{"orpha":686475,"name":"Post-selective serotonin reuptake inhibitor sexual dysfunction","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["PSSD","Post-SSRI sexual dysfunction"],"definition":"A rare neurologic disease characterized by persistent side effects of depression treatment with selective serotonin reuptake inhibitors (SSRIs) manifests as a range of sexual and reproductive dysfunctions. Commonly experienced clinical signs in (male) patients include the triad of genital anesthesia, decreased or lost libido, and erectile dysfunction, as well as weak or pleasureless orgasm, premature ejaculation, reduced penile size, decreased seminal volume, and testicular atrophy or pain. In female patients, additional manifestations may include vaginal lubrication difficulties, irregular menstruation, and nipple insensitivity. These symptoms may begin days or weeks after initiation of treatment and can persist even after the medication is discontinued, significantly impacting quality of life.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-686475/","orphanet_url":"https://www.orpha.net/en/disease/detail/686475","names":{"fr":{"name":"Dysfonction sexuelle après arrêt des inhibiteurs sélectifs de la recapture de la sérotonine","synonyms":["Dysfonction sexuelle post-ISRS","PSSD"],"definition":"Maladie neurologique rare, caractérisée par des effets secondaires persistants liés au traitement de la dépression par des inhibiteurs sélectifs de la recapture de la sérotonine (ISRS), se manifestant par toute une série de troubles sexuels et de la reproduction. Les signes cliniques fréquemment observés chez les patients (de sexe masculin) comprennent la triade associant anesthésie génitale, baisse ou perte de la libido et dysfonction érectile, ainsi qu'un orgasme faible ou sans plaisir, une éjaculation précoce, une diminution de la taille du pénis, une diminution du volume séminal et une atrophie ou des douleurs testiculaires. Chez les patientes, on observe d'autres signes, parmi lesquels des difficultés de lubrification vaginale, des règles irrégulières et une insensibilité des mamelons. Ces symptômes peuvent apparaître quelques jours ou quelques semaines après le début du traitement et persister même après l'arrêt du médicament, altérant ainsi considérablement la qualité de vie."},"de":{"name":"SSRI-bedingte sexuelle Dysfunktion","synonyms":["PSSD","Post-SSRI-Sexualdysfunktion"]},"es":{"name":"Disfunción sexual post-inhibidor selectivo de la recaptación de serotonina","synonyms":["DSRS","Disfunción sexual post-ISRS","PSSD"]},"it":{"name":"Disfunzione sessuale post-inibitori selettivi della ricaptazione della serotonina","synonyms":["PSSD","Disfunzione sessuale post-SSRI"]},"nl":{"name":"Seksuele disfunctie na selectieve serotonineheropnameremmer","synonyms":["PSSD","Post-SSRI seksuele disfunctie"]},"pt":{"name":"Disfunção sexual pós-inibidor seletivo de recaptação de serotonina","synonyms":["Disfunção sexual pós-SSRI","PSSD"]},"pl":{"name":"Post-selective serotonin reuptake inhibitor sexual dysfunction","synonyms":["PSSD","Post-SSRI sexual dysfunction"]},"cs":{"name":"Sexuální dysfunkce po selektivním inhibitoru zpětného vychytávání serotoninu","synonyms":["PSSD","Post-SSRI sexual dysfunction"]}},"xrefs":[{"source":"ICD-10","code":"F52.8","qualifier":"NTBT","icd_relation":"attributed","validated":false},{"source":"MONDO","code":"975898","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":98006,"name":"Rare neurologic disease","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":[],"prevalence":[],"phenotypes":null}