{"orpha":319213,"name":"Lujo hemorrhagic fever","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Zambian hemorrhagic fever"],"definition":"Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-319213/","orphanet_url":"https://www.orpha.net/en/disease/detail/319213","names":{"fr":{"name":"Fièvre hémorragique à arénavirus Lujo","synonyms":["Fièvre hémorragique zambienne"],"definition":"Zoonose originaire de Zambie, en Afrique, causée par le virus Lujo (un arénavirus de l'Ancien Monde récemment découvert) dont le réservoir est inconnu, caractérisée par une fièvre et des manifestations hémorragiques avec un taux de létalité extrêmement élevé de 80&nbsp;% (dans les 5&nbsp;cas rapportés à ce jour) et un taux de transmission nosocomiale modéré à élevé."},"de":{"name":"Lujo hämorrhagisches Fieber","synonyms":["Sambesisches hämorrhagisches Fieber"]},"es":{"name":"Fiebre hemorrágica del virus Lujo","synonyms":["Fiebre hemorrágica de Zambia"],"definition":"La fiebre hemorrágica de Lujo, causada por el virus Lujo (un arenavirus del Viejo Mundo) es una enfermedad zoonótica de Zambia, África, cuyo reservorio se desconoce y que está caracterizado por fiebre y manifestaciones hemorrágicas con una tasa de mortalidad extremadamente alta del 80% (en los 5 casos descritos hasta la fecha) y un nivel moderado a alto de transmisión nosocomial."},"it":{"name":"Febbre emorragica di Lujo","synonyms":["Febbre emorragica del Zambia"]},"nl":{"name":"Lujo hemorragische koorts","synonyms":["Zambiaanse hemorragische koorts"],"definition":"Lujo hemorragische koorts, veroorzaakt door het Lujovirus (een nieuw ontdekt arenavirus van de Oude Wereld), is een zoönotische ziekte uit Zambia, Afrika, waarvan het reservoir niet bekend is en die gekenmerkt wordt door koorts en hemorragische manifestaties met een extreem hoog sterftecijfer van 80% (in de 5 gevallen tot nu toe gerapporteerd) en een matig tot hoog niveau van nosocomiale transmissie."},"pt":{"name":"Febre hemorrágica de Lujo"},"pl":{"name":"Gorączka krwotoczna Lujo","synonyms":["Zambijska gorączka krwotoczna"]},"cs":{"name":"Lujo hemoragická horečka","synonyms":["Zambijská hemoragická horečka"]},"uk":{"name":"Геморагічна лихоманка Лухо","synonyms":["Замбійська геморагічна лихоманка"],"definition":"Lujo hemorrhagic fever, caused by the Lujo virus (a newly discovered Old World arenavirus) is a zoonotic disease from Zambia, Africa, whose reservoir is unknown and is characterized by fever and hemorrhagic manifestations with an extremely high fatality rate of 80% (in the 5 reported cases to date) and a moderate to high level of nosocomial transmission."},"zh":{"name":"卢霍出血热","synonyms":["赞比亚出血热"],"definition":"Lujo出血热，由Lujo病毒（一种新发现的旧大陆砂状病毒）引起，是一种来自非洲赞比亚的人畜共患病，其宿主未知，以发热和出血为特征，病死率极高，达80%（迄今为止报告的5例病例中），医院传播水平为中到高。"},"tr":{"name":"Lujo hemorajik ateşi","synonyms":["Zambiya hemorajik ateşi"]}},"xrefs":[{"source":"ICD-10","code":"A96.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1D6Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1877776449"},{"source":"MONDO","code":"0017872","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C000723471","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4274433","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10079325","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":341,"name":"Viral hemorrhagic fever","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":5.0,"area":"Worldwide","status":"Validated","source":"29733163[PMID]_ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"29733163[PMID]_ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-09-06","source":"25393244[PMID]_27593704[PMID]_29120740[PMID]","terms":[{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000282","label":"Facial edema","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very 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