{"orpha":94093,"name":"Neuroleptic malignant syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare neuropsychiatric syndrome associated with administration of antipsychotic or other central dopamine (D2) receptor antagonists, and characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-94093/","orphanet_url":"https://www.orpha.net/en/disease/detail/94093","names":{"fr":{"name":"Syndrome malin des neuroleptiques","definition":"Syndrome neuropsychiatrique rare associée à l'administration d'un antipsychotique ou d'autres antagonistes des récepteurs dopaminergiques (D2) à l'activité centrale, caractérisé par une hyperthermie, une rigidité musculaire, un dysfonctionnement autonome et une altération de la conscience."},"de":{"name":"Malignes neuroleptisches Syndrom","definition":"Ein seltenes neuropsychiatrisches Syndrom, das mit der Verabreichung von Antipsychotika oder anderen zentralen Dopamin(D2)-Rezeptor-Antagonisten einhergeht und durch Hyperthermie, Muskelsteifheit, autonome Funktionsstörungen und Bewusstseinsveränderungen gekennzeichnet ist."},"es":{"name":"Síndrome neuroléptico maligno","definition":"Es un síndrome neuropsiquiátrico poco frecuente asociado al consumo de antipsicóticos u otros antagonistas dopaminérgicos de acción central (D2), y caracterizado por hipertermia, rigidez muscular, disfunción autonómica y alteración de la conciencia."},"it":{"name":"Sindrome neurolettica maligna","definition":"La sindrome neurolettica maligna (NMS) è una malattia neuropsichiatrica rara associata all'assunzione di antipsicotici o altri antagonisti dei recettori della dopamina centrale (D2). È caratterizzata da ipertermia, rigidità muscolare, disfunzione del sistema autonomo ed alterazioni dello stato di coscienza."},"nl":{"name":"Neuroleptisch maligne syndroom","synonyms":["Maligne neurolepticasyndroom"],"definition":"Een zeldzaam neuropsychiatrisch syndroom geassocieerd met toediening van een antipsychoticum of andere antagonisten van centrale dopamine (D2)-receptor, en gekarakteriseerd door hyperthermie, musculaire rigiditeit, autonome disfunctie en gewijzigd bewustzijn."},"pt":{"name":"Síndrome de neuroleptico maligno"},"pl":{"name":"Złośliwy zespół neuroleptyczny"},"cs":{"name":"Maligní neuroleptický syndrom"},"uk":{"name":"Нейролептичний злоякісний синдром","definition":"A rare neuropsychiatric syndrome associated with administration of antipsychotic or other central dopamine (D2) receptor antagonists, and characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness."},"zh":{"name":"神经阻滞剂恶性综合征","definition":"一种罕见的神经精神综合征，与服用抗精神病药物或其他中枢多巴胺（D2）受体拮抗剂有关，其特征是体温过高、肌肉僵硬、自主神经功能障碍和意识改变。"},"tr":{"name":"Nöroleptik habis sendrom"}},"xrefs":[{"source":"ICD-10","code":"G21.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"8A0Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"498240876"},{"source":"MONDO","code":"0019790","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009459","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0027849","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7195","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10029282","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":466658,"name":"Rare disease with malignant hyperthermia","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Unknown"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-02-25","source":"28144147[PMID]_29464217[PMID]_30765906[PMID]","terms":[{"hpo":"HP:0012332","label":"Abnormal autonomic nervous system physiology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007076","label":"Extrapyramidal muscular rigidity","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002300","label":"Mutism","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002307","label":"Drooling","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003781","label":"Excessive salivation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001942","label":"Metabolic acidosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003394","label":"Muscle spasm","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000713","label":"Agitation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011951","label":"Aspiration pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002072","label":"Chorea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001944","label":"Dehydration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031258","label":"Delirium","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003155","label":"Elevated circulating alkaline phosphatase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002910","label":"Elevated circulating hepatic transaminase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001298","label":"Encephalopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002153","label":"Hyperkalemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003228","label":"Hypernatremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002905","label":"Hyperphosphatemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100735","label":"Hypertensive crisis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002149","label":"Hyperuricemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002901","label":"Hypocalcemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002917","label":"Hypomagnesemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002902","label":"Hyponatremia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002913","label":"Myoglobinuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040288","label":"Nasogastric tube feeding","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0010553","label":"Oculogyric crisis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000093","label":"Proteinuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002204","label":"Pulmonary embolism","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025145","label":"Rigors","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001894","label":"Thrombocytosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000020","label":"Urinary incontinence","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002045","label":"Hypothermia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Very rare (<4-1%)","criteria":null}]}}