{"orpha":319218,"name":"Ebola hemorrhagic fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["EHF","Ebola fever","Ebola virus disease"],"definition":"Ebola hemorrhagic fever (EHF), caused by Ebola virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-319218/","orphanet_url":"https://www.orpha.net/en/disease/detail/319218","names":{"fr":{"name":"Fièvre hémorragique à virus Ebola","synonyms":["EHF","Fièvre Ebola"],"definition":"La fièvre hémorragique à virus Ebola (FHE), provoquée par le virus Ebola, est une maladie hémorragique virale caractérisée par un début avec fièvre et malaise suivi par un tableau de symptômes gastro-intestinaux, de saignements, de choc et de défaillance multi-viscérale."},"de":{"name":"Ebola hämorrhagisches Fieber","synonyms":["EHF","Ebola-Fieber","Ebola-Viruskrankheit"],"definition":"Das Ebola hämorrhagische Fieber (EHF), verursacht durch das Ebola-Virus, ist eine schwere hämorrhagische Erkrankung, die durch anfängliches Fieber und Unwohlsein, gefolgt von gastrointestinalen Symptomen, Blutungen, Schock und Multiorganversagen gekennzeichnet ist."},"es":{"name":"Fiebre hemorrágica del virus Ébola","synonyms":["Enfermedad del virus Ébola","Fiebre del Ébola","EHF"],"definition":"La fiebre hemorrágica del Ébola (EHF), causada por el virus del Ébola, es una enfermedad hemorrágica vírica grave que se caracteriza por fiebre inicial y malestar, seguido de síntomas gastrointestinales, sangrado, shock y fallo sistémico multiorgánico."},"it":{"name":"Febbre emorragica dell'Ebola","synonyms":["EHF","Febbre dell'Ebola","Malattia virale dell'Ebola"],"definition":"La febbre emorragica Ebola, causata dal virus Ebola, è una grave malattia emorragica virale caratterizzata da febbre e malessere iniziali, seguiti da sintomi gastrointestinali, emorragie, shock, e insufficienza sistemica multi-organo."},"nl":{"name":"Ebola hemorragische koorts","synonyms":["EHF","Ebola-koorts","Ebola-virusziekte"],"definition":"Ebola hemorragische koorts (EHF), veroorzaakt door het Ebolavirus, is een ernstige virale hemorragische ziekte die gekenmerkt wordt door initiële koorts en malaise, gevolgd door gastro-intestinale symptomen, bloeding, shock en multi-orgaanfalen."},"pt":{"name":"Febre hemorrágica do Ébola"},"pl":{"name":"Gorączka krwotoczna Ebola","synonyms":["Choroba wirusa Ebola","EHF","Gorączka ebola Ebola"]},"cs":{"name":"Hemoragická horečka Ebola","synonyms":["EHF","Virová nemoc Ebola","Horečka Ebola"]},"uk":{"name":"Геморагічна лихоманка Ебола","synonyms":["Лихоманка Ебола","Хвороба, спричинена вірусом Ебола","EHF"],"definition":"Ebola hemorrhagic fever (EHF), caused by Ebola virus, is a severe viral hemorrhagic disease characterized by initial fever and malaise followed by gastrointestinal symptoms, bleeding, shock, and multi-organ system failure."},"zh":{"name":"埃博拉出血热","synonyms":["埃博拉病毒病"],"definition":"埃博拉出血热（EHF）是由埃博拉病毒引起的一种严重的病毒性出血热，其特征是先发热、不适，随后出现胃肠道症状、出血、休克和多器官系统衰竭。"},"tr":{"name":"Ebola hemorajik ateşi","synonyms":["EHF","Ebola ateşi","Ebola virüsü hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A98.4","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1D60.01","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"792755706"},{"source":"MONDO","code":"0005737","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D019142","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0282687","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"2035","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10014071","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":28220.0,"area":"Worldwide","status":"Validated","source":"World health Organisation 2015[OTHER]_26607790[PMID]"},{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-09-06","source":"26287303[PMID]_32487785[PMID]_28653186[PMID]","terms":[{"hpo":"HP:0100749","label":"Chest pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010702","label":"Increased circulating immunoglobulin concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0020071","label":"Viremia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001892","label":"Abnormal bleeding","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002239","label":"Gastrointestinal hemorrhage","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012115","label":"Hepatitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001888","label":"Lymphopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002249","label":"Melena","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025439","label":"Pharyngitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004396","label":"Poor appetite","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001735","label":"Acute pancreatitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100247","label":"Recurrent singultus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Occasional (29-5%)","criteria":null}]}}