Meconium aspiration syndrome
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Infancy, Neonatal
- Status
- active
Meconium aspiration syndrome is a pulmonary complication appearing in newborns with a meconium-stained amniotic fluid. Aspirated meconium can interfere with normal breathing by several mechanisms including airway obstruction, chemical irritation, infection and surfactant inactivation and induces more or less severe signs of respiratory distress at birth.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Meconium aspiration syndrome | |
| fr | Syndrome d'aspiration méconiale | |
| de | Mekonium-Aspirationssyndrom | |
| es | Síndrome de aspiración de meconio | |
| it | Sindrome da aspirazione di meconio | |
| nl | Meconiumaspiratiesyndroom | MAS |
| pt | Síndrome aspiração meconial | |
| pl | Zespół aspiracji smółki | |
| cs | Syndrom aspirace mekonia | |
| uk | Синдром аспірації меконієм | |
| zh | 胎粪吸入综合征 | |
| tr | Mekonyum aspirasyon sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P24.0 | E | specific | validated |
| ICD-11 | KB26.0 | E | specific | validated |
| MONDO | 0006851 | E | validated | |
| MeSH | D008471 | E | validated | |
| UMLS | C0025048 | E | validated | |
| GARD | 10494 | E | validated | |
| MedDRA | 10076496 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:101944Rare pulmonary disease
rare respiratory diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 2.44 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
22 annotations · validated 2020-02-12| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0031860 | Abnormal heart rate variability | |
| HP:0031983 | Abnormal pulmonary thoracic imaging finding | |
| HP:0011410 | Caesarian section | |
| HP:0025116 | Fetal distress | |
| HP:0031169 | Postterm pregnancy | |
| HP:0002098 | Respiratory distress | |
| HP:0005828 | Transient pulmonary infiltrates | |
| Occasional (29-5%) | ||
| HP:0011951 | Aspiration pneumonia | |
| HP:0100750 | Atelectasis | |
| HP:0012418 | Hypoxemia | |
| HP:0001511 | Intrauterine growth retardation | |
| HP:0009800 | Maternal diabetes | |
| HP:0008071 | Maternal hypertension | |
| HP:0012420 | Meconium stained amniotic fluid | |
| HP:0012768 | Neonatal asphyxia | |
| HP:0025421 | Pneumomediastinum | |
| HP:0002107 | Pneumothorax | |
| HP:0001788 | Premature rupture of membranes | |
| HP:0002092 | Pulmonary arterial hypertension | |
| HP:0030828 | Wheezing | |
| Very rare (<4-1%) | ||
| HP:0001298 | Encephalopathy | |
| HP:0010444 | Pulmonary insufficiency | |
Annotation source: 30058634[PMID]_31695993[PMID]_31295648[PMID]_31894896[PMID]_25274969[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/70588
- This record as JSON: /data/d/70588.json