Cocaine intoxication
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare disorder due to poisoning characterized by variable combination and dose-dependent severity of clinical manifestations, affecting behavior, central nervous and cardiovascular system. Patients present with euphoria, irritability, agitation, psychosis, hallucinations, paranoia, seizures, decreased responsiveness, mydriasis, tachyarrhythmia, chest pain, and cardiovascular collapse. Sometimes also dyspnea, hypertension, hyperthermia, hypothermia, lack of sleep and serotonin syndrome are present. Severe intoxication may lead to coma and death.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Cocaine intoxication | |
| fr | Intoxication à la cocaïne | |
| de | Kokain-Vergiftung | |
| es | Intoxicación por cocaína | |
| it | Intossicazione da cocaina | |
| nl | Cocaïne-intoxicatie | |
| pt | Envenenamento por cocaína | |
| pl | Zatrucie kokainą | |
| cs | Intoxikace kokainem | |
| uk | Кокаїнова інтоксикація | |
| zh | 可卡因中毒 | |
| tr | Kokain zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T40.5 | E | specific | validated |
| ICD-11 | 6C45.3 | E | specific | validated |
| MONDO | 0019544 | E | validated | |
| UMLS | C0009176 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 1 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2011[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
63 annotations · validated 2020-03-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0000713 | Agitation | |
| HP:0100749 | Chest pain | |
| HP:0001945 | Fever | |
| HP:0000975 | Hyperhidrosis | |
| HP:0000822 | Hypertension | |
| HP:0100754 | Mania | |
| HP:0011499 | Mydriasis | |
| HP:0011999 | Paranoia | |
| HP:0000709 | Psychosis | |
| HP:0000725 | Psychotic episodes | |
| HP:0001649 | Tachycardia | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0008765 | Auditory hallucinations | |
| HP:0012735 | Cough | |
| HP:0031258 | Delirium | |
| HP:0003236 | Elevated circulating creatine kinase concentration | |
| HP:0030157 | Flank pain | |
| HP:0025435 | Increased circulating lactate dehydrogenase concentration | |
| HP:0001658 | Myocardial infarction | |
| HP:0002018 | Nausea | |
| HP:0025421 | Pneumomediastinum | |
| HP:0002107 | Pneumothorax | |
| HP:0000093 | Proteinuria | |
| HP:0100598 | Pulmonary edema | |
| HP:0002113 | Pulmonary infiltrates | |
| HP:0004372 | Reduced consciousness | |
| HP:0005115 | Supraventricular arrhythmia | |
| HP:0002789 | Tachypnea | |
| HP:0006803 | Vivid hallucinations | |
| HP:0002013 | Vomiting | |
| HP:0030828 | Wheezing | |
| Very rare (<4-1%) | ||
| HP:0001919 | Acute kidney injury | |
| HP:0002647 | Aortic dissection | |
| HP:0002069 | Bilateral tonic-clonic seizure | |
| HP:0025085 | Bloody diarrhea | |
| HP:0001342 | Cerebral hemorrhage | |
| HP:0002583 | Colitis | |
| HP:0001259 | Coma | |
| HP:0000746 | Delusion | |
| HP:0025420 | Diffuse alveolar hemorrhage | |
| HP:0005521 | Disseminated intravascular coagulation | |
| HP:0007359 | Focal-onset seizure | |
| HP:0005244 | Gastrointestinal infarctions | |
| HP:0000099 | Glomerulonephritis | |
| HP:0000790 | Hematuria | |
| HP:0002105 | Hemoptysis | |
| HP:0002883 | Hyperventilation | |
| HP:0002615 | Hypotension | |
| HP:0011106 | Hypovolemia | |
| HP:0031368 | Intestinal perforation | |
| HP:0004305 | Involuntary movements | |
| HP:0002140 | Ischemic stroke | |
| HP:0011151 | Obtundation status | |
| HP:0006677 | Prolonged QRS complex | |
| HP:0001657 | Prolonged QT interval | |
| HP:0002098 | Respiratory distress | |
| HP:0003201 | Rhabdomyolysis | |
| HP:0001250 | Seizure | |
| HP:0002133 | Status epilepticus | |
| HP:0002138 | Subarachnoid hemorrhage | |
| HP:0001337 | Tremor | |
| HP:0001970 | Tubulointerstitial nephritis | |
| HP:0004308 | Ventricular arrhythmia | |
Annotation source: 22998988[PMID]_31679603[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/90068
- This record as JSON: /data/d/90068.json