Miller Fisher syndrome
Synonyms: Cranial variant of GBS · Cranial variant of Guillain-Barré syndrome · Fisher syndrome
- Type
- Disease
- Group
- Disorder
- Inheritance
- Multigenic/multifactorial, Not applicable
- Age of onset
- All ages
- Status
- active
A rare acquired peripheral neuropathy characterized by acute ophthalmoplegia, ataxia, and areflexia, typically manifesting with diplopia and unsteady gait, and generalized areflexia.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Miller Fisher syndrome | Cranial variant of GBS · Cranial variant of Guillain-Barré syndrome · Fisher syndrome |
| fr | Syndrome de Miller Fisher | Syndrome de Fisher · Variant crânien du SGB · Variant crânien du syndrome de Guillain-Barré |
| de | Miller-Fisher-Syndrom | Fisher-Syndrom · Guillain-Barré-Syndrom, kraniale Variante · Kraniale Variante des GBS |
| es | Síndrome de Miller-Fisher | Síndrome de Fisher · Variante craneal del SGB · Variante craneal del síndrome de Guillain-Barré |
| it | Sindrome di Miller-Fisher | Sindrome di Fisher · Sindrome di Guillain-Barré, variante cranica · Variante cranica di GBS |
| nl | Syndroom van Miller-Fisher | Craniale variant van GBS · Craniale variant van syndroom van Guillain-Barré · Syndroom van Fisher |
| pt | Síndrome Miller Fisher | |
| pl | Zespół Millera i Fishera | Wariant czaszkowy GBS · Wariant czaszkowy zespołu Guillaina i Barrégo · Zespół Fishera |
| cs | Miller-Fischerův syndrom | Kraniální varianta GBS · Kraniální varianta Guillainova-Barrého syndromu · Fisherův syndrom · Kraniální varianta Guillain-Barrého syndromu |
| uk | Синдром Міллера-Фішера | Краніальний варіант GBS · Краніальний варіант синдрому Гійєна-Барре · Синдром Фішера |
| zh | Miller Fisher综合征 | 吉兰巴雷综合征颅骨型 |
| tr | Miller Fisher sendromu | Fisher sendromu · GBS'nin kraniyal varyantı · Guillain-Barré sendromunun kraniyal varyantı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G61.0 | NTBT | attributed | validated |
| ICD-11 | 8C01.0 | NTBT | index | validated |
| MONDO | 0005851 | E | validated | |
| MeSH | D019846 | E | validated | |
| UMLS | C0393799 | E | validated | |
| GARD | 3668 | E | validated | |
| MedDRA | 10049567 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:231416Regional variant of Guillain-Barré syndrome
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 1 000 000 | 0.1 / 100 000 | Europe | Value and class | Validated | [EXPERT] |
| Point prevalence | 1-9 / 1 000 000 | — | Europe | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
26 annotations · validated 2023-03-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0034122 | Anti-GQ1b antibody positivity | |
| HP:0001284 | Areflexia | |
| HP:0000544 | External ophthalmoplegia | |
| Frequent (79-30%) | ||
| HP:0001251 | Ataxia | |
| HP:0000651 | Diplopia | |
| HP:0010845 | EEG with generalized slow activity | |
| HP:0003457 | EMG abnormality | |
| HP:0000666 | Horizontal nystagmus | |
| HP:0002922 | Increased CSF protein concentration | |
| HP:0007942 | Internal ophthalmoplegia | |
| HP:0011499 | Mydriasis | |
| Occasional (29-5%) | ||
| HP:0011347 | Abnormality of ocular abduction | |
| HP:0009916 | Anisocoria | |
| HP:0000622 | Blurred vision | |
| HP:0001283 | Bulbar palsy | |
| HP:0012229 | CSF pleocytosis | |
| HP:0010628 | Facial palsy | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0003401 | Paresthesia | |
| HP:0000613 | Photophobia | |
| HP:0004372 | Reduced consciousness | |
| HP:0002273 | Tetraparesis | |
| Very rare (<4-1%) | ||
| HP:0002015 | Dysphagia | |
| HP:0000508 | Ptosis | |
| HP:0002013 | Vomiting | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 33825117[PMID]_1532603[PMID]_11320188[PMID]_8030396[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/98919
- This record as JSON: /data/d/98919.json