{"orpha":26348,"name":"Acquired prothrombin deficiency","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Acquired hypoprothrombinemia"],"definition":"A rare hemorrhagic disorder characterized by decreased factor II plasma levels in association with severe liver disease, vitamin K deficiency, or vitamin K antagonist treatment, or in the context of other conditions such as systemic lupus erythematosus, primary antiphospholipid syndrome, or infections. Patients present with increased bleeding tendency leading to easy bruising, frequent nosebleeds, hemorrhaging after surgery or trauma, and heavy menstrual bleeding, among others. Joint bleeding is uncommon.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-26348/","orphanet_url":"https://www.orpha.net/en/disease/detail/26348","names":{"fr":{"name":"Déficit acquis en facteur II","synonyms":["Hypoprothrombinémie acquise"],"definition":"Maladie hémorragique rare caractérisée par de faibles taux plasmatiques de facteur II en association avec une maladie hépatique sévère, un déficit en vitamine K ou un traitement par anti-vitamine K, ou survenant dans le contexte d'autres maladies telles qu'un lupus érythémateux systémique, un syndrome primaire des antiphospholipides ou des infections. Les patients ont une tendance accrue aux saignements qui entraîne, entre autres, une tendance aux ecchymoses, des saignements de nez fréquents, des hémorragies après une chirurgie ou un traumatisme et des pertes menstruelles abondantes. Les cas d'hémorragie articulaire sont rares."},"de":{"name":"Faktor II-Mangel, erworbener","synonyms":["Hypoprothrombinämie, erworbene","Prothrombin-Mangel, erworbener"]},"es":{"name":"Deficiencia adquirida de factor II","definition":"Es un trastorno hemorrágico poco frecuente caracterizado por una disminución de los niveles plasmáticos de factor II en asociación con enfermedad hepática grave, deficiencia de vitamina K o tratamiento con antagonistas de la vitamina K, o en el contexto de otras afecciones como lupus eritematoso sistémico, síndrome antifosfolipídido primario o infecciones. Los pacientes presentan una mayor tendencia al sangrado, lo que provoca hematomas con facilidad, hemorragias nasales frecuentes, hemorragias después de una cirugía o traumatismo y sangrado menstrual abundante, entre otros. El sangrado articular es poco común."},"it":{"name":"Deficit acquisito del fattore II","synonyms":["Ipoprotrombinemia acquisita"]},"nl":{"name":"Verworven protrombinedeficiëntie","synonyms":["Verworven hypoprotrombinemie"],"definition":"Een zeldzame stollingsstoornis, gekenmerkt door verlaagde gehaltes van factor II in plasma in associatie met ernstige leverziekte, vitamine K-deficiëntie, of behandeling met vitamine K-antagonist, of in de context van een andere aandoening zoals systemische lupus erythematosus, primair antifosfolipidensyndroom, of infectie. Patiënten presenteren zich met verhoogde bloedingsneiging, wat leidt tot onder meer gevoeligheid voor kneuzing, frequente neusbloedingen, hemorragie na chirurgie of trauma, en hevige menstruele bloeding. Bloeding van gewricht is uitzonderlijk."},"pt":{"name":"Deficiência de protrombina adquirida","synonyms":["Hipoprotrombinemia adquirida"]},"pl":{"name":"Nabyty Niedobór protrombiny","synonyms":["Hipoprotrombinemia nabyta"]},"cs":{"name":"Získaný deficit protrombinu","synonyms":["Získaná hypoprotrombinémie"]},"uk":{"name":"Набутий дефіцит протромбіну","synonyms":["Набута гіпопротромбінемія"],"definition":"A rare hemorrhagic disorder characterized by decreased factor II plasma levels in association with severe liver disease, vitamin K deficiency, or vitamin K antagonist treatment, or in the context of other conditions such as systemic lupus erythematosus, primary antiphospholipid syndrome, or infections. Patients present with increased bleeding tendency leading to easy bruising, frequent nosebleeds, hemorrhaging after surgery or trauma, and heavy menstrual bleeding, among others. Joint bleeding is uncommon."},"zh":{"name":"获得性凝血酶原缺乏症","synonyms":["获得性低凝血酶原血症"]},"tr":{"name":"Edinsel protrombin eksikliği","synonyms":["Edinsel hipoprotrombinemi"]}},"xrefs":[{"source":"ICD-10","code":"D68.4","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"3B2Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1291939300"},{"source":"MONDO","code":"0016990","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C538174","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0392610","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":166775,"name":"Rare hemorrhagic disorder due to an acquired coagulation factor defect","classifications":[194]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Childhood","Infancy"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.05,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}