{"orpha":662,"name":"Lymphedema with yellow nails","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["YNS","Yellow nail syndrome"],"definition":"A rare, syndromic nail anomaly disease characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-662/","orphanet_url":"https://www.orpha.net/en/disease/detail/662","names":{"fr":{"name":"Lymphoedème avec ongles jaunes","synonyms":["Syndrome des ongles jaunes","YNS"],"definition":"Anomalie syndromique rare des ongles caractérisée par une triade variable d'ongles jaunes caractéristiques, de manifestations respiratoires chroniques et d'un lymphoedème primaire."},"de":{"name":"Lymphödem mit gelben Nägeln","synonyms":["Gelbe-Nägel-Syndrom","YNS"],"definition":"Eine seltene, syndromale Nagelanomalie, die durch die variable Trias von charakteristischen gelben Nägeln, chronischen Atemwegsmanifestationen und primären Lymphödemen gekennzeichnet ist."},"es":{"name":"Linfedema y uñas amarillas","synonyms":["Síndrome de las uñas amarillas"],"definition":"Es una rara enfermedad sindrómica de anomalías de las uñas caracterizada por la tríada variable de uñas amarillas características, manifestaciones respiratorias crónicas y linfedema primario."},"it":{"name":"Linfedema con unghie gialle","synonyms":["Sindrome delle unghie gialle","Linfedema con unghie gialle","YNS"],"definition":"Si tratta di un'anomalia sindromica rara delle unghie, caratterizzata dalla triade variabile unghie gialle, sintomi respiratori cronici e linfedema primitivo."},"nl":{"name":"Lymfoedeem met gele nagels","synonyms":["Gelenagelsyndroom","YNS"],"definition":"Een zeldzame, syndromale nagelanomalie die gekarakteriseerd wordt door de variabele triade van kenmerkende gele nagels, chronische respiratoire manifestaties, en primair lymfoedeem."},"pt":{"name":"Síndrome das unhas amarelas"},"pl":{"name":"Zespół żółtych paznokci","synonyms":["Obrzęk limfatyczny z żółtymi paznokciami","YNS"]},"cs":{"name":"Syndrom žlutých nehtů","synonyms":["Lymfedém se žlutými nehty","YNS"]},"uk":{"name":"Синдром жовтих нігтів","synonyms":["Лімфедема з жовтими нігтями","YNS"],"definition":"A rare, syndromic nail anomaly disease characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema."},"zh":{"name":"黄指甲综合征","synonyms":["淋巴水肿伴黄指甲"]},"tr":{"name":"Sarı tırnak sendromu","synonyms":["YNS","Sarı tırnak ile seyreden lenfödem"]}},"xrefs":[{"source":"OMIM","code":"153300","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"L60.5","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"EE11.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"47812081"},{"source":"MONDO","code":"0007921","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D056684","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0221348","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"184","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10048244","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":264683,"name":"Primary interstitial lung disease specific to childhood due to alveolar vascular disorder","classifications":[184,233]},{"orpha":568044,"name":"Primary lymphedema with systemic or visceral involvement","classifications":[147,156,187,198]},{"orpha":79370,"name":"Syndromic nail anomaly","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Childhood","Neonatal"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":400.0,"area":"Worldwide","status":"Validated","source":"28241848[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0001231","label":"Abnormal fingernail morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0008388","label":"Abnormal toenail morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002110","label":"Bronchiectasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100798","label":"Fingernail dysplasia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003759","label":"Hypoplasia of lymphatic vessels","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001004","label":"Lymphedema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100797","label":"Toenail dysplasia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011367","label":"Yellow nails","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002102","label":"Pleuritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002205","label":"Recurrent respiratory infections","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012384","label":"Rhinitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000246","label":"Sinusitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100574","label":"Biliary tract neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011354","label":"Generalized abnormality of skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100526","label":"Neoplasm of the lung","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000112","label":"Nephropathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001806","label":"Onycholysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002092","label":"Pulmonary arterial hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009726","label":"Renal neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100242","label":"Sarcoma","frequency":"Occasional (29-5%)","criteria":null}]}}