virüsü hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A98.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D60.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"696598707"},{"source":"MONDO","code":"0020500","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008379","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0024788","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9444","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10026822","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":500.0,"area":"Worldwide","status":"Validated","source":"[EXPERT]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-08-30","source":"24816494[PMID]_31888676[PMID]_32758690[PMID]","terms":[{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010702","label":"Increased circulating immunoglobulin concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001888","label":"Lymphopenia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004332","label":"Abnormal lymphocyte morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012137","label":"Abnormal number of granulocyte precursors","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002039","label":"Anorexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030953","label":"Conjunctival hyperemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0410257","label":"Neutrophilia in presence of infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032043","label":"Odynophagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001923","label":"Reticulocytosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032169","label":"Severe infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003256","label":"Abnormality of the coagulation cascade","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000718","label":"Aggressive behavior","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025085","label":"Bloody diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000978","label":"Bruising susceptibility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001944","label":"Dehydration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002329","label":"Drowsiness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012534","label":"Dysesthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030139","label":"Excessive bleeding after a venipuncture","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0410288","label":"Hyperamylasemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003073","label":"Hypoalbuminemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001943","label":"Hypoglycemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002900","label":"Hypokalemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002045","label":"Hypothermia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011029","label":"Internal hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003128","label":"Lactic acidosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031246","label":"Nonproductive cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011151","label":"Obtundation status","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000967","label":"Petechiae","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003645","label":"Prolonged partial thromboplastin time","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008151","label":"Prolonged prothrombin time","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011896","label":"Subconjunctival hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004360","label":"Abnormality of acid-base homeostasis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011024","label":"Abnormality of the gastrointestinal tract","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002480","label":"Hepatic encephalopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001987","label":"Hyperammonemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011106","label":"Hypovolemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000952","label":"Jaundice","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100796","label":"Orchitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001733","label":"Pancreatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000709","label":"Psychosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000554","label":"Uveitis","frequency":"Very rare (<4-1%)","criteria":null}]}}