{"orpha":99867,"name":"Thymoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Thymoma is a thymic epithelial neoplasm (TEN), a rare malignancy that arises from the epithelium of the thymic gland.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99867/","orphanet_url":"https://www.orpha.net/en/disease/detail/99867","names":{"fr":{"name":"Thymome","definition":"Le thymome est une néoplasie épithéliale thymique , une tumeur rare dérivée de l'épithélium de la glande thymique."},"de":{"name":"Thymom","definition":"Das Thymom ist ein seltenes Neoplasma des Thymusepithels (TEN)."},"es":{"name":"Timoma","definition":"El timoma es una rara neoplasia epitelial de timo (TEN; ver término) que surge del epitelio tímico."},"it":{"name":"Timoma","synonyms":["Neoplasia epiteliale primitiva del timo","Tumore epiteliale primitivo del timo"]},"nl":{"name":"Thymoom","definition":"Thymoom is een epitheliaal neoplasma van de thymus (TEN; zie deze term), een zeldzame kwaadaardige aandoening die ontstaat uit het epitheel van de thymusklier."},"pt":{"name":"Timoma","definition":"O timoma é uma neoplasia epitelial tímica rara (TEN, ver este termo) que surge a partir do epitélio da glândula tímica."},"pl":{"name":"Grasiczak","synonyms":["Pierwotny guz nabłonka grasicy","Pierwotny nowotwór nabłonka grasicy"]},"cs":{"name":"Thymom","synonyms":["Primární thymická epiteliální neoplázie","Primární thymický epiteliální nádor"]},"uk":{"name":"Тимома","synonyms":["Первинне епітеліальне новоутворення тимуса","Первинна епітеліальна пухлина тимуса"],"definition":"Thymoma is a thymic epithelial neoplasm (TEN; see this term), a rare malignancy that arises from the epithelium of the thymic gland."},"zh":{"name":"胸腺瘤","synonyms":["原发性胸腺上皮性肿瘤"],"definition":"胸腺瘤是一种胸腺上皮肿瘤(10例，见该词条)，是一种罕见的恶性肿瘤，起源于胸腺上皮。"},"tr":{"name":"Timoma","synonyms":["Primer timik epitel tümörü","Primer timik epitel neoplazmı"]}},"xrefs":[{"source":"OMIM","code":"274230","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"D15.0","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"D38.4","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2C27.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"67403689"},{"source":"MONDO","code":"0006456","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D013945","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0040100","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10043670","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":3398,"name":"Thymic epithelial neoplasm","classifications":[202]}],"children":[{"orpha":263310,"name":"Thymoma type A","type":"Histopathological subtype"},{"orpha":263324,"name":"Thymoma type AB","type":"Histopathological subtype"},{"orpha":263317,"name":"Thymoma type B","type":"Histopathological subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.14,"area":"Europe","status":"Validated","source":"[EXPERT]_RARECARE surveillance of rare cancers in Europe 2011[OTHER]"},{"type":"Lifetime Prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.22,"area":"Europe","status":"Validated","source":"22033323[PMID]_[EXPERT]_RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-10-15","source":"26818050[PMID]_28851660[PMID]","terms":[{"hpo":"HP:0031409","label":"Abnormal lymphocyte physiology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031378","label":"Abnormal lymphocyte proliferation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0045026","label":"Abnormal mediastinum morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030208","label":"Acetylcholine receptor antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004313","label":"Decreased circulating antibody level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001609","label":"Hoarse voice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030166","label":"Night sweats","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001915","label":"Aplastic anemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007108","label":"Demyelinating peripheral neuropathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000099","label":"Glomerulonephritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005560","label":"Imbalanced hemoglobin synthesis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001909","label":"Leukemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100614","label":"Myositis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100527","label":"Neoplasia of the pleura","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012288","label":"Neoplasm of head and neck","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007378","label":"Neoplasm of the gastrointestinal tract","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100526","label":"Neoplasm of the lung","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100031","label":"Neoplasm of the thyroid gland","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012539","label":"Non-Hodgkin lymphoma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031041","label":"Obstruction of the superior vena cava","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100787","label":"Prostate neoplasm","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012410","label":"Pure red cell aplasia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001370","label":"Rheumatoid arthritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100324","label":"Scleroderma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002725","label":"Systemic lupus erythematosus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100279","label":"Ulcerative colitis","frequency":"Very rare (<4-1%)","criteria":null}]}}