ORPHA:662
Lymphedema with yellow nails
Synonyms: YNS · Yellow nail syndrome
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adult, Childhood, Neonatal
- Status
- active
A rare, syndromic nail anomaly disease characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Lymphedema with yellow nails | YNS · Yellow nail syndrome |
| fr | Lymphoedème avec ongles jaunes | Syndrome des ongles jaunes · YNS |
| de | Lymphödem mit gelben Nägeln | Gelbe-Nägel-Syndrom · YNS |
| es | Linfedema y uñas amarillas | Síndrome de las uñas amarillas |
| it | Linfedema con unghie gialle | Sindrome delle unghie gialle · Linfedema con unghie gialle · YNS |
| nl | Lymfoedeem met gele nagels | Gelenagelsyndroom · YNS |
| pt | Síndrome das unhas amarelas | |
| pl | Zespół żółtych paznokci | Obrzęk limfatyczny z żółtymi paznokciami · YNS |
| cs | Syndrom žlutých nehtů | Lymfedém se žlutými nehty · YNS |
| uk | Синдром жовтих нігтів | Лімфедема з жовтими нігтями · YNS |
| zh | 黄指甲综合征 | 淋巴水肿伴黄指甲 |
| tr | Sarı tırnak sendromu | YNS · Sarı tırnak ile seyreden lenfödem |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 153300 | E | validated | |
| ICD-10 | L60.5 | NTBT | attributed | validated |
| ICD-11 | EE11.1 | E | specific | validated |
| MONDO | 0007921 | E | validated | |
| MeSH | D056684 | E | validated | |
| UMLS | C0221348 | E | validated | |
| GARD | 184 | E | validated | |
| MedDRA | 10048244 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (3):
- ORPHA:264683Primary interstitial lung disease specific to childhood due to alveolar vascular disorder
rare respiratory diseases; rare transplant-related disorders - ORPHA:568044Primary lymphedema with systemic or visceral involvement
rare developmental anomalies during embryogenesis; rare genetic diseases; rare skin diseases; rare circulatory system diseases - ORPHA:79370Syndromic nail anomaly
rare skin diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 400 cases | Worldwide | Case(s) | Validated | 28241848[PMID] | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
24 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001231 | Abnormal fingernail morphology | |
| HP:0008388 | Abnormal toenail morphology | |
| HP:0002110 | Bronchiectasis | |
| HP:0100798 | Fingernail dysplasia | |
| HP:0003759 | Hypoplasia of lymphatic vessels | |
| HP:0001004 | Lymphedema | |
| HP:0100797 | Toenail dysplasia | |
| HP:0011367 | Yellow nails | |
| Frequent (79-30%) | ||
| HP:0012735 | Cough | |
| HP:0002094 | Dyspnea | |
| HP:0002102 | Pleuritis | |
| HP:0002205 | Recurrent respiratory infections | |
| HP:0012384 | Rhinitis | |
| HP:0000246 | Sinusitis | |
| Occasional (29-5%) | ||
| HP:0100574 | Biliary tract neoplasm | |
| HP:0011354 | Generalized abnormality of skin | |
| HP:0002721 | Immunodeficiency | |
| HP:0002664 | Neoplasm | |
| HP:0100526 | Neoplasm of the lung | |
| HP:0000112 | Nephropathy | |
| HP:0001806 | Onycholysis | |
| HP:0002092 | Pulmonary arterial hypertension | |
| HP:0009726 | Renal neoplasm | |
| HP:0100242 | Sarcoma | |
Run the differential on the 8 obligate / very frequent terms
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/662
- This record as JSON: /data/d/662.json