raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:74

Angiostrongyliasis

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

A foodborne zoonotic disease, endemic to Southeast Asia and the Pacific Islands, caused by the rat lungworm <i>Angiostrongylus cantonensis</i> and that is acquired by the ingestion of the infective larvae on vegetables or in raw or undercooked snails, slugs, land crabs, freshwater shrimps, frogs and lizards. The main feature is eosinophilic meningitis, with clinical manifestations including fever, headache, malaise, fatigue, vomiting, rhinorrhea, blurred vision, diplopia, cough, stiff neck, enteritis, constipation and paraesthesia due to the movement of the worms from the intestines to the lungs, central nervous system and eyes. In severe cases without treatment, coma and death can occur.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enAngiostrongyliasis
frAngiostrongylose
deAngiostrongyloseAngiostrongyliasis
esAngiostrongilosis
itAngiostrongilosi
nlAngiostrongyliasis
ptAngiostrongiliose
plAngiostrogyloza
csAngiostrongyliasis
ukАнгіостронгіліаз
zh血管圆线虫病
trAnjiyostrongiloz

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10B81.3BTNTspecificvalidated
ICD-10B83.2BTNTspecificvalidated
ICD-111F60Especificvalidated
ICD-111F60.0BTNTspecificvalidated
ICD-111F60.1BTNTspecificvalidated
ICD-111F60.YBTNTattributedvalidated
MONDO0019143Evalidated
MeSHC536369Evalidated
UMLSC0392662Evalidated
GARD683Evalidated
MedDRA10069517Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

1 record
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyNot yet validatedORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

39 annotations · validated 2020-04-14
HPOTerm (as annotated by Orphanet)Diagnostic
Very frequent (99-80%)
HP:0012229CSF pleocytosis
HP:0002315Headache
HP:0032061Hypereosinophilia
Frequent (79-30%)
HP:0002027Abdominal pain
HP:0002829Arthralgia
HP:0410263Brain imaging abnormality
HP:0002019Constipation
HP:0000651Diplopia
HP:0001262Excessive daytime somnolence
HP:0012378Fatigue
HP:0001945Fever
HP:0032064Gastrointestinal eosinophilia
HP:0002516Increased intracranial pressure
HP:0000737Irritability
HP:0001287Meningitis
HP:0003326Myalgia
HP:0003401Paresthesia
HP:0004396Poor appetite
HP:0002587Projectile vomiting
HP:0025258Stiff neck
HP:0011450Unusual CNS infection
HP:0002013Vomiting
Occasional (29-5%)
HP:0000622Blurred vision
HP:0002181Cerebral edema
HP:0002460Distal muscle weakness
HP:0003261Increased circulating IgA level
HP:0003237Increased circulating IgG level
HP:0003496Increased circulating IgM level
HP:0032336Increased circulating specific IgE antibody
HP:0001324Muscle weakness
HP:0002018Nausea
HP:0030833Neck pain
HP:0031179Nuchal rigidity
HP:0012531Pain
HP:0000989Pruritus
HP:0001250Seizure
HP:0002119Ventriculomegaly
Very rare (<4-1%)
HP:0001259Coma
HP:0100963Hyperesthesia

Run the differential on the 3 obligate / very frequent terms

Annotation source: 29411969[PMID]_18922484[PMID]_31287041[PMID]

7

Sources for this card