{"orpha":99981,"name":"Apnea of prematurity","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A developmental disorder affecting premature infants, likely secondary to an immaturity of respiratory control resulting in idiopathic pauses in breathing often associated with reduced heart rate and arterial blood oxygen levels. It may be exacerbated by concurrent neonatal diseases.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99981/","orphanet_url":"https://www.orpha.net/en/disease/detail/99981","names":{"fr":{"name":"Apnée du prématuré","definition":"L'apnée du prématuré est un trouble du développement affectant les prématurés, probablement secondaire à une immaturité du contrôle de la respiration, résultant en des apnées souvent associées à une bradycardie et une hypoxie. Elle peut être exacerbée par des maladies néonatales concomitantes."},"de":{"name":"Frühgeborenen-Apnoe","synonyms":["AOP"],"definition":"Die Frühgeborenen-Apnoe ist eine Entwicklungsstörung frühgeborene Kinder, wahrscheinlich als Folge unreifer Atmungskontrolle. Sie führt zu idiopathische Atempausen, oft in Verbindung mit verlangsamtem Herzschlag und vermindertem Sauerstoffspiegel des arteriellen Blutes. Durch gleichzeitig bestehende andere Krankheiten wird sie verstärkt."},"es":{"name":"Apnea de la prematuridad","definition":"Es un trastorno del desarrollo que afecta a niños prematuros, probablemente secundario a una inmadurez del control de la respiración que da lugar a pausas idiopáticas en la respiración a menudo asociadas con una frecuencia cardíaca reducida y unos niveles de oxígeno en sangre arterial reducidos también. Puede recrudecerse por enfermedades neonatales concurrentes."},"it":{"name":"Apnea del prematuro","definition":"L'apnea del prematuro è un difetto dello sviluppo che interessa i neonati prematuri ed è probabilmente secondaria all'immaturità del controllo respiratorio. Si estrinseca con pause idiopatiche nella respirazione, spesso associate alla riduzione della frequenza cardiaca e dei livelli di ossigeno nel sangue arterioso. Può essere aggravata da altre malattie concomitanti."},"nl":{"name":"Apneu door prematuriteit","definition":"Een ontwikkelingsstoornis die premature zuigelingen treft, waarschijnlijk secundair aan onvoldoende respiratoire controle die leidt tot idiopathische pauzes in de ademhaling, vaak geassocieerd met verminderde hartslag en zuurstofgehaltes in arterieel bloed. Het kan verergeren door gelijktijdige neonatale ziekten."},"pt":{"name":"Apneia da prematuridade (AOP)"},"pl":{"name":"Bezdech wcześniaków"},"cs":{"name":"Apnoe předčasně narozených"},"uk":{"name":"Апное недоношених","definition":"A developmental disorder affecting premature infants, likely secondary to an immaturity of respiratory control resulting in idiopathic pauses in breathing often associated with reduced heart rate and arterial blood oxygen levels. It may be exacerbated by concurrent neonatal diseases."},"zh":{"name":"早产儿呼吸暂停","definition":"一种影响早产儿的发育障碍，可能继发于呼吸控制不成熟导致的特发性呼吸暂停，通常与心率和动脉血氧水平降低有关。并发的新生儿疾病可能会加剧这种情况。"},"tr":{"name":"Prematüre apnesi"}},"xrefs":[{"source":"ICD-10","code":"P28.4","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"7A40.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"894774581"},{"source":"MONDO","code":"0020567","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0475715","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Infancy","Neonatal"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":8.5,"area":"Europe","status":"Validated","source":"European Medicines Agency 2003[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-10-11","source":"35251853[PMID]_23720269[PMID]_28722998[PMID]","terms":[{"hpo":"HP:0002104","label":"Apnea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000961","label":"Cyanosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001531","label":"Failure to thrive in infancy","frequency":"Occasional (29-5%)","criteria":null}]}}