{"orpha":70588,"name":"Meconium aspiration syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Meconium aspiration syndrome is a pulmonary complication appearing in newborns with a meconium-stained amniotic fluid. Aspirated meconium can interfere with normal breathing by several mechanisms including airway obstruction, chemical irritation, infection and surfactant inactivation and induces more or less severe signs of respiratory distress at birth.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-70588/","orphanet_url":"https://www.orpha.net/en/disease/detail/70588","names":{"fr":{"name":"Syndrome d'aspiration méconiale","definition":"Le syndrome d'aspiration méconiale est une complication pulmonaire survenant chez des nourrissons, nés en présence d'un liquide amniotique teinté de méconium. Le méconium aspiré peut empêcher une respiration normale par plusieurs mécanismes, dont l'obstruction des voies respiratoires, l'irritation chimique, l'infection et l'inactivation des surfactants. Elle induit des signes de détresse respiratoire plus ou moins sévère à la naissance."},"de":{"name":"Mekonium-Aspirationssyndrom","definition":"Das Mekonium-Aspirationssyndrom ist eine pulmonale Komplikation bei Neugeborenen mit mekoniumgefärbtem Fruchtwasser. Das aspirierte Mekonium beeinträchtigt die Atmung über mehrere Mechanismen (Verlegung der Atemwege, chemische Irritation, Infektion, Inaktivierung des Surfactants) und löst bei der Geburt mehr oder weniger schwere Symptome von Atemnot aus."},"es":{"name":"Síndrome de aspiración de meconio","definition":"El síndrome de aspiración de meconio es una complicación pulmonar que aparece en recién nacidos con líquido amniótico teñido de meconio. El meconio aspirado puede interferir con la respiración normal por diversos mecanismos incluyendo: obstrucción de las vías respiratorias, irritación química, infecciones e inactivación de los surfactantes; ocasiona signos más o menos graves de distrés respiratorio al nacer."},"it":{"name":"Sindrome da aspirazione di meconio","definition":"La sindrome da aspirazione di meconio è una complicazione polmonare che si manifesta nei neonati nel cui liquido amniotico è presente il meconio. Il meconio aspirato può interferire con la respirazione normale attraverso diversi meccanismi, come l'ostruzione delle vie aeree, l'irritazione chimica, l'infezione e l'inattivazione del surfattante, dando origine, alla nascita, a sintomi più o meno gravi di distress respiratorio."},"nl":{"name":"Meconiumaspiratiesyndroom","synonyms":["MAS"],"definition":"Een pulmonale complicatie die optreedt bij neonaten met meconiumhoudend vruchtwater. Geïnhaleerd meconium kan normale ademhaling verstoren via verschillende mechanismen, waaronder obstructie van luchtwegen, chemische irritatie, infectie, en inactivatie van surfactant, en induceert min of meer ernstige verschijnselen van ademnood bij de geboorte."},"pt":{"name":"Síndrome aspiração meconial"},"pl":{"name":"Zespół aspiracji smółki"},"cs":{"name":"Syndrom aspirace mekonia"},"uk":{"name":"Синдром аспірації меконієм","definition":"Meconium aspiration syndrome is a pulmonary complication appearing in newborns with a meconium-stained amniotic fluid. Aspirated meconium can interfere with normal breathing by several mechanisms including airway obstruction, chemical irritation, infection and surfactant inactivation and induces more or less severe signs of respiratory distress at birth."},"zh":{"name":"胎粪吸入综合征"},"tr":{"name":"Mekonyum aspirasyon sendromu"}},"xrefs":[{"source":"ICD-10","code":"P24.0","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"KB26.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"872221482"},{"source":"MONDO","code":"0006851","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008471","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0025048","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"10494","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10076496","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":101944,"name":"Rare pulmonary disease","classifications":[184]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Infancy","Neonatal"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":2.44,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-02-12","source":"30058634[PMID]_31695993[PMID]_31295648[PMID]_31894896[PMID]_25274969[PMID]","terms":[{"hpo":"HP:0031860","label":"Abnormal heart rate variability","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031983","label":"Abnormal pulmonary thoracic imaging finding","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011410","label":"Caesarian section","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025116","label":"Fetal distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031169","label":"Postterm pregnancy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005828","label":"Transient pulmonary infiltrates","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011951","label":"Aspiration pneumonia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100750","label":"Atelectasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001511","label":"Intrauterine growth retardation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009800","label":"Maternal diabetes","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008071","label":"Maternal hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012420","label":"Meconium stained amniotic fluid","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012768","label":"Neonatal asphyxia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025421","label":"Pneumomediastinum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002107","label":"Pneumothorax","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001788","label":"Premature rupture of membranes","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002092","label":"Pulmonary arterial hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030828","label":"Wheezing","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001298","label":"Encephalopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010444","label":"Pulmonary insufficiency","frequency":"Very rare (<4-1%)","criteria":null}]}}