{"orpha":99745,"name":"Typhoid","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Typhoid fever","Typhoidal salmonellosis"],"definition":"Typhoid or typhoid fever is a reportable, fecal-oral, potentially fatal infectious disease, caused by the bacteria <i>Salmonella typhi</i> and characterized by a non-focal fever.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-99745/","orphanet_url":"https://www.orpha.net/en/disease/detail/99745","names":{"fr":{"name":"Typhoïde","synonyms":["Fièvre typhoïde"],"definition":"La typhoïde ou fièvre typhoïde est une maladie infectieuse oro-fécale potentiellement fatale à déclaration obligatoire causée par la bactérie <i>Salmonella typhi</i> et caractérisée par une fièvre non-focale."},"de":{"name":"Typhus","synonyms":["Enterisches Fieber","Typhoide Salmonellose","Typhoides Fieber"],"definition":"Typhus oder typhoides Fieber ist eine meldepflichtige, fäkal-orale, potenziell tödliche Infektionskrankheit, die durch das Bakterium Salmonella typhi verursacht wird und durch nicht-fokales Fieber gekennzeichnet ist."},"es":{"name":"Fiebre tifoidea","synonyms":["Salmonelosis tifoidea"],"definition":"La fiebre tifoidea es una enfermedad infecciosa de transmisión fecal-oral de declaración obligatoria y potencialmente letal causada por la bacteria <i>Salmonella Typhi</i> y que se caracteriza por fiebre no focal."},"it":{"name":"Tifo","synonyms":["Febbre enterica","Febbre tifoide","Salmonellosi tifoide"],"definition":"Il tifo o febbre tifoide è una malattia infettiva fecale-orale, potenzialmente letale, soggetta a possibile notifica, dovuta al batterio <i>Salmonella Typhi</i> e caratterizzata da febbre non focale."},"nl":{"name":"Tyfus","synonyms":["Buiktyfus","Tyfeuze koorts","Tyfoïde salmonellose","Tyfuskoorts"],"definition":"Tyfus of tyfeuze koorts is een rapporteerbare, fecaal-orale, potentieel fatale infectieziekte die veroorzaakt wordt door de bacterie <i>Salmonella typhi</i> en die gekenmerkt wordt door een niet-focale koorts."},"pt":{"name":"Tifóide"},"pl":{"name":"Dur brzuszny","synonyms":["Gorączka tyfusowa","Salmonelloza tyfusowa"]},"cs":{"name":"Břišní tyfus","synonyms":["Tyfová salmonelóza","Tyfová horečka"]},"uk":{"name":"Тиф","synonyms":["Черевний тиф","Тифозний сальмонельоз"],"definition":"Typhoid or typhoid fever is a reportable, fecal-oral, potentially fatal infectious disease, caused by the bacteria <i>Salmonella typhi</i> and characterized by a non-focal fever."},"zh":{"name":"伤寒","synonyms":["伤寒沙门氏菌病"],"definition":"伤寒是一种须上报的、具有潜在致命性的粪口传染病，由伤寒沙门氏菌 引起，以非局灶性发热为特征。"},"tr":{"name":"Tifo","synonyms":["Tifo","Tifo salmonelloz"]}},"xrefs":[{"source":"ICD-10","code":"A01.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1A07","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1528414070"},{"source":"MONDO","code":"0005619","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014435","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0041466","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9564","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10045275","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":795,"name":"Rare form of salmonellosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.0,"area":"Europe","status":"Validated","source":"15298225[PMID]_[EXPERT]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":">1 / 1000","value":274.0,"area":"South East Asia","status":"Validated","source":"15298225[PMID]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":53.0,"area":"Latin America","status":"Validated","source":"15298225[PMID]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":50.0,"area":"Africa","status":"Validated","source":"15298225[PMID]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Class only","class":"1-9 / 1 000 000","value":0.0,"area":"North America","status":"Validated","source":"15298225[PMID]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":15.0,"area":"Oceania","status":"Validated","source":"15298225[PMID]_World Health Organization[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"France","status":"Validated","source":"OTHERitut Pasteur[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100785","label":"Insomnia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001251","label":"Ataxia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002240","label":"Hepatomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001347","label":"Hyperreflexia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001276","label":"Hypertonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012733","label":"Macule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001744","label":"Splenomegaly","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006530","label":"Abnormal pulmonary interstitial morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001695","label":"Cardiac arrest","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000421","label":"Epistaxis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002239","label":"Gastrointestinal hemorrhage","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001254","label":"Lethargy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004936","label":"Venous thrombosis","frequency":"Occasional (29-5%)","criteria":null}]}}