Apnea of prematurity
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Infancy, Neonatal
- Status
- active
A developmental disorder affecting premature infants, likely secondary to an immaturity of respiratory control resulting in idiopathic pauses in breathing often associated with reduced heart rate and arterial blood oxygen levels. It may be exacerbated by concurrent neonatal diseases.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Apnea of prematurity | |
| fr | Apnée du prématuré | |
| de | Frühgeborenen-Apnoe | AOP |
| es | Apnea de la prematuridad | |
| it | Apnea del prematuro | |
| nl | Apneu door prematuriteit | |
| pt | Apneia da prematuridade (AOP) | |
| pl | Bezdech wcześniaków | |
| cs | Apnoe předčasně narozených | |
| uk | Апное недоношених | |
| zh | 早产儿呼吸暂停 | |
| tr | Prematüre apnesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P28.4 | NTBT | index | validated |
| ICD-11 | 7A40.2 | E | specific | validated |
| MONDO | 0020567 | E | validated | |
| UMLS | C0475715 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:101944Rare pulmonary disease
rare respiratory diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 8.5 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2003[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
5 annotations · validated 2024-10-11| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002104 | Apnea | |
| Frequent (79-30%) | ||
| HP:0001662 | Bradycardia | |
| HP:0000961 | Cyanosis | |
| HP:0012418 | Hypoxemia | |
| Occasional (29-5%) | ||
| HP:0001531 | Failure to thrive in infancy | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 35251853[PMID]_23720269[PMID]_28722998[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/99981
- This record as JSON: /data/d/99981.json