ORPHA:3389
Tuberculosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Tuberculosis (TB) is a contagious-infectious disease caused mainly by <i>Mycobacterium tuberculosis</i> that in most individuals is usually asymptomatic but that in at risk individuals (e.g. with diabetes or with HIV infection) can cause weakness, fever, weight loss, night sweat, and respiratory anomalies such as chronic cough, chest pain, hemoptysis or respiratory insufficiency.
1
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tuberculosis | |
| fr | Tuberculose | |
| de | Tuberkulose | |
| es | Tuberculosis | |
| it | Tubercolosi | |
| nl | Tuberculose | |
| pt | Tuberculose | |
| pl | Gruźlica | |
| cs | Tuberkulóza | |
| uk | Туберкульоз | |
| zh | 结核 | |
| tr | Tüberküloz |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 607948 | BTNT | validated | |
| ICD-10 | A15 | BTNT | attributed | validated |
| ICD-10 | A16 | BTNT | attributed | validated |
| MONDO | 0018076 | E | validated | |
| MONDO | 18076 | E | validated | |
| MeSH | D014376 | E | validated | |
| UMLS | C0041296 | E | validated | |
| MedDRA | 10044755 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
3
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163582Rare bacterial infectious disease
rare infectious diseases
4
Genes
0 direct · 1 via subtypesOrphanet records no gene directly on this code.
Recorded by Orphanet on subtypes of this disorder:
| Gene | Subtype | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|---|
| SLC11A1 | ORPHA:645814Primary pulmonary tuberculosis | Major susceptibility factor in | Assessed | HGNC:10907 | ENSG00000018280 | 600266 | 2q35 | solute carrier family 11 member 1 | 42163977[PMID] |
5
Prevalence and incidence
40 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 4 / 100 000 | France | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 8 / 100 000 | Finland | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 18 / 100 000 | Hungary | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | >1 / 1000 | 181 / 100 000 | India | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 7 / 100 000 | Netherlands | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 14 / 100 000 | United Kingdom | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 6 / 100 000 | Norway | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 7 / 100 000 | Sweden | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 6-9 / 10 000 | 75 / 100 000 | China | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 47 / 100 000 | Latin America | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | >1 / 1000 | 993 / 100 000 | South Africa | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 7.1 / 100 000 | Denmark | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 6 / 100 000 | Czech Republic | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 5 / 100 000 | Germany | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 10.7 / 100 000 | Ireland | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 3 / 100 000 | Italy | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 25 / 100 000 | Estonia | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 24 / 100 000 | Turkey | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 6-9 / 10 000 | 89 / 100 000 | Ukraine | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 9 / 100 000 | Europe | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 4 / 100 000 | Greece | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 5 / 100 000 | Iceland | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 6 / 100 000 | Israel | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 15 / 100 000 | Spain | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 24 / 100 000 | Portugal | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 8 / 100 000 | Belgium | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 4 / 100 000 | Austria | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 6-9 / 10 000 | 90 / 100 000 | Algeria | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 23 / 100 000 | Poland | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 42 / 100 000 | Latvia | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 59 / 100 000 | Lithuania | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 49 / 100 000 | Bosnia and Herzegovina | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 17 / 100 000 | Croatia | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | >1 / 1000 | 101 / 100 000 | Romania | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 6-9 / 10 000 | 97 / 100 000 | Russian Federation | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | >1 / 1000 | 139 / 100 000 | Worldwide | Value and class | Validated | 21420560[PMID] |
| Point prevalence | 1-5 / 10 000 | 16 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2018[OTHER] |
| Annual incidence | 1-9 / 100 000 | 3.4 / 100 000 | United States | Value and class | Validated | Centers for Disease Control and Prevention 2011[OTHER] |
| Annual incidence | 1-5 / 10 000 | 20 / 100 000 | Japan | Value and class | Validated | World Health Organization 2011[OTHER] |
| Annual incidence | 1-9 / 100 000 | 6 / 100 000 | Australia | Value and class | Validated | World Health Organization 2011[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
6
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
7
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/3389
- This record as JSON: /data/d/3389.json