{"orpha":74,"name":"Angiostrongyliasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A foodborne zoonotic disease, endemic to Southeast Asia and the Pacific Islands, caused by the rat lungworm <i>Angiostrongylus cantonensis</i> and that is acquired by the ingestion of the infective larvae on vegetables or in raw or undercooked snails, slugs, land crabs, freshwater shrimps, frogs and lizards. The main feature is eosinophilic meningitis, with clinical manifestations including fever, headache, malaise, fatigue, vomiting, rhinorrhea, blurred vision, diplopia, cough, stiff neck, enteritis, constipation and paraesthesia due to the movement of the worms from the intestines to the lungs, central nervous system and eyes. In severe cases without treatment, coma and death can occur.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-74/","orphanet_url":"https://www.orpha.net/en/disease/detail/74","names":{"fr":{"name":"Angiostrongylose","definition":"Zoonose d'origine alimentaire, endémique en Asie du Sud-Est et dans les îles du Pacifique. Elle est provoquée par le ver pulmonaire du rat <i>Angiostrongylus cantonensis</i> et contractée par ingestion de larves infectieuses présentes sur des légumes ou sur des escargots, des limaces, des crabes terrestres, des crevettes d'eau douce, des grenouilles et des lézards crus ou mal cuits. Elle se manifeste principalement par une méningite à éosinophiles, et ses signes cliniques incluent fièvre, céphalée, malaise, fatigue, vomissements, rhinorrhée, vision trouble, diplopie, toux, raideur du cou, entérite, constipation ainsi que paresthésie entraînée par la migration des vers des intestins vers les poumons, le système nerveux central et les yeux. Dans les cas graves, en l'absence de traitement, un coma et le décès sont à craindre."},"de":{"name":"Angiostrongylose","synonyms":["Angiostrongyliasis"],"definition":"Eine in Südostasien und auf den pazifischen Inseln endemische, durch Lebensmittel übertragene Zoonose, die durch den Rattenlungenwurm <i>Angiostrongylus cantonensis</i> hervorgerufen wird und durch den Verzehr der infektiösen Larven auf Gemüse oder in rohen oder nicht ausreichend gekochten Schnecken, Schnecken, Landkrabben, Süßwassergarnelen, Fröschen und Eidechsen erworben wird. Das Hauptmerkmal ist eine eosinophile Meningitis mit klinischen Symptomen wie Fieber, Kopfschmerzen, Unwohlsein, Müdigkeit, Erbrechen, Rhinorrhoe, verschwommenes Sehen, Diplopie, Husten, steifer Nacken, Enteritis, Verstopfung und Parästhesien aufgrund der Wanderung der Würmer vom Darm in die Lunge, das zentrale Nervensystem und die Augen. In schweren Fällen kann es ohne Behandlung zu Koma und Tod kommen."},"es":{"name":"Angiostrongilosis","definition":"Es una enfermedad zoonótica de origen alimentario endémica del sudeste asiático y las islas del Pacífico, causada por un nematodo de roedores <i>Angiostrongylus cantonensis</i> (que suele encontrarse en las arterias pulmonares de rata, ''rat lungworm'') y que se adquiere por ingestión de la larva infectiva presente en verduras o en caracoles crudos o poco cocinados, babosas, cangrejos de tierra, gambas de agua dulce, ranas y lagartijas. La principal característica es la meningitis eosinofílica, con un cuadro clínico que incluye fiebre, cefalea, malestar, fatiga, vómitos, rinorrea, visión borrosa, diplopía, tos, rigidez en el cuello, enteritis, estreñimiento y parestesia, a causa del desplazamiento de los gusanos de los intestinos a los pulmones, al sistema nervioso central y los ojos. En casos graves sin tratamiento se puede producir coma y la muerte."},"it":{"name":"Angiostrongilosi","definition":"L'angiostrongilosi è una zoonosi di origine alimentare, endemica nel Sud-est asiatico e nelle isole del Pacifico, dovuta ad uno strongilide dei ratti, <i>Angiostrongylus cantonensis</i>, che si trasmette attraverso l'ingestione di larve infestanti presenti negli ortaggi o nelle lumache poco cotte o crude, nei limacidi, nei granchi di terra, nei gamberi d'acqua dolce, nelle rane e nelle lucertole. Il segno cardinale è la meningite eosinofila ed i segni clinici comprendono la febbre, la cefalea, il malessere, l'affaticamento, il vomito, la rinorrea, l'annebbiamento della vista, la diplopia, la tosse, il collo rigido, l'enterite, la costipazione e la parestesia, dovuti al passaggio dei vermi dall'intestino ai polmoni, al sistema nervoso centrale, agli occhi. Nei casi gravi non trattati, può sopraggiungere il coma e la morte."},"nl":{"name":"Angiostrongyliasis","definition":"Een via voedsel overgedragen, zoönotische ziekte, endemisch in Zuidoost-Azië en de Pacifische Eilanden, die veroorzaakt wordt door de longworm van de rat, <i>Angiostrongylus cantonensis</i>, en die wordt opgedaan door de inname van de infectieuze larven op groenten of in rauwe of niet voldoende gekookte huisjes- of naaktslakken, landkrabben, zoetwatergarnalen, kikkers en hagedissen. Het voornaamste kenmerk is eosinofiele meningitis, met klinische manifestaties als koorts, hoofdpijn, malaise, vermoeidheid, braken, rinorroe, troebel zicht, diplopie, hoest, stijve nek, enteritis, constipatie en paresthesie door de verplaatsing van wormen van de darmen naar de longen, het centrale zenuwstelsel en de ogen. In ernstige gevallen zonder behandeling kunnen coma en overlijden optreden."},"pt":{"name":"Angiostrongiliose"},"pl":{"name":"Angiostrogyloza"},"cs":{"name":"Angiostrongyliasis"},"uk":{"name":"Ангіостронгіліаз","definition":"A foodborne zoonotic disease, endemic to Southeast Asia and the Pacific Islands, caused by the rat lungworm <i>Angiostrongylus cantonensis</i> and that is acquired by the ingestion of the infective larvae on vegetables or in raw or undercooked snails, slugs, land crabs, freshwater shrimps, frogs and lizards. The main feature is eosinophilic meningitis, with clinical manifestations including fever, headache, malaise, fatigue, vomiting, rhinorrhea, blurred vision, diplopia, cough, stiff neck, enteritis, constipation and paraesthesia due to the movement of the worms from the intestines to the lungs, central nervous system and eyes. In severe cases without treatment, coma and death can occur."},"zh":{"name":"血管圆线虫病"},"tr":{"name":"Anjiyostrongiloz"}},"xrefs":[{"source":"ICD-10","code":"B81.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B83.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F60","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1768378720"},{"source":"ICD-11","code":"1F60.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1884500763"},{"source":"ICD-11","code":"1F60.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"53173615"},{"source":"ICD-11","code":"1F60.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0019143","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C536369","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0392662","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"683","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10069517","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-14","source":"29411969[PMID]_18922484[PMID]_31287041[PMID]","terms":[{"hpo":"HP:0012229","label":"CSF pleocytosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0032061","label":"Hypereosinophilia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0410263","label":"Brain imaging abnormality","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001262","label":"Excessive daytime somnolence","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032064","label":"Gastrointestinal eosinophilia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002516","label":"Increased intracranial pressure","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000737","label":"Irritability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004396","label":"Poor appetite","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002587","label":"Projectile vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002181","label":"Cerebral edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002460","label":"Distal muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003261","label":"Increased circulating IgA level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003237","label":"Increased circulating IgG level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032336","label":"Increased circulating specific IgE antibody","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002018","label":"Nausea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030833","label":"Neck pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031179","label":"Nuchal rigidity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012531","label":"Pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002119","label":"Ventriculomegaly","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001259","label":"Coma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100963","label":"Hyperesthesia","frequency":"Very rare (<4-1%)","criteria":null}]}}