Invasive mole
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Invasive mole | |
| fr | Môle invasive | |
| de | Invasive Mole | |
| es | Mola invasiva | |
| it | Mola invasiva | |
| nl | Invasieve mola | |
| pt | Mola invasiva | |
| pl | Zaśniad inwazyjny | |
| cs | Invazivní mola | |
| uk | Інвазивна родимка | |
| zh | 侵袭性葡萄胎 | |
| tr | İnvazif mol |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D39.2 | NTBT | inclusion | validated |
| ICD-11 | 2F76 | NTBT | index | validated |
| MONDO | 0020549 | E | validated | |
| MONDO | 20549 | E | validated | |
| MeSH | D002820 | E | validated | |
| UMLS | C0008493 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:59305Gestational trophoblastic neoplasm
rare neoplastic diseases; rare gynecological and obstetric diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
2 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0011433 | High maternal serum chorionic gonadotropin | |
| HP:0400008 | Menometrorrhagia | |
Run the differential on the 2 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/99925
- This record as JSON: /data/d/99925.json