{"orpha":90157,"name":"Drug-induced localized lipodystrophy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Lipoatrophy caused by injected drug"],"definition":"Drug-induced localized lipodystrophy is a rare, acquired, localized lipodystrophy characterized by the appearance of asymptomatic, well-demarcated, variably sized, depressed, lipoatrophic lesions secondary to subcutaneous, intradermic or intramuscular drug injection, including corticosteroids, insulin, human growth hormone and antibiotics. Skin coloration may vary from white or hypopigmented to reddish, pinkish or violaceous. Epidermal atrophy may be also present.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90157/","orphanet_url":"https://www.orpha.net/en/disease/detail/90157","names":{"fr":{"name":"Lipodystrophie localisée médicamenteuse","definition":"Une lipodystrophie localisée, acquise rare caractérisée par l'apparition de lésions lipoatrophiques déprimées, bien délimitées, de taille variable et asymptomatiques, secondairement à l'injection d'un médicament comme des corticostéroïdes, de l'insuline, de l'hormone de croissance humaine ou des antibiotiques par voie sous-cutanée, intradermique ou intramusculaire. La peau peut varier d'une coloration blanche ou hypopigmentée, à une coloration rougeâtre, rosâtre ou violacée. Une atrophie épidermique peut aussi être présente."},"de":{"name":"Arzneimittel-induzierte lokale Lipodystrophie","synonyms":["Lipoatrophie durch injizierte Medikamente"],"definition":"Die Arzneimittelinduzierte lokalisierte Lipodystrophie ist eine seltene, erworbene, lokalisierte Lipodystrophie, die durch das Auftreten von asymptomatischen, gut abgegrenzten, unterschiedlich großen, niedergedrückten, lipoatrophischen Läsionen sekundär zur subkutanen, intradermalen oder intramuskulären Injektion von Medikamenten, einschließlich Kortikosteroiden, Insulin, menschlichem Wachstumshormon und Antibiotika, gekennzeichnet ist. Die Hautfärbung kann von weiß oder hypopigmentiert bis rötlich, rosa oder violett variieren. Eine Atrophie der Epidermis kann ebenfalls vorhanden sein."},"es":{"name":"Lipodistrofia localizada inducida por fármacos","synonyms":["Lipoatrofia causada por fármacos inyectables"],"definition":"Es una lipodistrofia localizada, adquirida y poco frecuente, caracterizada por la aparición de lesiones lipoatróficas asintomáticas bien delimitadas, de tamaño variable y deprimidas, secundarias a la administración intradérmica o intramuscular de diversos fármacos, incluyendo corticosteroides, insulina, hormona del crecimiento y algunos antibioticos. El color de la piel puede variar de blanco o hipopigmentado a rojizo, rosado o violáceo. También puede asociarse a atrofia epidérmica."},"it":{"name":"Lipodistrofia localizzata indotta da farmaci","definition":"La lipodistrofia localizzata indotta da farmaci è una lipodistrofia acquisita, localizzata e rara, caratterizzata dalla presenza di lesioni lipoatrofiche depresse asintomatiche, ben delimitate, di dimensioni variabili, secondarie ad iniezioni sottocutanee, intradermiche o intramuscolari di farmaci (corticosteroidi, insulina, ormone della crescita umano e antibiotici). La cute può essere bianca o ipopigmentata, rossastra, rosata o violacea. Può associarsi ad atrofia dell'epidermide."},"nl":{"name":"Medicatiegeïnduceerde gelokaliseerde lipodystrofie","synonyms":["Lipoatrofie door geïnjecteerde medicatie"],"definition":"Geneesmiddel-geïnduceerde gelokaliseerde lipodystrofie is een zeldzame, verworven, gelokaliseerde lipodystrofie die gekarakteriseerd wordt door het verschijnen van asymptomatische, duidelijk begrensde, ingedrukte, lipoatrofische letsels met variabele omvang, secundair aan subcutane, intradermische of intramusculaire injectie van geneesmiddelen, waaronder corticosteroïden, insuline, humaan groeihormoon en antibiotica. Verkleuring van de huid kan variëren van wit of gehypopigmenteerd tot rood, roze of paars. Epidermale atrofie kan ook aanwezig zijn."},"pt":{"name":"Lipodistrofia localizada induzida por fármacos"},"pl":{"name":"Lipodystrofia zlokalizowana wywołana przez leki","synonyms":["Lipoatrophy caused by injected drug"],"definition":"*Lipodystrofia zlokalizowana wywołana przez leki jest rzadką, nabytą, zlokalizowaną lipodystrofią, charakteryzującą się pojawieniem się bezobjawowych, dobrze wyodrębnionych, o różnych rozmiarach, zagłębionych, lipoatroficznych zmian, wtórnych do podskórnego, śródskórnego lub domięśniowego wstrzyknięcia leku, w tym kortykosteroidów, insuliny, ludzkiego hormonu wzrostu i antybiotyków. Zabarwienie skóry może być zróżnicowane, od białego lub odbarwionego do czerwonawego, różowawego lub fiołkowego. Może jej towarzyszyć atrofia naskórka."},"cs":{"name":"Lokalizovaná lipodystrofie vyvolaná léky","synonyms":["Lipoatrophy caused by injected drug"]},"uk":{"name":"Медикаментозна локалізована ліподистрофія","synonyms":["Ліпоатрофія, спричинена інєкційним наркотиком"],"definition":"Drug-induced localized lipodystrophy is a rare, acquired, localized lipodystrophy characterized by the appearance of asymptomatic, well-demarcated, variably sized, depressed, lipoatrophic lesions secondary to subcutaneous, intradermic or intramuscular drug injection, including corticosteroids, insulin, human growth hormone and antibiotics. Skin coloration may vary from white or hypopigmented to reddish, pinkish or violaceous. Epidermal atrophy may be also present."},"zh":{"name":"药物诱导局限性脂肪代谢障碍","synonyms":["药物注射后脂肪萎缩"]},"tr":{"name":"İlaca bağlı lokalize lipodistrofi","synonyms":["Enjekte edilen ilacın neden olduğu lipoatrofi"]}},"xrefs":[{"source":"ICD-10","code":"E88.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"EF01.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1420628456"},{"source":"MONDO","code":"0019553","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1274983","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":79088,"name":"Localized lipodystrophy","classifications":[187,193]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":10.0,"area":"Worldwide","status":"Validated","source":"24336944[PMID]_17910713[PMID]_28979879[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"24336944[PMID]_17910713[PMID]_28979879[PMID]_ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-04-19","source":"24336944[PMID]_8859277[PMID]_2974269[PMID]_1554737[PMID]_16638431[PMID]_24336944[PMID]_24961832[PMID]","terms":[{"hpo":"HP:0100578","label":"Lipoatrophy","frequency":"Obligate (100%)","criteria":null},{"hpo":"HP:0003758","label":"Reduced subcutaneous adipose tissue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007485","label":"Absence of subcutaneous fat","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010783","label":"Erythema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000953","label":"Hyperpigmentation of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001010","label":"Hypopigmentation of the skin","frequency":"Occasional (29-5%)","criteria":null}]}}