Adult acute respiratory distress syndrome
Synonyms: Adult ARDS
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A very severe form of acute pulmonary failure secondary to capillary permeability impairment. The symptoms include dyspnea, hypotension and multivisceral failure. The disease is characterized by bilateral pulmonary infiltrates and severe hypoxemia due to increased alveolar-capillary permeability. The severity depends on the degree of alveolar epithelial injury, with a mortality rate of 30-50%.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Adult acute respiratory distress syndrome | Adult ARDS |
| fr | Syndrome de détresse respiratoire aiguë de l'adulte | Maladie des membranes hyalines de l'adulte |
| de | Akutes Atemnotsyndrom des Erwachsenen | ARDS des Erwachsenen · Atemnotsyndrom, adultes |
| es | Síndrome de dificultad respiratoria agudo del adulto | SDRA del adulto · Síndrome de distrés respiratorio agudo del adulto |
| it | Sindrome da distress respiratorio acuto dell'adulto | ARDS dell'adulto |
| nl | Acuut ademhalingsnoodsyndroom bij volwassenen | ARDS bij volwassenen · Acute respiratory distress-syndroom bij volwassenen |
| pt | Síndrome de dificuldade respiratória aguda do adulto | SDRA do adulto |
| pl | Zespół ostrej niewydolności oddechowej dorosłych | ARDS dorosłych |
| cs | Syndrom akutní respirační tísně u dospělých | Adultní ARDS |
| uk | Гострий респіраторний дистрес-синдром у дорослих | ARDS у дорослих |
| zh | 成人急性呼吸窘迫综合征 | 成人ARDS |
| tr | Yetişkin akut solunum sıkıntısı sendromu | Erişkin ARDS |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | J80 | E | specific | validated |
| ICD-11 | CB00 | NTBT | index | validated |
| MONDO | 0100130 | E | validated | |
| UMLS | C5680115 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:264740Primary interstitial lung disease specific to adulthood
rare respiratory diseases; rare transplant-related disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
8 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 6-9 / 10 000 | 64 / 100 000 | United States | Value and class | Validated | 16236739[PMID] |
| Point prevalence | 1-5 / 10 000 | 51 / 100 000 | United States | Value and class | Not yet validated | ORPHANET |
| Annual incidence | 1-5 / 10 000 | 11.5 / 100 000 | Iceland | Value and class | Not yet validated | 23216361[PMID]_10351930[PMID]_ ORPHANET |
| Annual incidence | 1-9 / 100 000 | 7.2 / 100 000 | Spain | Value and class | Validated | 21997128[PMID] |
| Annual incidence | 1-9 / 100 000 | 4.9 / 100 000 | Finland | Value and class | Validated | 10579250[PMID] |
| Annual incidence | 1-5 / 10 000 | 13.5 / 100 000 | Sweden | Value and class | Validated | 10351930[PMID] |
| Annual incidence | 1-5 / 10 000 | 13.5 / 100 000 | Denmark | Value and class | Validated | 10351930[PMID] |
| Point prevalence | 1-5 / 10 000 | — | Europe | Class only | Validated | European Medicines Agency 2008[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
17 annotations · validated 2019-06-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012415 | Abnormal blood gas level | |
| HP:0011117 | Abnormal circulating interleukin concentration | |
| HP:0002094 | Dyspnea | |
| HP:0012418 | Hypoxemia | |
| HP:0002113 | Pulmonary infiltrates | |
| Frequent (79-30%) | ||
| HP:0011118 | Abnormality of tumor necrosis factor secretion | |
| HP:0002615 | Hypotension | |
| HP:0030783 | Increased circulating interleukin 6 concentration | |
| HP:0001942 | Metabolic acidosis | |
| HP:0100598 | Pulmonary edema | |
| HP:0002878 | Respiratory failure | |
| HP:0100806 | Sepsis | |
| HP:0031273 | Shock | |
| Occasional (29-5%) | ||
| HP:0002090 | Pneumonia | |
| Very rare (<4-1%) | ||
| HP:0001953 | Diabetic ketoacidosis | |
| HP:0001733 | Pancreatitis | |
| HP:0002633 | Vasculitis | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 30078618[PMID]_29657094[PMID]_28406724[PMID]_30755248[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/70578
- This record as JSON: /data/d/70578.json