{"orpha":90068,"name":"Cocaine intoxication","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare disorder due to poisoning characterized by variable combination and dose-dependent severity of clinical manifestations, affecting behavior, central nervous and cardiovascular system. Patients present with euphoria, irritability, agitation, psychosis, hallucinations, paranoia, seizures, decreased responsiveness, mydriasis, tachyarrhythmia, chest pain, and cardiovascular collapse. Sometimes also dyspnea, hypertension, hyperthermia, hypothermia, lack of sleep and serotonin syndrome are present. Severe intoxication may lead to coma and death.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-90068/","orphanet_url":"https://www.orpha.net/en/disease/detail/90068","names":{"fr":{"name":"Intoxication à la cocaïne","definition":"Maladie rare due à une intoxication caractérisée par l'association inconstante de manifestations cliniques, dont la sévérité dépend de la dose administrée, affectant le comportement, le système nerveux central et le système cardiovasculaire. Les patients présentent les signes et symptômes suivants : euphorie, irritabilité, agitation, psychose, hallucinations, paranoïa, convulsions, diminution de la réactivité, mydriase, tachyarythmie, douleurs thoraciques et collapsus cardiovasculaire. Dans de rares cas, une dyspnée, une hypertension, une hyperthermie, une hypothermie, un manque de sommeil et un syndrome sérotoninergique sont également rapportés. Une intoxication sévère peut entraîner un coma et le décès du patient."},"de":{"name":"Kokain-Vergiftung","definition":"Eine seltene Störung infolge einer Vergiftung, die das Verhalten, das zentrale Nervensystem und das Herz-Kreislauf-System beeinträchtigt und durch eine variable Kombination und dosisabhängige Schwere der klinischen Manifestationen gekennzeichnet ist. Die Patienten präsentieren sich mit Euphorie, Reizbarkeit, Unruhe, Psychose, Halluzinationen, Paranoia, Krampfanfällen, verminderter Reaktionsfähigkeit, Mydriasis, Tachyarrhythmie, Brustschmerzen und kardiovaskulärem Kollaps. Manchmal treten auch Dyspnoe, Hypertonie, Hyperthermie, Hypothermie, Schlafmangel und ein Serotonin-Syndrom auf. Schwere Vergiftungen können zu Koma und Tod führen."},"es":{"name":"Intoxicación por cocaína","definition":"Es un trastorno poco frecuente por intoxicación caracterizado por manifestaciones clínicas, de combinación variable y de gravedad dependiente de la dosis, que afectan a la conducta y al sistema nervioso central y cardiovascular. Los pacientes se presentan con euforia, irritabilidad, agitación, psicosis, alucinaciones, paranoia, crisis epilépticas, disminución de la capacidad de respuesta, midriasis, taquiarritmia, dolor torácico y colapso cardiovascular. En ocasiones también experimentan disnea, hipertensión, hipertermia, hipotermia, falta de sueño y síndrome de la serotonina. Una intoxicación grave puede conducir a coma y fallecimiento."},"it":{"name":"Intossicazione da cocaina","definition":"Si tratta di una malattia rara da intossicazione, caratterizzata dall'associazione tra diversi segni clinici, la cui gravità dipende dalla dose assunta, che interessano il comportamento, il sistema nervoso centrale e quello cardiovascolare. I pazienti presentano euforia, irritabilità, agitazione, psicosi, allucinazioni, paranoia, crisi epilettiche, scarsa risposta agli stimoli, midriasi, tachiaritmia, dolore toracico e collasso cardiovascolare. Talvolta i pazienti presentano anche dispnea, ipertensione, ipertermia, ipotermia, insonnia e sindrome da serotonina. Una grave intossicazione può esitare nel coma e nella morte."},"nl":{"name":"Cocaïne-intoxicatie","definition":"Een zeldzame stoornis als gevolg van vergiftiging, gekarakteriseerd door een variabele combinatie en dosis-afhankelijke ernst van klinische manifestaties, met aantasting van het gedrag, het centrale zenuwstelsel en het cardiovasculair systeem. Patiënten vertonen euforie, prikkelbaarheid, agitatie, psychose, hallucinaties, paranoia, insulten, verminderd reactievermogen, mydriasis, tachyaritmie, pijn in de borst, en cardiovasculaire collaps. Soms zijn ook dyspneu, hypertensie, hyperthermie, hypothermie, slaapgebrek en serotoninesyndroom aanwezig. Ernstige intoxicatie kan leiden tot coma en overlijden."},"pt":{"name":"Envenenamento por cocaína"},"pl":{"name":"Zatrucie kokainą"},"cs":{"name":"Intoxikace kokainem"},"uk":{"name":"Кокаїнова інтоксикація","definition":"A rare disorder due to poisoning characterized by variable combination and dose-dependent severity of clinical manifestations, affecting behavior, central nervous and cardiovascular system. Patients present with euphoria, irritability, agitation, psychosis, hallucinations, paranoia, seizures, decreased responsiveness, mydriasis, tachyarrhythmia, chest pain, and cardiovascular collapse. Sometimes also dyspnea, hypertension, hyperthermia, hypothermia, lack of sleep and serotonin syndrome are present. Severe intoxication may lead to coma and death."},"zh":{"name":"可卡因中毒"},"tr":{"name":"Kokain zehirlenmesi"}},"xrefs":[{"source":"ICD-10","code":"T40.5","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"6C45.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1965837313"},{"source":"MONDO","code":"0019544","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0009176","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2011[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-03-03","source":"22998988[PMID]_31679603[PMID]","terms":[{"hpo":"HP:0000713","label":"Agitation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000975","label":"Hyperhidrosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000822","label":"Hypertension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100754","label":"Mania","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011999","label":"Paranoia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000709","label":"Psychosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000725","label":"Psychotic episodes","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001649","label":"Tachycardia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008765","label":"Auditory hallucinations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031258","label":"Delirium","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003236","label":"Elevated circulating creatine kinase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030157","label":"Flank pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025435","label":"Increased circulating lactate dehydrogenase concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001658","label":"Myocardial infarction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025421","label":"Pneumomediastinum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000093","label":"Proteinuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100598","label":"Pulmonary edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002113","label":"Pulmonary infiltrates","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004372","label":"Reduced consciousness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005115","label":"Supraventricular arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002789","label":"Tachypnea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006803","label":"Vivid hallucinations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030828","label":"Wheezing","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001919","label":"Acute kidney injury","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002647","label":"Aortic dissection","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002069","label":"Bilateral tonic-clonic seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025085","label":"Bloody diarrhea","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001342","label":"Cerebral hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002583","label":"Colitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000746","label":"Delusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025420","label":"Diffuse alveolar hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005521","label":"Disseminated intravascular coagulation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007359","label":"Focal-onset seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0005244","label":"Gastrointestinal infarctions","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000099","label":"Glomerulonephritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000790","label":"Hematuria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002883","label":"Hyperventilation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011106","label":"Hypovolemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031368","label":"Intestinal perforation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004305","label":"Involuntary movements","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002140","label":"Ischemic stroke","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011151","label":"Obtundation status","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0006677","label":"Prolonged QRS complex","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001657","label":"Prolonged QT interval","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0003201","label":"Rhabdomyolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002133","label":"Status epilepticus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002138","label":"Subarachnoid hemorrhage","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001337","label":"Tremor","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001970","label":"Tubulointerstitial nephritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004308","label":"Ventricular arrhythmia","frequency":"Very rare (<4-1%)","criteria":null}]}}