ORPHA:99867

Thymoma

Thymoma is a thymic epithelial neoplasm (TEN), a rare malignancy that arises from the epithelium of the thymic gland.

Names in Orphadata languages

12 of 12 languages

Lang	Name	Synonyms
en	Thymoma
fr	Thymome
de	Thymom
es	Timoma
it	Timoma	Neoplasia epiteliale primitiva del timo · Tumore epiteliale primitivo del timo
nl	Thymoom
pt	Timoma
pl	Grasiczak	Pierwotny guz nabłonka grasicy · Pierwotny nowotwór nabłonka grasicy
cs	Thymom	Primární thymická epiteliální neoplázie · Primární thymický epiteliální nádor
uk	Тимома	Первинне епітеліальне новоутворення тимуса · Первинна епітеліальна пухлина тимуса
zh	胸腺瘤	原发性胸腺上皮性肿瘤
tr	Timoma	Primer timik epitel tümörü · Primer timik epitel neoplazmı

Definition in:

qualifier = Orphanet mapping relation

Source	Code	Qualifier	ICD relation	Validation
OMIM	274230	BTNT		validated
ICD-10	D15.0	NTBT	attributed	validated
ICD-10	D38.4	BTNT	specific	validated
ICD-11	2C27.Y	NTBT	index	validated
MONDO	0006456	E		validated
MeSH	D013945	E		validated
UMLS	C0040100	E		validated
MedDRA	10043670	E		validated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

Children (3):

0 direct

Orphanet records no gene directly on this code.

3 records

Type	Class	Value	Area	Qualification	Validation	Source
Annual incidence	1-9 / 1 000 000	0.14 / 100 000	Europe	Value and class	Validated	[EXPERT]_RARECARE surveillance of rare cancers in Europe 2011[OTHER]
Lifetime Prevalence	1-9 / 100 000	1.22 / 100 000	Europe	Value and class	Validated	22033323[PMID]_[EXPERT]_RARECARE surveillance of rare cancers in Europe[OTHER]
Point prevalence	Unknown	—	Worldwide	Class only	Not yet validated	ORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

37 annotations · validated 2021-10-15

HPO	Term (as annotated by Orphanet)	Diagnostic
Frequent (79-30%)
HP:0031409	Abnormal lymphocyte physiology
HP:0031378	Abnormal lymphocyte proliferation
HP:0100749	Chest pain
HP:0001824	Weight loss
Occasional (29-5%)
HP:0045026	Abnormal mediastinum morphology
HP:0030208	Acetylcholine receptor antibody positivity
HP:0002960	Autoimmunity
HP:0012735	Cough
HP:0004313	Decreased circulating antibody level
HP:0002094	Dyspnea
HP:0001945	Fever
HP:0001609	Hoarse voice
HP:0002721	Immunodeficiency
HP:0001324	Muscle weakness
HP:0002664	Neoplasm
HP:0030166	Night sweats
Very rare (<4-1%)
HP:0000707	Abnormality of the nervous system
HP:0001915	Aplastic anemia
HP:0007108	Demyelinating peripheral neuropathy
HP:0000099	Glomerulonephritis
HP:0005560	Imbalanced hemoglobin synthesis
HP:0001909	Leukemia
HP:0003326	Myalgia
HP:0100614	Myositis
HP:0100527	Neoplasia of the pleura
HP:0012288	Neoplasm of head and neck
HP:0007378	Neoplasm of the gastrointestinal tract
HP:0100526	Neoplasm of the lung
HP:0100031	Neoplasm of the thyroid gland
HP:0012539	Non-Hodgkin lymphoma
HP:0031041	Obstruction of the superior vena cava
HP:0100787	Prostate neoplasm
HP:0012410	Pure red cell aplasia
HP:0001370	Rheumatoid arthritis
HP:0100324	Scleroderma
HP:0002725	Systemic lupus erythematosus
HP:0100279	Ulcerative colitis

Annotation source: 26818050[PMID]_28851660[PMID]