{"orpha":99925,"name":"Invasive mole","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99925/","orphanet_url":"https://www.orpha.net/en/disease/detail/99925","names":{"fr":{"name":"Môle invasive","definition":"Forme de tumeur trophoblastique gestationnelle similaire à une môle hydatiforme avec une infiltration tumorale profonde du myomètre, caractérisée sur le plan histologique, par une hyperplasie des trophoblastes, une dégénérescence kystique généralisée des villosités choriales et par la présence de villosités molaires dans le myomètre et/ou dans les vaisseaux sanguins utérins. Les signes révélateurs sont une métrorragie persistante et inexpliquée ou une ré-ascension, une stagnation ou une absence de normalisation à six mois des taux de gonadotrophine chorionique totale (hCG) après évacuation d'une môle hydatiforme. Des métastases (pulmonaires ou vaginales) peuvent être observées."},"de":{"name":"Invasive Mole","definition":"Eine Form der trophoblastischen Neoplasie im Rahmen der Schwangerschaft, die einer hydatidiformen Mole ähnelt, jedoch eine tiefe Invasion in das Myometrium und eine histologisch charakterisierte Hyperplasie der Trophoblasten, eine generalisierte zystische Degeneration der Chorionzotten und das Vorhandensein von Molarzotten im Myometrium und/oder in den uterinen Blutgefäßen aufweist. Zu den indikativen Anzeichen gehören eine anhaltende, ungeklärte Metrorrhagie oder ein sekundärer Anstieg, eine Stagnation oder eine Nichtnormalisierung des Gesamtserumspiegels an Choriongonadotropin (hCG) innerhalb von 6 Monaten nach der Entfernung einer hydatidiformen Mole. Es können Metastasen (in der Lunge oder der Vagina) beobachtet werden."},"es":{"name":"Mola invasiva","definition":"Es una forma de neoplasia trofoblástica gestacional similar a la mola hidatiforme pero con invasión profunda del miometrio caracterizada histológicamente por hiperplasia trofoblástica, degeneración quística generalizada de las vellosidades coriónicas y presencia de vellosidades molares en el miometrio y/o los vasos sanguíneos uterinos. Los signos indicativos son la metrorragia persistente e inexplicable o el incremento secundario, el estancamiento o la no normalización a los 6 meses de los niveles totales de gonadotropina coriónica (hCG) en suero tras la evacuación uterina de una mola hidatiforme. Pueden observarse metástasis (en los pulmones o en la vagina)."},"it":{"name":"Mola invasiva"},"nl":{"name":"Invasieve mola","definition":"Een vorm van gestationele trofoblastische neoplasie gelijkaardig aan een mola-zwangerschap maar met diepe invasie in myometrium, en histologisch gekenmerkt door hyperplasie van trofoblasten, gegeneraliseerde cystische degeneratie van chorionvilli en aanwezigheid van molaire villi in myometrium en/or uteriene bloedvaten. Indicatieve verschijnselen zijn onder meer aanhoudende onverklaarbare metrorragie (onregelmatige intermenstruele bloeding) of secundaire toename, stagnatie of niet-normalisatie van totale gehaltes van choriongonadotrofine (hCG) in serum zes maanden na verwijdering van mola hydatidosa. Uitzaaiingen (in long of vagina) kunnen mogelijk waargenomen worden."},"pt":{"name":"Mola invasiva","definition":"Forma de neoplasia trofoblástica gestacional semelhante a uma mola hidatiforme, mas com invasão profunda no miométrio e hiperplasia de trofoblastos caracterizada histologicamente, degeneração quística generalizada das vilosidades coriónicas e presença de vilosidades molares no miométrio e/ou vasos sanguíneos uterinos. Os sinais incluem metrorragia persistente e inexplicável ou agravamento secundário, estabilização ou não normalização aos 6 meses dos níveis séricos totais de gonadotrofina coriónica (hCG) após a exclusão de uma mola hidatiforme. Podem ser observadas metástases (nos pulmões ou na vagina)."},"pl":{"name":"Zaśniad inwazyjny","definition":"Postać ciążowej choroby trofoblastycznej podobnej do zaśniadu groniastego, z głębokim naciekaniem mięśniówki macicy, histologicznie charakteryzującej się rozrostem komórek trofoblastu, uogólnionym zwyrodnieniem torbielowatym kosmków kosmówki i obecnością zaśniadowych kosmków w myometrium i/lub naczyniach krwionośnych macicy. Objawy wskaźnikowe dla choroby to niewyjaśnione krwotoki maciczne lub wtórny wzrost, stagnacja lub brak normalizacji po 6 miesiącach stężenia gonadotropiny kosmówkowej (hCG) w surowicy po usunięciu zaśniadu groniastego. Mogą wystąpić (do płuc lub pochwy)."},"cs":{"name":"Invazivní mola"},"uk":{"name":"Інвазивна родимка","definition":"A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometrium and histologically characterized by hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed."},"zh":{"name":"侵袭性葡萄胎","definition":"侵袭性葡萄胎是一种妊娠滋养细胞肿瘤(GTT；见该词条)，来源于葡萄胎(见该词条)延伸至子宫肌层。"},"tr":{"name":"İnvazif mol"}},"xrefs":[{"source":"ICD-10","code":"D39.2","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"2F76","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"8044628"},{"source":"MONDO","code":"0020549","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"20549","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002820","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0008493","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":59305,"name":"Gestational trophoblastic neoplasm","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0011433","label":"High maternal serum chorionic gonadotropin","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0400008","label":"Menometrorrhagia","frequency":"Very frequent (99-80%)","criteria":null}]}}