Acquired prothrombin deficiency
Synonyms: Acquired hypoprothrombinemia
- Type
- Disease
- Group
- Disorder
- Age of onset
- Childhood, Infancy
- Status
- active
A rare hemorrhagic disorder characterized by decreased factor II plasma levels in association with severe liver disease, vitamin K deficiency, or vitamin K antagonist treatment, or in the context of other conditions such as systemic lupus erythematosus, primary antiphospholipid syndrome, or infections. Patients present with increased bleeding tendency leading to easy bruising, frequent nosebleeds, hemorrhaging after surgery or trauma, and heavy menstrual bleeding, among others. Joint bleeding is uncommon.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acquired prothrombin deficiency | Acquired hypoprothrombinemia |
| fr | Déficit acquis en facteur II | Hypoprothrombinémie acquise |
| de | Faktor II-Mangel, erworbener | Hypoprothrombinämie, erworbene · Prothrombin-Mangel, erworbener |
| es | Deficiencia adquirida de factor II | |
| it | Deficit acquisito del fattore II | Ipoprotrombinemia acquisita |
| nl | Verworven protrombinedeficiëntie | Verworven hypoprotrombinemie |
| pt | Deficiência de protrombina adquirida | Hipoprotrombinemia adquirida |
| pl | Nabyty Niedobór protrombiny | Hipoprotrombinemia nabyta |
| cs | Získaný deficit protrombinu | Získaná hypoprotrombinémie |
| uk | Набутий дефіцит протромбіну | Набута гіпопротромбінемія |
| zh | 获得性凝血酶原缺乏症 | 获得性低凝血酶原血症 |
| tr | Edinsel protrombin eksikliği | Edinsel hipoprotrombinemi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D68.4 | NTBT | attributed | validated |
| ICD-11 | 3B2Y | NTBT | index | validated |
| MONDO | 0016990 | E | validated | |
| MeSH | C538174 | E | validated | |
| UMLS | C0392610 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:166775Rare hemorrhagic disorder due to an acquired coagulation factor defect
rare hematological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | 0.05 / 100 000 | Worldwide | Value and class | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/26348
- This record as JSON: /data/d/26348.json