{"orpha":340,"name":"Hemorrhagic fever-renal syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Hantavirosis","Hantavirus fever"],"definition":"A rare rodent-borne, potentially severe, hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-340/","orphanet_url":"https://www.orpha.net/en/disease/detail/340","names":{"fr":{"name":"Syndrome de fièvre hémorragique-syndrome rénal","synonyms":["Fièvre à hantavirus","Hantavirose"],"definition":"Maladie hémorragique potentiellement sévère transmise par les rongeurs, causée par des hantavirus de l'Ancien Monde et caractérisée par une forte fièvre, des malaises, des céphalées, une myalgie, une arthralgie, des douleurs lombaires et abdominales, une oligurie/insuffisance rénale et des manifestations hémorragiques systémiques."},"de":{"name":"Hämorrhagisches Fieber mit renalem Syndrom","synonyms":["HFRS","Hantavirose","Hantavirus-Fieber"],"definition":"Eine seltene, von Nagetieren übertragene, potenziell schwere hämorrhagische Erkrankung, die durch Hantaviren der Alten Welt verursacht wird und durch hohes Fieber, Unwohlsein, Kopfschmerzen, Myalgie, Arthralgie, Rückenschmerzen, Bauchschmerzen, Oligurie/Nierenversagen und systemische hämorrhagische Manifestationen gekennzeichnet ist."},"es":{"name":"Fiebre hemorrágica con síndrome renal","synonyms":["Fiebre por hantavirus","Hantaviriasis"],"definition":"Es una enfermedad hemorrágica poco frecuente transmitida por roedores, potencialmente grave, causada por hantavirus del Viejo Mundo y caracterizada por fiebre alta, malestar general, cefalea, mialgia, artralgia, dolor de espalda, dolor abdominal, oliguria/ insuficiencia renal y manifestaciones hemorrágicas sistémicas."},"it":{"name":"Febbre emorragica con sindrome renale","synonyms":["Febbre da hantavirus","Hantavirosi"]},"nl":{"name":"Hemorragische koorts - renaal syndroom","synonyms":["Hantavirose","Koorts door hantavirus"],"definition":"Een zeldzame door knaagdieren overgedragen, potentieel ernstige hemorragische aandoening veroorzaakt door hantavirussen uit de Oude Wereld, gekenmerkt door hoge koorts, malaise, hoofdpijn, myalgie, artralgie, rugpijn, abdominale pijn, oligurie/nierfalen, en systemische hemorragische manifestaties."},"pt":{"name":"Febre hemorrágica com nefropatia","synonyms":["Febre por hantavírus","Hantavirose"]},"pl":{"name":"Gorączka krwotoczna - zespół nerkowy","synonyms":["Gorączka hantawirusowa","Zakażenie hantawirusowe"],"definition":"Rzadka, potencjalnie ciężka skaza krwotoczna przenoszona przez gryzonie, wywoływana przez Hantawirusy Starego Świata, charakteryzująca się wysoką gorączką, złym samopoczuciem, bólem głowy, bólem mięśni, bólem stawów, bólem pleców, bólem brzucha, skąpomoczem/niewydolnością nerek i ogólnoustrojowymi objawami krwotocznymi."},"cs":{"name":"Hemoragická horečka s ledvinovým syndromem","synonyms":["Hantaviróza","Hantavirová horečka"]},"uk":{"name":"Геморагічна лихоманка - нирковий синдром","synonyms":["Хантавіроз","Хантавірусна лихоманка"],"definition":"A rare rodent-borne, potentially severe, hemorrhagic disease caused by Old World Hantaviruses characterized by high fever, malaise, headache, myalgia, arthralgia, backache, abdominal pain, oliguria/renal failure and systemic hemorrhagic manifestations."},"zh":{"name":"肾综合征出血热","synonyms":["汉坦病毒热"]},"tr":{"name":"Hemorajik ateş-böbrek sendromu","synonyms":["Hantaviroz","Hantavirüs ateşi"]}},"xrefs":[{"source":"ICD-10","code":"A98.5+","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"N08.0*","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"1D62.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1059069619"},{"source":"MONDO","code":"0018081","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C535630","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2930957","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10023484","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.74,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.32,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.52,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.5,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.92,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.78,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.06,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.2,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2012-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.36,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":29.16,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.18,"area":"France","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.16,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.08,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.3,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.44,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.02,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.24,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2011-2015[OTHER]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":37.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2004[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-08-27","source":"24750436[PMID]_32809495[PMID]_26870699[PMID]","terms":[{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0030005","label":"Capillary leak","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012213","label":"Decreased glomerular filtration rate","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011037","label":"Decreased urine output","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003259","label":"Elevated circulating creatinine concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100520","label":"Oliguria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032169","label":"Severe infection","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004729","label":"Acute tubulointerstitial nephritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003418","label":"Back pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004325","label":"Decreased body weight","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001262","label":"Excessive daytime somnolence","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000099","label":"Glomerulonephritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030783","label":"Increased circulating interleukin 6 concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001962","label":"Palpitations","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000967","label":"Petechiae","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000093","label":"Proteinuria","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001970","label":"Tubulointerstitial nephritis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000713","label":"Agitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001903","label":"Anemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100519","label":"Anuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031364","label":"Ecchymosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002248","label":"Hematemesis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002153","label":"Hyperkalemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002905","label":"Hyperphosphatemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031273","label":"Shock","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011896","label":"Subconjunctival hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012622","label":"Chronic kidney disease","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011029","label":"Internal hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002170","label":"Intracranial hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002249","label":"Melena","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Very rare (<4-1%)","criteria":null}]}}