Neuroleptic malignant syndrome
- Type
- Disease
- Group
- Disorder
- Inheritance
- Unknown
- Age of onset
- All ages
- Status
- active
A rare neuropsychiatric syndrome associated with administration of antipsychotic or other central dopamine (D2) receptor antagonists, and characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Neuroleptic malignant syndrome | |
| fr | Syndrome malin des neuroleptiques | |
| de | Malignes neuroleptisches Syndrom | |
| es | Síndrome neuroléptico maligno | |
| it | Sindrome neurolettica maligna | |
| nl | Neuroleptisch maligne syndroom | Maligne neurolepticasyndroom |
| pt | Síndrome de neuroleptico maligno | |
| pl | Złośliwy zespół neuroleptyczny | |
| cs | Maligní neuroleptický syndrom | |
| uk | Нейролептичний злоякісний синдром | |
| zh | 神经阻滞剂恶性综合征 | |
| tr | Nöroleptik habis sendrom |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G21.0 | E | specific | validated |
| ICD-11 | 8A0Y | NTBT | index | validated |
| MONDO | 0019790 | E | validated | |
| MeSH | D009459 | E | validated | |
| UMLS | C0027849 | E | validated | |
| GARD | 7195 | E | validated | |
| MedDRA | 10029282 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:466658Rare disease with malignant hyperthermia
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
54 annotations · validated 2019-02-25| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012332 | Abnormal autonomic nervous system physiology | |
| HP:0007076 | Extrapyramidal muscular rigidity | |
| HP:0001945 | Fever | |
| HP:0000975 | Hyperhidrosis | |
| HP:0002300 | Mutism | |
| HP:0004372 | Reduced consciousness | |
| Frequent (79-30%) | ||
| HP:0002307 | Drooling | |
| HP:0002015 | Dysphagia | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0003781 | Excessive salivation | |
| HP:0012378 | Fatigue | |
| HP:0000822 | Hypertension | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0001942 | Metabolic acidosis | |
| HP:0003394 | Muscle spasm | |
| HP:0001649 | Tachycardia | |
| HP:0001337 | Tremor | |
| Occasional (29-5%) | ||
| HP:0001919 | Acute kidney injury | |
| HP:0000713 | Agitation | |
| HP:0000739 | Anxiety | |
| HP:0011675 | Arrhythmia | |
| HP:0011951 | Aspiration pneumonia | |
| HP:0002072 | Chorea | |
| HP:0001259 | Coma | |
| HP:0001944 | Dehydration | |
| HP:0031258 | Delirium | |
| HP:0003155 | Elevated circulating alkaline phosphatase concentration | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0001298 | Encephalopathy | |
| HP:0002153 | Hyperkalemia | |
| HP:0003228 | Hypernatremia | |
| HP:0002905 | Hyperphosphatemia | |
| HP:0100735 | Hypertensive crisis | |
| HP:0002149 | Hyperuricemia | |
| HP:0002901 | Hypocalcemia | |
| HP:0002917 | Hypomagnesemia | |
| HP:0002902 | Hyponatremia | |
| HP:0002615 | Hypotension | |
| HP:0025435 | Increased circulating lactate dehydrogenase concentration | |
| HP:0002913 | Myoglobinuria | |
| HP:0040288 | Nasogastric tube feeding | |
| HP:0002018 | Nausea | |
| HP:0010553 | Oculogyric crisis | |
| HP:0000093 | Proteinuria | |
| HP:0002204 | Pulmonary embolism | |
| HP:0003201 | Rhabdomyolysis | |
| HP:0025145 | Rigors | |
| HP:0001894 | Thrombocytosis | |
| HP:0000020 | Urinary incontinence | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0001662 | Bradycardia | |
| HP:0002045 | Hypothermia | |
| HP:0100806 | Sepsis | |
| HP:0001873 | Thrombocytopenia | |
Run the differential on the 6 obligate / very frequent terms
Annotation source: 28144147[PMID]_29464217[PMID]_30765906[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/94093
- This record as JSON: /data/d/94093.json