{"orpha":3389,"name":"Tuberculosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Tuberculosis (TB) is a contagious-infectious disease caused mainly by <i>Mycobacterium tuberculosis</i> that in most individuals is usually asymptomatic but that in at risk individuals (e.g. with diabetes or with HIV infection) can cause weakness, fever, weight loss, night sweat, and respiratory anomalies such as chronic cough, chest pain, hemoptysis or respiratory insufficiency.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-3389/","orphanet_url":"https://www.orpha.net/en/disease/detail/3389","names":{"fr":{"name":"Tuberculose","definition":"La tuberculose est une maladie infectieuse contagieuse causée principalement par <i>Mycobacterium tuberculosis</i>. Elle est habituellement asymptomatique chez la plupart des individus, mais chez les personnes à risque (ex. diabétiques ou infectées par le VIH), elle peut causer une asthénie, une fièvre, une perte de poids, des sueurs nocturnes et des anomalies respiratoires telles qu'une toux chronique, une douleur thoracique, une hémoptysie ou une insuffisance respiratoire."},"de":{"name":"Tuberkulose","definition":"Tuberkulose (TB) ist eine ansteckende Infektionskrankheit, die hauptsächlich durch <i>Mycobacterium tuberculosis</i> verursacht wird. Sie ist bei den meisten Menschen asymptomatisch, kann jedoch bei Risikopatienten (z.B. bei Diabetes oder HIV-Infektion) Schwäche, Fieber, Gewichtsverlust, Nachtschweiß und Atemwegsanomalien wie chronischer Husten, Brustschmerzen, Hämoptyse oder respiratorische Insuffizienz hervorrufen."},"es":{"name":"Tuberculosis","definition":"Es una enfermedad infectocontagiosa causada principalmente por&#160;<i>Mycobacterium tuberculosis</i>&#160;que en la mayoría de las personas suele ser asintomática, pero que en pacientes de riesgo (como pacientes con diabetes o con infección por VIH) puede causar debilidad, fiebre, pérdida de peso, sudoración nocturna y anomalías respiratorias como tos crónica, dolor torácico, hemoptisis o insuficiencia respiratoria."},"it":{"name":"Tubercolosi"},"nl":{"name":"Tuberculose","definition":"Tuberculose (TB) is een besmettelijke infectieziekte, voornamelijk veroorzaakt door <i>Mycobacterium tuberculosis</i>, die in de meeste individuen asymptomatisch is, maar die in individuen die risico lopen (bvb. met diabetes of HIV-infectie) zwakte, koorts, gewichtsverlies, nachtzweten, en ademhalingsstoornissen zoals chronische hoest, pijn op de borst, hemoptoë of respiratoire insufficiëntie kan veroorzaken."},"pt":{"name":"Tuberculose"},"pl":{"name":"Gruźlica"},"cs":{"name":"Tuberkulóza"},"uk":{"name":"Туберкульоз","definition":"Tuberculosis (TB) is a contagious-infectious disease caused mainly by <i>Mycobacterium tuberculosis</i> that in most individuals is usually asymptomatic but that in at risk individuals (e.g. with diabetes or with HIV infection) can cause weakness, fever, weight loss, night sweat, and respiratory anomalies such as chronic cough, chest pain, hemoptysis or respiratory insufficiency."},"zh":{"name":"结核"},"tr":{"name":"Tüberküloz"}},"xrefs":[{"source":"OMIM","code":"607948","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"A15","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"A16","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0018076","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"18076","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014376","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0041296","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10044755","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[{"orpha":645854,"name":"Multifocal tuberculosis","type":"Clinical subtype"},{"orpha":730702,"name":"Primary extra-pulmonary tuberculosis","type":"Clinical subtype"},{"orpha":645814,"name":"Primary pulmonary tuberculosis","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[{"symbol":"SLC11A1","name":"solute carrier family 11 member 1","gene_type":"gene with protein product","association":"Major susceptibility factor in","status":"Assessed","source":"42163977[PMID]","hgnc":"10907","ensembl":"ENSG00000018280","omim":"600266","loci":["2q35"],"via":{"orpha":645814,"name":"Primary pulmonary tuberculosis"}}],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.0,"area":"France","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.0,"area":"Finland","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":18.0,"area":"Hungary","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":181.0,"area":"India","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":7.0,"area":"Netherlands","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":14.0,"area":"United Kingdom","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.0,"area":"Norway","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":7.0,"area":"Sweden","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"6-9 / 10 000","value":75.0,"area":"China","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":47.0,"area":"Latin America","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":993.0,"area":"South Africa","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":7.1,"area":"Denmark","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.0,"area":"Czech Republic","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.0,"area":"Germany","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.7,"area":"Ireland","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.0,"area":"Italy","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":25.0,"area":"Estonia","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":24.0,"area":"Turkey","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"6-9 / 10 000","value":89.0,"area":"Ukraine","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":9.0,"area":"Europe","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.0,"area":"Greece","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.0,"area":"Iceland","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.0,"area":"Israel","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":15.0,"area":"Spain","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":24.0,"area":"Portugal","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.0,"area":"Belgium","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.0,"area":"Austria","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"6-9 / 10 000","value":90.0,"area":"Algeria","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":23.0,"area":"Poland","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":42.0,"area":"Latvia","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":59.0,"area":"Lithuania","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":49.0,"area":"Bosnia and Herzegovina","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":17.0,"area":"Croatia","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":101.0,"area":"Romania","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"6-9 / 10 000","value":97.0,"area":"Russian Federation","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":139.0,"area":"Worldwide","status":"Validated","source":"21420560[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":16.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.4,"area":"United States","status":"Validated","source":"Centers for Disease Control and Prevention 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":20.0,"area":"Japan","status":"Validated","source":"World Health Organization 2011[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.0,"area":"Australia","status":"Validated","source":"World Health Organization 2011[OTHER]"}],"phenotypes":null}