Post-selective serotonin reuptake inhibitor sexual dysfunction
Synonyms: PSSD · Post-SSRI sexual dysfunction
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Status
- active
A rare neurologic disease characterized by persistent side effects of depression treatment with selective serotonin reuptake inhibitors (SSRIs) manifests as a range of sexual and reproductive dysfunctions. Commonly experienced clinical signs in (male) patients include the triad of genital anesthesia, decreased or lost libido, and erectile dysfunction, as well as weak or pleasureless orgasm, premature ejaculation, reduced penile size, decreased seminal volume, and testicular atrophy or pain. In female patients, additional manifestations may include vaginal lubrication difficulties, irregular menstruation, and nipple insensitivity. These symptoms may begin days or weeks after initiation of treatment and can persist even after the medication is discontinued, significantly impacting quality of life.
Names in Orphadata languages
9 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Post-selective serotonin reuptake inhibitor sexual dysfunction | PSSD · Post-SSRI sexual dysfunction |
| fr | Dysfonction sexuelle après arrêt des inhibiteurs sélectifs de la recapture de la sérotonine | Dysfonction sexuelle post-ISRS · PSSD |
| de | SSRI-bedingte sexuelle Dysfunktion | PSSD · Post-SSRI-Sexualdysfunktion |
| es | Disfunción sexual post-inhibidor selectivo de la recaptación de serotonina | DSRS · Disfunción sexual post-ISRS · PSSD |
| it | Disfunzione sessuale post-inibitori selettivi della ricaptazione della serotonina | PSSD · Disfunzione sessuale post-SSRI |
| nl | Seksuele disfunctie na selectieve serotonineheropnameremmer | PSSD · Post-SSRI seksuele disfunctie |
| pt | Disfunção sexual pós-inibidor seletivo de recaptação de serotonina | Disfunção sexual pós-SSRI · PSSD |
| pl | Post-selective serotonin reuptake inhibitor sexual dysfunction | = en |
| cs | Sexuální dysfunkce po selektivním inhibitoru zpětného vychytávání serotoninu | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | F52.8 | NTBT | attributed | not yet validated |
| MONDO | 975898 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98006Rare neurologic disease
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/686475
- This record as JSON: /data/d/686475.json