raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:90037

Drug-induced autoimmune hemolytic anemia

Synonyms: Drug-induced AIHA

Type
Disease
Group
Disorder
Inheritance
Multigenic/multifactorial
Age of onset
All ages
Status
active

Drug-induced autoimmune hemolytic anemia is a type of autoimmune hemolytic anemia (AIHA) that occurs as a reaction to therapeutic drugs, and can be due to various mechanisms.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enDrug-induced autoimmune hemolytic anemiaDrug-induced AIHA
frAnémie hémolytique auto-immune induite par les médicamentsAIHA induite par les médicaments
deAnämie, autoimmun-hämolytische, Medikamenten-induzierte
esAnemia hemolítica autoinmune inducida por fármacosAHAI inducida por fármacos · AIHA inducida por fármacos · Anemia hemolítica autoinmune inducida por medicamentos
itAnemia emolitica autoimmune farmaco-indottaAIHA farmaco-indotta
nlMedicatiegeïnduceerde auto-immune hemolytische anemieMedicatiegeïnduceerde AIHA
ptAnemia hemolítica autoimune induzida por fármacos
plPolekowa niedokrwistość autoimmunohemolitycznaAIHA polekowa
csAutoimunitní hemolytická anémie vyvolaná lékyAIHA vyvolaná léky
ukМедикаментозна аутоімунна гемолітична анеміяМедикаментозна інтоксикація AIHA
zh药物性自身免疫性溶血性贫血药物诱导性AIHA
trİlaca bağlı otoimmün hemolitik anemiİlaçla indüklenen AIHA

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10D59.0NTBTattributedvalidated
ICD-113A20.YNTBTindexvalidated
MONDO0019535Evalidated
UMLSC0391817Evalidated
MedDRA10055213Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

1 record
TypeClassValueAreaQualificationValidationSource
Point prevalence<1 / 1 000 000—EuropeClass onlyNot yet validatedORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

11 annotations · validated 2016-06-01
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0001890Autoimmune hemolytic anemia
HP:0002875Exertional dyspnea
HP:0012378Fatigue
HP:0002315Headache
HP:0001324Muscle weakness
HP:0000980Pallor
Occasional (29-5%)
HP:0012086Abnormal urinary color
HP:0001635Congestive heart failure
HP:0003573Increased total bilirubin
HP:0001744Splenomegaly
HP:0001649Tachycardia

Run the differential on the 6 obligate / very frequent terms

7

Sources for this card