Drug-induced localized lipodystrophy
Synonyms: Lipoatrophy caused by injected drug
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
Drug-induced localized lipodystrophy is a rare, acquired, localized lipodystrophy characterized by the appearance of asymptomatic, well-demarcated, variably sized, depressed, lipoatrophic lesions secondary to subcutaneous, intradermic or intramuscular drug injection, including corticosteroids, insulin, human growth hormone and antibiotics. Skin coloration may vary from white or hypopigmented to reddish, pinkish or violaceous. Epidermal atrophy may be also present.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Drug-induced localized lipodystrophy | Lipoatrophy caused by injected drug |
| fr | Lipodystrophie localisée médicamenteuse | |
| de | Arzneimittel-induzierte lokale Lipodystrophie | Lipoatrophie durch injizierte Medikamente |
| es | Lipodistrofia localizada inducida por fármacos | Lipoatrofia causada por fármacos inyectables |
| it | Lipodistrofia localizzata indotta da farmaci | |
| nl | Medicatiegeïnduceerde gelokaliseerde lipodystrofie | Lipoatrofie door geïnjecteerde medicatie |
| pt | Lipodistrofia localizada induzida por fármacos | |
| pl | Lipodystrofia zlokalizowana wywołana przez leki | = en |
| cs | Lokalizovaná lipodystrofie vyvolaná léky | = en |
| uk | Медикаментозна локалізована ліподистрофія | Ліпоатрофія, спричинена інєкційним наркотиком |
| zh | 药物诱导局限性脂肪代谢障碍 | 药物注射后脂肪萎缩 |
| tr | İlaca bağlı lokalize lipodistrofi | Enjekte edilen ilacın neden olduğu lipoatrofi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | E88.1 | NTBT | attributed | validated |
| ICD-11 | EF01.1 | NTBT | index | validated |
| MONDO | 0019553 | E | validated | |
| UMLS | C1274983 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:79088Localized lipodystrophy
rare skin diseases; rare endocrine diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 10 cases | Worldwide | Case(s) | Validated | 24336944[PMID]_17910713[PMID]_28979879[PMID] | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | 24336944[PMID]_17910713[PMID]_28979879[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
6 annotations · validated 2017-04-19| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0100578 | Lipoatrophy | |
| Very frequent (99-80%) | ||
| HP:0003758 | Reduced subcutaneous adipose tissue | |
| Frequent (79-30%) | ||
| HP:0007485 | Absence of subcutaneous fat | |
| Occasional (29-5%) | ||
| HP:0010783 | Erythema | |
| HP:0000953 | Hyperpigmentation of the skin | |
| HP:0001010 | Hypopigmentation of the skin | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 24336944[PMID]_8859277[PMID]_2974269[PMID]_1554737[PMID]_16638431[PMID]_24336944[PMID]_24961832[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/90157
- This record as JSON: /data/d/90157.json