ORPHA:340
Hemorrhagic fever-renal syndrome
Synonyms: Hantavirosis · Hantavirus fever
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare rodent-borne, potentially severe, hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Hemorrhagic fever-renal syndrome | Hantavirosis · Hantavirus fever |
| fr | Syndrome de fièvre hémorragique-syndrome rénal | Fièvre à hantavirus · Hantavirose |
| de | Hämorrhagisches Fieber mit renalem Syndrom | HFRS · Hantavirose · Hantavirus-Fieber |
| es | Fiebre hemorrágica con síndrome renal | Fiebre por hantavirus · Hantaviriasis |
| it | Febbre emorragica con sindrome renale | Febbre da hantavirus · Hantavirosi |
| nl | Hemorragische koorts - renaal syndroom | Hantavirose · Koorts door hantavirus |
| pt | Febre hemorrágica com nefropatia | Febre por hantavírus · Hantavirose |
| pl | Gorączka krwotoczna - zespół nerkowy | Gorączka hantawirusowa · Zakażenie hantawirusowe |
| cs | Hemoragická horečka s ledvinovým syndromem | Hantaviróza · Hantavirová horečka |
| uk | Геморагічна лихоманка - нирковий синдром | Хантавіроз · Хантавірусна лихоманка |
| zh | 肾综合征出血热 | 汉坦病毒热 |
| tr | Hemorajik ateş-böbrek sendromu | Hantaviroz · Hantavirüs ateşi |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A98.5+ | E | specific | validated |
| ICD-10 | N08.0* | NTBT | index | validated |
| ICD-11 | 1D62.0 | E | specific | validated |
| MONDO | 0018081 | E | validated | |
| MeSH | C535630 | E | validated | |
| UMLS | C2930957 | E | validated | |
| MedDRA | 10023484 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:341Viral hemorrhagic fever
rare infectious diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
20 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.74 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 2.32 / 100 000 | Slovenia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 2.52 / 100 000 | Sweden | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.5 / 100 000 | Norway | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.92 / 100 000 | Austria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.78 / 100 000 | Belgium | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.06 / 100 000 | Bulgaria | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 2.2 / 100 000 | Croatia | Value and class | Validated | European Centre for Disease prevention and Control 2012-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.08 / 100 000 | Czech Republic | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.36 / 100 000 | Estonia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-5 / 10 000 | 29.16 / 100 000 | Finland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.18 / 100 000 | France | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.16 / 100 000 | Germany | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.08 / 100 000 | Hungary | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.3 / 100 000 | Latvia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 100 000 | 1.44 / 100 000 | Luxembourg | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Poland | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | <1 / 1 000 000 | 0.02 / 100 000 | Romania | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Annual incidence | 1-9 / 1 000 000 | 0.24 / 100 000 | Slovakia | Value and class | Validated | European Centre for Disease prevention and Control 2011-2015[OTHER] |
| Point prevalence | 1-5 / 10 000 | 37 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2004[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
60 annotations · validated 2021-08-27| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001919 | Acute kidney injury | |
| HP:0030005 | Capillary leak | |
| HP:0012213 | Decreased glomerular filtration rate | |
| HP:0011037 | Decreased urine output | |
| HP:0003259 | Elevated circulating creatinine concentration | |
| HP:0001945 | Fever | |
| HP:0100520 | Oliguria | |
| HP:0032169 | Severe infection | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0004729 | Acute tubulointerstitial nephritis | |
| HP:0003418 | Back pain | |
| HP:0000622 | Blurred vision | |
| HP:0025143 | Chills | |
| HP:0004325 | Decreased body weight | |
| HP:0001262 | Excessive daytime somnolence | |
| HP:0012378 | Fatigue | |
| HP:0000099 | Glomerulonephritis | |
| HP:0002315 | Headache | |
| HP:0002615 | Hypotension | |
| HP:0030783 | Increased circulating interleukin 6 concentration | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0001324 | Muscle weakness | |
| HP:0003326 | Myalgia | |
| HP:0002018 | Nausea | |
| HP:0001962 | Palpitations | |
| HP:0000967 | Petechiae | |
| HP:0000093 | Proteinuria | |
| HP:0001649 | Tachycardia | |
| HP:0001873 | Thrombocytopenia | |
| HP:0001970 | Tubulointerstitial nephritis | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0000713 | Agitation | |
| HP:0001903 | Anemia | |
| HP:0100519 | Anuria | |
| HP:0001289 | Confusion | |
| HP:0012735 | Cough | |
| HP:0002014 | Diarrhea | |
| HP:0002094 | Dyspnea | |
| HP:0031364 | Ecchymosis | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0002248 | Hematemesis | |
| HP:0000790 | Hematuria | |
| HP:0000975 | Hyperhidrosis | |
| HP:0002153 | Hyperkalemia | |
| HP:0002905 | Hyperphosphatemia | |
| HP:0100785 | Insomnia | |
| HP:0002202 | Pleural effusion | |
| HP:0002090 | Pneumonia | |
| HP:0100598 | Pulmonary edema | |
| HP:0002098 | Respiratory distress | |
| HP:0031273 | Shock | |
| HP:0011896 | Subconjunctival hemorrhage | |
| Very rare (<4-1%) | ||
| HP:0012622 | Chronic kidney disease | |
| HP:0001259 | Coma | |
| HP:0000421 | Epistaxis | |
| HP:0000822 | Hypertension | |
| HP:0011029 | Internal hemorrhage | |
| HP:0002170 | Intracranial hemorrhage | |
| HP:0002249 | Melena | |
| HP:0002878 | Respiratory failure | |
Run the differential on the 8 obligate / very frequent terms
Annotation source: 24750436[PMID]_32809495[PMID]_26870699[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/340
- This record as JSON: /data/d/340.json