ORPHA:319218

Ebola hemorrhagic fever

Synonyms: EHF · Ebola fever · Ebola virus disease

Type: Disease
Group: Disorder
Inheritance: Not applicable
Age of onset: All ages
Status: active

Ebola hemorrhagic fever (EHF), caused by Ebola virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.

Names in Orphadata languages

12 of 12 languages

Lang	Name	Synonyms
en	Ebola hemorrhagic fever	EHF · Ebola fever · Ebola virus disease
fr	Fièvre hémorragique à virus Ebola	EHF · Fièvre Ebola
de	Ebola hämorrhagisches Fieber	EHF · Ebola-Fieber · Ebola-Viruskrankheit
es	Fiebre hemorrágica del virus Ébola	Enfermedad del virus Ébola · Fiebre del Ébola · EHF
it	Febbre emorragica dell'Ebola	EHF · Febbre dell'Ebola · Malattia virale dell'Ebola
nl	Ebola hemorragische koorts	EHF · Ebola-koorts · Ebola-virusziekte
pt	Febre hemorrágica do Ébola
pl	Gorączka krwotoczna Ebola	Choroba wirusa Ebola · EHF · Gorączka ebola Ebola
cs	Hemoragická horečka Ebola	EHF · Virová nemoc Ebola · Horečka Ebola
uk	Геморагічна лихоманка Ебола	Лихоманка Ебола · Хвороба, спричинена вірусом Ебола · EHF
zh	埃博拉出血热	埃博拉病毒病
tr	Ebola hemorajik ateşi	EHF · Ebola ateşi · Ebola virüsü hastalığı

Definition in:

Cross-references

qualifier = Orphanet mapping relation

Source	Code	Qualifier	ICD relation	Validation
ICD-10	A98.4	E	specific	validated
ICD-11	1D60.01	E	specific	validated
MONDO	0005737	E		validated
MeSH	D019142	E		validated
UMLS	C0282687	E		validated
GARD	2035	E		validated
MedDRA	10014071	E		validated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

Classification

Preferential parent (Orphanet linearisation):

ORPHA:68416Rare infectious disease

Parents in the classifications (1):

ORPHA:341Viral hemorrhagic fever
rare infectious diseases

No children.

Genes

0 direct

Orphanet records no gene directly on this code.

Prevalence and incidence

3 records

Type	Class	Value	Area	Qualification	Validation	Source
Cases/families		28220 cases	Worldwide	Case(s)	Validated	World health Organisation 2015[OTHER]_26607790[PMID]
Annual incidence	<1 / 1 000 000	—	Europe	Class only	Validated	European Centre for Disease prevention and Control 2011[OTHER]
Point prevalence	<1 / 1 000 000	—	Europe	Class only	Validated	European Medicines Agency 2018[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

HPO phenotypes

29 annotations · validated 2021-09-06

HPO	Term (as annotated by Orphanet)	Diagnostic
Very frequent (99-80%)
HP:0100749	Chest pain
HP:0002014	Diarrhea
HP:0001945	Fever
HP:0010702	Increased circulating immunoglobulin concentration
HP:0020071	Viremia
Frequent (79-30%)
HP:0002027	Abdominal pain
HP:0001892	Abnormal bleeding
HP:0025143	Chills
HP:0012735	Cough
HP:0002015	Dysphagia
HP:0002239	Gastrointestinal hemorrhage
HP:0002315	Headache
HP:0012115	Hepatitis
HP:0001882	Leukopenia
HP:0001888	Lymphopenia
HP:0040186	Maculopapular exanthema
HP:0002249	Melena
HP:0002018	Nausea
HP:0025439	Pharyngitis
HP:0004396	Poor appetite
HP:0100806	Sepsis
HP:0002013	Vomiting
Occasional (29-5%)
HP:0001735	Acute pancreatitis
HP:0002829	Arthralgia
HP:0005521	Disseminated intravascular coagulation
HP:0002094	Dyspnea
HP:0001254	Lethargy
HP:0100247	Recurrent singultus
HP:0001873	Thrombocytopenia

Run the differential on the 5 obligate / very frequent terms

Annotation source: 26287303[PMID]_32487785[PMID]_28653186[PMID]

Sources for this card

Orphanet page: orpha.net/en/disease/detail/319218
This record as JSON: /data/d/319218.json