raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:99745

Typhoid

Synonyms: Typhoid fever · Typhoidal salmonellosis

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

Typhoid or typhoid fever is a reportable, fecal-oral, potentially fatal infectious disease, caused by the bacteria <i>Salmonella typhi</i> and characterized by a non-focal fever.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enTyphoidTyphoid fever · Typhoidal salmonellosis
frTyphoïdeFièvre typhoïde
deTyphusEnterisches Fieber · Typhoide Salmonellose · Typhoides Fieber
esFiebre tifoideaSalmonelosis tifoidea
itTifoFebbre enterica · Febbre tifoide · Salmonellosi tifoide
nlTyfusBuiktyfus · Tyfeuze koorts · Tyfoïde salmonellose · Tyfuskoorts
ptTifóide
plDur brzusznyGorączka tyfusowa · Salmonelloza tyfusowa
csBřišní tyfusTyfová salmonelóza · Tyfová horečka
ukТифЧеревний тиф · Тифозний сальмонельоз
zh伤寒伤寒沙门氏菌病
trTifoTifo · Tifo salmonelloz

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A01.0Especificvalidated
ICD-111A07Especificvalidated
MONDO0005619Evalidated
MeSHD014435Evalidated
UMLSC0041466Evalidated
GARD9564Evalidated
MedDRA10045275Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

8 records
TypeClassValueAreaQualificationValidationSource
Annual incidence1-9 / 100 0003 / 100 000EuropeValue and classValidated15298225[PMID]_[EXPERT]_World Health Organization[OTHER]
Annual incidence>1 / 1000274 / 100 000South East AsiaValue and classValidated15298225[PMID]_World Health Organization[OTHER]
Annual incidence1-5 / 10 00053 / 100 000Latin AmericaValue and classValidated15298225[PMID]_World Health Organization[OTHER]
Annual incidence1-5 / 10 00050 / 100 000AfricaValue and classValidated15298225[PMID]_World Health Organization[OTHER]
Annual incidence1-9 / 1 000 000—North AmericaClass onlyValidated15298225[PMID]_World Health Organization[OTHER]
Annual incidence1-5 / 10 00015 / 100 000OceaniaValue and classValidated15298225[PMID]_World Health Organization[OTHER]
Annual incidence1-9 / 1 000 0000.2 / 100 000FranceValue and classValidatedOTHERitut Pasteur[OTHER]
Point prevalenceUnknown—WorldwideClass onlyNot yet validatedORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

27 annotations · validated 2016-06-01
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0002027Abdominal pain
HP:0012378Fatigue
HP:0001945Fever
HP:0002315Headache
HP:0100785Insomnia
Frequent (79-30%)
HP:0011675Arrhythmia
HP:0002829Arthralgia
HP:0001251Ataxia
HP:0002240Hepatomegaly
HP:0001347Hyperreflexia
HP:0001276Hypertonia
HP:0012733Macule
HP:0003326Myalgia
HP:0000988Skin rash
HP:0001744Splenomegaly
Occasional (29-5%)
HP:0006530Abnormal pulmonary interstitial morphology
HP:0001695Cardiac arrest
HP:0001259Coma
HP:0002019Constipation
HP:0012735Cough
HP:0002014Diarrhea
HP:0000421Epistaxis
HP:0002239Gastrointestinal hemorrhage
HP:0002383Infectious encephalitis
HP:0001254Lethargy
HP:0001337Tremor
HP:0004936Venous thrombosis

Run the differential on the 5 obligate / very frequent terms

7

Sources for this card