Lujo hemorrhagic fever
Synonyms: Zambian hemorrhagic fever
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Lujo hemorrhagic fever | Zambian hemorrhagic fever |
| fr | Fièvre hémorragique à arénavirus Lujo | Fièvre hémorragique zambienne |
| de | Lujo hämorrhagisches Fieber | Sambesisches hämorrhagisches Fieber |
| es | Fiebre hemorrágica del virus Lujo | Fiebre hemorrágica de Zambia |
| it | Febbre emorragica di Lujo | Febbre emorragica del Zambia |
| nl | Lujo hemorragische koorts | Zambiaanse hemorragische koorts |
| pt | Febre hemorrágica de Lujo | |
| pl | Gorączka krwotoczna Lujo | Zambijska gorączka krwotoczna |
| cs | Lujo hemoragická horečka | Zambijská hemoragická horečka |
| uk | Геморагічна лихоманка Лухо | Замбійська геморагічна лихоманка |
| zh | 卢霍出血热 | 赞比亚出血热 |
| tr | Lujo hemorajik ateşi | Zambiya hemorajik ateşi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A96.8 | NTBT | attributed | validated |
| ICD-11 | 1D6Y | NTBT | index | validated |
| MONDO | 0017872 | E | validated | |
| MeSH | C000723471 | E | validated | |
| UMLS | C4274433 | E | validated | |
| MedDRA | 10079325 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:341Viral hemorrhagic fever
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 5 cases | Worldwide | Case(s) | Validated | 29733163[PMID]_ORPHANET | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | 29733163[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
59 annotations · validated 2021-09-06| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002014 | Diarrhea | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0000282 | Facial edema | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0003326 | Myalgia | |
| HP:0025439 | Pharyngitis | |
| HP:0031691 | Severe viral infection | |
| HP:0025258 | Stiff neck | |
| HP:0001873 | Thrombocytopenia | |
| Frequent (79-30%) | ||
| HP:0000707 | Abnormality of the nervous system | |
| HP:0100749 | Chest pain | |
| HP:0001259 | Coma | |
| HP:0001289 | Confusion | |
| HP:0031364 | Ecchymosis | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0007430 | Generalized edema | |
| HP:0025435 | Increased circulating lactate dehydrogenase concentration | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0001882 | Leukopenia | |
| HP:0001888 | Lymphopenia | |
| HP:0040186 | Maculopapular exanthema | |
| HP:0001942 | Metabolic acidosis | |
| HP:0002907 | Microscopic hematuria | |
| HP:0002018 | Nausea | |
| HP:0100520 | Oliguria | |
| HP:0003645 | Prolonged partial thromboplastin time | |
| HP:0000083 | Renal insufficiency | |
| HP:0031273 | Shock | |
| HP:0000988 | Skin rash | |
| HP:0011896 | Subconjunctival hemorrhage | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0032155 | Abdominal cramps | |
| HP:0000739 | Anxiety | |
| HP:0100750 | Atelectasis | |
| HP:0002069 | Bilateral tonic-clonic seizure | |
| HP:0001662 | Bradycardia | |
| HP:0002181 | Cerebral edema | |
| HP:0030830 | Crackles | |
| HP:0002329 | Drowsiness | |
| HP:0002015 | Dysphagia | |
| HP:0030139 | Excessive bleeding after a venipuncture | |
| HP:0004787 | Fulminant hepatitis | |
| HP:0000975 | Hyperhidrosis | |
| HP:0002615 | Hypotension | |
| HP:0001268 | Mental deterioration | |
| HP:0001324 | Muscle weakness | |
| HP:0012819 | Myocarditis | |
| HP:0031246 | Nonproductive cough | |
| HP:0032043 | Odynophagia | |
| HP:0100539 | Periorbital edema | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0000613 | Photophobia | |
| HP:0000979 | Purpura | |
| HP:0002098 | Respiratory distress | |
| HP:0002322 | Resting tremor | |
| HP:0012384 | Rhinitis | |
| HP:0025145 | Rigors | |
| HP:0001250 | Seizure | |
Run the differential on the 10 obligate / very frequent terms
Annotation source: 25393244[PMID]_27593704[PMID]_29120740[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/319213
- This record as JSON: /data/d/319213.json